Assessment of Structural Intolerance and Durability
General Structure Information 2ee5 ARHGAP5 solution structure of the n-teruminus extended rhogap domain from human rho gtpase activating protein 5 variant -1.0Å AUTH T.TOMIZAWA,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERUMINUS EXTENDEDTITL 2 RHOGAP DOMAIN FROM HUMAN RHO GTPASE ACTIVATINGTITL 3 PROTEIN 5 VARIANTREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1z68 FAP crystal structure of human fibroblast activation protein alpha 2.6Å AUTH K.AERTGEERTS,I.LEVIN,L.SHI,G.P.SNELL,A.JENNINGS,G.S.PRASAD,AUTH 2 Y.ZHANG,M.L.KRAUS,S.SALAKIAN,V.SRIDHAR,R.WIJNANDS,AUTH 3 M.G.TENNANTTITL STRUCTURAL AND KINETIC ANALYSIS OF THE SUBSTRATE SPECIFICITYTITL 2 OF HUMAN FIBROBLAST ACTIVATION PROTEIN ALPHA.REF J.BIOL.CHEM. V. 280 19441 2005REFN ISSN 0021-9258PMID 15809306DOI 10.1074/JBC.C500092200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2jjs CD47 structure of human cd47 in complex with human signal regulatory protein (sirp) alpha 1.85Å AUTH D.HATHERLEY,S.C.GRAHAM,J.TURNER,K.HARLOS,AUTH 2 D.I.STUART,A.N.BARCLAYTITL PAIRED RECEPTOR SPECIFICITY EXPLAINED BYTITL 2 STRUCTURES OF SIGNAL REGULATORY PROTEINS ALONE ANDTITL 3 COMPLEXED WITH CD47.REF MOL.CELL V. 31 266 2008REFN ISSN 1097-2765PMID 18657508DOI 10.1016/J.MOLCEL.2008.05.026 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3sh5 HSPG2 calcium-bound laminin g like domain 3 from human perlecan 2.8Å AUTH B.VAN LE,H.KIM,J.CHOI,J.H.KIM,M.J.HAHN,C.LEE,K.K.KIM,AUTH 2 H.Y.HWANGTITL CRYSTAL STRUCTURE OF THE LG3 DOMAIN OF ENDOREPELLIN, ANTITL 2 ANGIOGENESIS INHIBITOR.REF J.MOL.BIOL. V. 414 231 2011REFN ISSN 0022-2836PMID 21996443DOI 10.1016/J.JMB.2011.09.048 Variant Set Distributions Mapped Variants
General Structure Information 2o94 HDAC4 the 97h/f mutant structure of a glutamine-rich domain from histone deacetylase 4 3.0Å AUTH L.GUO,A.HAN,D.L.BATES,J.CAO,L.CHENTITL CRYSTAL STRUCTURE OF A CONSERVED N-TERMINAL DOMAINTITL 2 OF HISTONE DEACETYLASE 4 REVEALS FUNCTIONALTITL 3 INSIGHTS INTO GLUTAMINE-RICH DOMAINS.REF PROC.NATL.ACAD.SCI.USA V. 104 4297 2007REFN ISSN 0027-8424PMID 17360518DOI 10.1073/PNAS.0608041104 Variant Set Distributions Mapped Variants
General Structure Information 3i4w DLG4 crystal structure of the third pdz domain of psd-95 1.35Å AUTH A.CAMARA-ARTIGAS,J.MURCIANO-CALLES,J.A.GAVIRA,E.S.COBOS,AUTH 2 J.C.MARTINEZTITL NOVEL CONFORMATIONAL ASPECTS OF THE THIRD PDZ DOMAIN OF THETITL 2 NEURONAL POST-SYNAPTIC DENSITY-95 PROTEIN REVEALED FROM TWOTITL 3 1.4A X-RAY STRUCTURESREF J.STRUCT.BIOL. V. 170 565 2010REFN ISSN 1047-8477PMID 20227506DOI 10.1016/J.JSB.2010.03.005 Variant Set Distributions Mapped Variants
General Structure Information 3ajb PEX3 crystal structure of human pex3p in complex with n-terminal pex19p peptide 2.5Å AUTH Y.SATO,H.SHIBATA,T.NAKATSU,H.NAKANO,Y.KASHIWAYAMA,T.IMANAKA,AUTH 2 H.KATOTITL STRUCTURAL BASIS FOR DOCKING OF PEROXISOMAL MEMBRANE PROTEINTITL 2 CARRIER PEX19P ONTO ITS RECEPTOR PEX3PREF EMBO J. V. 29 4083 2010REFN ISSN 0261-4189PMID 21102411DOI 10.1038/EMBOJ.2010.293 Variant Set Distributions Mapped Variants
General Structure Information 3jts B2M gy9-mamu-a*02-hb2m 2.8Å AUTH L.DAITITL STRUCTURE OF MAMU A*2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2wng SIRPA complete extracellular structure of human signal regulatory protein (sirp) alpha 2.49Å AUTH D.HATHERLEY,S.C.GRAHAM,K.HARLOS,D.I.STUART,AUTH 2 A.N.BARCLAYTITL STRUCTURE OF SIGNAL-REGULATORY PROTEIN ALPHA: ATITL 2 LINK TO ANTIGEN RECEPTOR EVOLUTION.REF J.BIOL.CHEM. V. 284 26613 2009REFN ISSN 0021-9258PMID 19628875DOI 10.1074/JBC.M109.017566 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 4guk NCS1 new crystal form structure of human ncs1 1.75Å AUTH F.CHENGPENG,L.ELIASTITL NEW CRYSTAL FORM STRUCTURE OF HUMAN NCS1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants