General Structure Information 1tki TTN autoinhibited serine kinase domain of the giant muscle protein titin 2.0Å AUTH O.MAYANS,P.F.VAN DER VEN,M.WILM,A.MUES,P.YOUNG,AUTH 2 D.O.FURST,M.WILMANNS,M.GAUTELTITL STRUCTURAL BASIS FOR ACTIVATION OF THE TITINTITL 2 KINASE DOMAIN DURING MYOFIBRILLOGENESIS.REF NATURE V. 395 863 1998REFN ISSN 0028-0836PMID 9804419DOI 10.1038/27603 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4fg8 CAMK1 crystal structure of human calcium/calmodulin-dependent protein kinase i 1-315 in complex with atp 2.2Å AUTH M.ZHA,C.ZHONG,Y.OU,L.HAN,J.WANG,J.DINGTITL CRYSTAL STRUCTURES OF HUMAN CAMKIALPHA REVEAL INSIGHTS INTOTITL 2 THE REGULATION MECHANISM OF CAMKI.REF PLOS ONE V. 7 44828 2012REFN ESSN 1932-6203PMID 23028635DOI 10.1371/JOURNAL.PONE.0044828 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3eto NOTCH1 2 angstrom xray structure of the notch1 negative regulatory region (nrr) 2.0Å AUTH W.R.GORDON,M.ROY,D.VARDAR-ULU,M.GARFINKEL,M.R.MANSOUR,AUTH 2 J.C.ASTER,S.C.BLACKLOWTITL STRUCTURE OF THE NOTCH1-NEGATIVE REGULATORY REGION:TITL 2 IMPLICATIONS FOR NORMAL ACTIVATION AND PATHOGENIC SIGNALINGTITL 3 IN T-ALL.REF BLOOD V. 113 4381 2009REFN ISSN 0006-4971PMID 19075186DOI 10.1182/BLOOD-2008-08-174748 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2ozo ZAP70 autoinhibited intact human zap-70 2.6Å AUTH S.DEINDL,T.A.KADLECEK,T.BRDICKA,X.CAO,A.WEISS,AUTH 2 J.KURIYANTITL STRUCTURAL BASIS FOR THE INHIBITION OF TYROSINETITL 2 KINASE ACTIVITY OF ZAP-70.REF CELL(CAMBRIDGE,MASS.) V. 129 735 2007REFN ISSN 0092-8674PMID 17512407DOI 10.1016/J.CELL.2007.03.039 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1rjb FLT3 crystal structure of flt3 2.1Å AUTH J.GRIFFITH,J.BLACK,C.FAERMAN,L.SWENSON,M.WYNN,F.LU,AUTH 2 J.LIPPKE,K.SAXENATITL THE STRUCTURAL BASIS FOR AUTOINHIBITION OF FLT3 BYTITL 2 THE JUXTAMEMBRANE DOMAIN.REF MOL.CELL V. 13 169 2004REFN ISSN 1097-2765PMID 14759363DOI 10.1016/S1097-2765(03)00505-7 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3e2u CLIP1 crystal structure of the zink-knuckle 2 domain of human clip-170 in complex with cap-gly domain of human dynactin-1 (p150-glued) 2.6Å AUTH A.WEISBRICH,S.HONNAPPA,R.JAUSSI,O.OKHRIMENKO,D.FREY,AUTH 2 I.JELESAROV,A.AKHMANOVA,M.O.STEINMETZTITL STRUCTURE-FUNCTION RELATIONSHIP OF CAP-GLY DOMAINSREF NAT.STRUCT.MOL.BIOL. V. 14 959 2007REFN ISSN 1545-9993PMID 17828277DOI 10.1038/NSMB1291 Variant Set Distributions Mapped Variants
General Structure Information 3ri4 ETS1 ets1 cooperative binding to widely separated sites on promoter dna 3.0Å AUTH N.D.BABAYEVA,O.I.BARANOVSKAYA,T.H.TAHIROVTITL STRUCTURAL BASIS OF ETS1 COOPERATIVE BINDING TO WIDELYTITL 2 SEPARATED SITES ON PROMOTER DNA.REF PLOS ONE V. 7 33698 2012REFN ESSN 1932-6203PMID 22432043DOI 10.1371/JOURNAL.PONE.0033698 Variant Set Distributions Mapped Variants
General Structure Information 2fo0 ABL1 organization of the sh3-sh2 unit in active and inactive forms of the c-abl tyrosine kinase 2.27Å AUTH B.NAGAR,O.HANTSCHEL,M.SEELIGER,J.M.DAVIES,W.I.WEIS,AUTH 2 G.SUPERTI-FURGA,J.KURIYANTITL ORGANIZATION OF THE SH3-SH2 UNIT IN ACTIVE AND INACTIVETITL 2 FORMS OF THE C-ABL TYROSINE KINASE.REF MOL.CELL V. 21 787 2006REFN ISSN 1097-2765PMID 16543148DOI 10.1016/J.MOLCEL.2006.01.035 Variant Set Distributions Ripley’s K […]