Assessment of Structural Intolerance and Durability
General Structure Information 2hyw ANXA2 human annexin a2 with calcium bound 2.1Å AUTH C.SHAO,F.ZHANG,M.M.KEMP,R.J.LINHARDT,D.M.WAISMAN,AUTH 2 J.F.HEAD,B.A.SEATONTITL CRYSTALLOGRAPHIC ANALYSIS OF CALCIUM-DEPENDENTTITL 2 HEPARIN BINDING TO ANNEXIN A2.REF J.BIOL.CHEM. V. 281 31689 2006REFN ISSN 0021-9258PMID 16882661DOI 10.1074/JBC.M604502200 Variant Set Distributions Mapped Variants
General Structure Information 1mmp MMP7 matrilysin complexed with carboxylate inhibitor 2.3Å AUTH M.F.BROWNER,W.W.SMITH,A.L.CASTELHANOTITL MATRILYSIN-INHIBITOR COMPLEXES: COMMON THEMESTITL 2 AMONG METALLOPROTEASES.REF BIOCHEMISTRY V. 34 6602 1995REFN ISSN 0006-2960PMID 7756291DOI 10.1021/BI00020A004 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1guh GSTA1 structure determination and refinement of human alpha class glutathione transferase a1-1, and a comparison with the mu and pi class enzymes 2.6Å AUTH I.SINNING,G.J.KLEYWEGT,S.W.COWAN,P.REINEMER,AUTH 2 H.W.DIRR,R.HUBER,G.L.GILLILAND,R.N.ARMSTRONG,X.JI,AUTH 3 P.G.BOARD,B.OLIN,B.MANNERVIK,T.A.JONESTITL STRUCTURE DETERMINATION AND REFINEMENT OF HUMANTITL 2 ALPHA CLASS GLUTATHIONE TRANSFERASE A1-1, AND ATITL 3 COMPARISON WITH THE MU AND PI CLASS […]
General Structure Information 1zmd DLD crystal structure of human dihydrolipoamide dehydrogenase complexed to nadh 2.08Å AUTH C.A.BRAUTIGAM,J.L.CHUANG,D.R.TOMCHICK,M.MACHIUS,AUTH 2 D.T.CHUANGTITL CRYSTAL STRUCTURE OF HUMAN DIHYDROLIPOAMIDETITL 2 DEHYDROGENASE: NAD+/NADH BINDING AND THETITL 3 STRUCTURAL BASIS OF DISEASE-CAUSING MUTATIONSREF J.MOL.BIOL. V. 350 543 2005REFN ISSN 0022-2836PMID 15946682DOI 10.1016/J.JMB.2005.05.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2dju PTPRF solution structures of the fn3 domain of human receptor- type tyrosine-protein phosphatase f -1.0Å AUTH M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE FN3 DOMAIN OF HUMANTITL 2 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE FREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2f3m GSTM1 structure of human glutathione s-transferase m1a-1a complexed with 1-(s-(glutathionyl)-2,4,6- trinitrocyclohexadienate anion 2.7Å AUTH Y.PATSKOVSKY,L.PATSKOVSKA,S.C.ALMO,I.LISTOWSKYTITL TRANSITION STATE MODEL AND MECHANISM OFTITL 2 NUCLEOPHILIC AROMATIC SUBSTITUTION REACTIONSTITL 3 CATALYZED BY HUMAN GLUTATHIONE S-TRANSFERASETITL 4 M1A-1A.REF BIOCHEMISTRY V. 45 3852 2006REFN ISSN 0006-2960PMID 16548513DOI 10.1021/BI051823+ Variant Set Distributions Mapped Variants
General Structure Information 1dsz RARA structure of the rxr/rar dna-binding domain heterodimer in complex with the retinoic acid response element dr1 1.7Å AUTH F.RASTINEJAD,T.WAGNER,Q.ZHAO,S.KHORASANIZADEHTITL STRUCTURE OF THE RXR-RAR DNA-BINDING COMPLEX ONTITL 2 THE RETINOIC ACID RESPONSE ELEMENT DR1.REF EMBO J. V. 19 1045 2000REFN ISSN 0261-4189PMID 10698945DOI 10.1093/EMBOJ/19.5.1045 Variant Set Distributions Mapped Variants
General Structure Information 1kyn CTSG cathepsin-g 3.5Å AUTH M.N.GRECO,M.J.HAWKINS,E.T.POWELL,H.R.ALMOND JR.,AUTH 2 T.W.CORCORAN,L.DE GARAVILLA,J.A.KAUFFMAN,R.RECACHA,AUTH 3 D.CHATTOPADHYAY,P.ANDRADE-GORDON,B.E.MARYANOFFTITL NONPEPTIDE INHIBITORS OF CATHEPSIN G: OPTIMIZATIONTITL 2 OF A NOVEL BETA-KETOPHOSPHONIC ACID LEAD BYTITL 3 STRUCTURE-BASED DRUG DESIGN.REF J.AM.CHEM.SOC. V. 124 3810 2002REFN ISSN 0002-7863PMID 11942800DOI 10.1021/JA017506H Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2wcy C7 nmr solution structure of factor i-like modules of complement c7. -1.0Å AUTH M.M.PHELAN,C.T.THAI,D.C.SOARES,R.T.OGATA,AUTH 2 P.N.BARLOW,J.BRAMHAMTITL SOLUTION STRUCTURE OF FACTOR I-LIKE MODULES FROMTITL 2 COMPLEMENT C7 REVEALS A PAIR OF FOLLISTATINTITL 3 DOMAINS IN COMPACT PSEUDOSYMMETRIC ARRANGEMENT.REF J.BIOL.CHEM. V. 284 19637 2009REFN ISSN 0021-9258PMID 19419965DOI 10.1074/JBC.M901993200 Variant Set Distributions Ripley’s K […]
General Structure Information 1gg3 EPB41 crystal structure of the protein 4.1r membrane binding domain 2.8Å AUTH B.G.HAN,W.NUNOMURA,Y.TAKAKUWA,N.MOHANDAS,B.K.JAPTITL PROTEIN 4.1R CORE DOMAIN STRUCTURE AND INSIGHTSTITL 2 INTO REGULATION OF CYTOSKELETAL ORGANIZATION.REF NAT.STRUCT.BIOL. V. 7 871 2000REFN ISSN 1072-8368PMID 11017195DOI 10.1038/82819 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants