General Structure Information 3sog AMPH crystal structure of the bar domain of human amphiphysin, isoform 1 2.3Å Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3fey KPNA2 crystal structure of the cbc-importin alpha complex. 2.2Å AUTH S.M.DIAS,K.F.WILSON,K.S.ROJAS,A.L.AMBROSIO,R.A.CERIONETITL THE MOLECULAR BASIS FOR THE REGULATION OF THE CAP-BINDINGTITL 2 COMPLEX BY THE IMPORTINS.REF NAT.STRUCT.MOL.BIOL. V. 16 930 2009REFN ISSN 1545-9993PMID 19668212DOI 10.1038/NSMB.1649 Variant Set Distributions Mapped Variants
General Structure Information 3jwq PDE6C crystal structure of chimeric pde5/pde6 catalytic domain complexed with sildenafil 2.87Å AUTH B.BARREN,L.GAKHAR,H.MURADOV,K.K.BOYD,S.RAMASWAMY,AUTH 2 N.O.ARTEMYEVTITL STRUCTURAL BASIS OF PHOSPHODIESTERASE 6 INHIBITION BY THETITL 2 C-TERMINAL REGION OF THE GAMMA-SUBUNITREF EMBO J. V. 28 3613 2009REFN ISSN 0261-4189PMID 19798052DOI 10.1038/EMBOJ.2009.284 Variant Set Distributions Mapped Variants
General Structure Information 2dat SMARCA2 solution structure of the bromodomain of human swi/snf related matrix associated actin dependent regulator of cromatin subfamily a member 2 -1.0Å AUTH M.YONEYAMA,T.KIGAWA,K.SAITO,N.TOCHIO,S.KOSHIBA,AUTH 2 M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE BROMODOMAIN OF HUMANTITL 2 SWI/SNF RELATED MATRIX ASSOCIATED ACTIN DEPENDENTTITL 3 REGULATOR OF CROMATIN SUBFAMILY A MEMBER 2REF TO BE PUBLISHEDREFN […]
General Structure Information 3fay IQGAP1 crystal structure of the gap-related domain of iqgap1 2.2Å AUTH V.B.KURELLA,J.M.RICHARD,C.L.PARKE,L.F.LECOUR,AUTH 2 H.D.BELLAMY,D.K.WORTHYLAKETITL CRYSTAL STRUCTURE OF THE GTPASE-ACTIVATINGTITL 2 PROTEIN-RELATED DOMAIN FROM IQGAP1.REF J.BIOL.CHEM. V. 284 14857 2009REFN ISSN 0021-9258PMID 19321438DOI 10.1074/JBC.M808974200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2rnr GTF2H1 solution structure of the complex between tfiie alpha c- terminal acidic domain and tfiih p62 ph domain -1.0Å AUTH M.OKUDA,A.TANAKA,M.SATOH,S.MIZUTA,M.TAKAZAWA,AUTH 2 Y.OHKUMA,Y.NISHIMURATITL STRUCTURAL INSIGHT INTO THE TFIIE-TFIIHTITL 2 INTERACTION: TFIIE AND P53 SHARE THE BINDINGTITL 3 REGION ON TFIIHREF EMBO J. V. 27 1161 2008REFN ISSN 0261-4189PMID 18354501DOI 10.1038/EMBOJ.2008.47 Variant […]
General Structure Information 1ej5 WAS solution structure of the autoinhibited conformation of wasp -1.0Å AUTH A.S.KIM,L.T.KAKALIS,N.ABDUL-MANAN,G.A.LIU,M.K.ROSENTITL AUTOINHIBITION AND ACTIVATION MECHANISMS OF THETITL 2 WISKOTT-ALDRICH SYNDROME PROTEIN.REF NATURE V. 404 151 2000REFN ISSN 0028-0836PMID 10724160DOI 10.1038/35010088 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1n83 RORA crystal structure of the complex between the orphan nuclear hormone receptor ror(alpha)-lbd and cholesterol 1.63Å AUTH J.A.KALLEN,J.M.SCHLAEPPI,F.BITSCH,S.GEISSE,AUTH 2 M.GEISER,I.DELHON,B.FOURNIERTITL X-RAY STRUCTURE OF HROR(ALPHA) LBD AT 1.63A:TITL 2 STRUCTURAL AND FUNCTIONAL DATA THAT CHOLESTEROL ORTITL 3 A CHOLESTEROL DERIVATIVE IS THE NATURAL LIGAND OFTITL 4 ROR(ALPHA)REF STRUCTURE V. 10 1697 2002REFN […]
General Structure Information 2l27 CRHR1 nmr structure of the ecd1 of crf-r1 in complex with a peptide agonist -1.0Å AUTH C.R.GRACE,M.H.PERRIN,J.GULYAS,J.E.RIVIER,W.W.VALE,R.RIEKTITL NMR STRUCTURE OF THE FIRST EXTRACELLULAR DOMAIN OFTITL 2 CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1 (ECD1-CRF-R1)TITL 3 COMPLEXED WITH A HIGH AFFINITY AGONIST.REF J.BIOL.CHEM. V. 285 38580 2010REFN ISSN 0021-9258PMID 20843795DOI 10.1074/JBC.M110.121897 Variant Set Distributions Mapped […]
General Structure Information 4mxw LTBR structure of heterotrimeric lymphotoxin lta1b2 bound to lymphotoxin beta receptor ltbr and anti-lta fab 3.6Å AUTH J.SUDHAMSU,J.YIN,E.Y.CHIANG,M.A.STAROVASNIK,J.L.GROGAN,AUTH 2 S.G.HYMOWITZTITL DIMERIZATION OF LT BETA R BY LT ALPHA 1 BETA 2 IS NECESSARYTITL 2 AND SUFFICIENT FOR SIGNAL TRANSDUCTION.REF PROC.NATL.ACAD.SCI.USA V. 110 19896 2013REFN ISSN 0027-8424PMID 24248355DOI 10.1073/PNAS.1310838110 Variant Set Distributions […]