Assessment of Structural Intolerance and Durability
General Structure Information 2x2u RET first two cadherin-like domains from human ret 2.0Å AUTH S.KJAER,S.HANRAHAN,N.TOTTY,N.Q.MCDONALDTITL MAMMAL-RESTRICTED ELEMENTS PREDISPOSE HUMAN RET TOTITL 2 FOLDING IMPAIRMENT BY HSCR MUTATIONS.REF NAT.STRUCT.MOL.BIOL. V. 17 726 2010REFN ISSN 1545-9993PMID 20473317DOI 10.1038/NSMB.1808 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3p1m FDX1 crystal structure of human ferredoxin-1 (fdx1) in complex with iron- sulfur cluster 2.54Å AUTH A.CHAIKUAD,C.JOHANSSON,T.KROJER,W.W.YUE,C.PHILLIPS,J.E.BRAY,AUTH 2 A.C.W.PIKE,J.R.C.MUNIZ,M.VOLLMAR,J.WEIGELT,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,C.BOUNTRA,K.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN FERREDOXIN-1 (FDX1) IN COMPLEXTITL 2 WITH IRON-SULFUR CLUSTERREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3cos ADH4 crystal structure of human class ii alcohol dehydrogenase (adh4) in complex with nad and zn 2.1Å AUTH K.L.KAVANAGH,N.SHAFQAT,W.YUE,F.VON DELFT,S.BISHOP,A.ROOS,AUTH 2 J.MURRAY,A.M.EDWARDS,C.H.ARROWSMITH,C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN CLASS II ALCOHOL DEHYDROGENASETITL 2 (ADH4) IN COMPLEX WITH NAD AND ZN.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2r4s ADRB2 crystal structure of the human beta2 adrenoceptor 3.4Å AUTH S.G.F.RASMUSSEN,H.J.CHOI,D.M.ROSENBAUM,T.S.KOBILKA,AUTH 2 F.S.THIAN,P.C.EDWARDS,M.BURGHAMMER,V.R.RATNALA,R.SANISHVILI,AUTH 3 R.F.FISCHETTI,G.F.SCHERTLER,W.I.WEIS,B.K.KOBILKATITL CRYSTAL STRUCTURE OF THE HUMAN BETA2 ADRENERGICTITL 2 G-PROTEIN-COUPLED RECEPTOR.REF NATURE V. 450 383 2007REFN ISSN 0028-0836PMID 17952055DOI 10.1038/NATURE06325 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4k9w CYP3A4 complex of human cyp3a4 with a desoxyritonavir analog 2.4Å AUTH I.F.SEVRIOUKOVA,T.L.POULOSTITL DISSECTING CYTOCHROME P450 3A4-LIGAND INTERACTIONS USINGTITL 2 RITONAVIR ANALOGUES.REF BIOCHEMISTRY V. 52 4474 2013REFN ISSN 0006-2960PMID 23746300DOI 10.1021/BI4005396 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4fm9 TOP2A human topoisomerase ii alpha bound to dna 2.9Å AUTH T.J.WENDORFF,B.H.SCHMIDT,P.HESLOP,C.A.AUSTIN,J.M.BERGERTITL THE STRUCTURE OF DNA-BOUND HUMAN TOPOISOMERASE II ALPHA:TITL 2 CONFORMATIONAL MECHANISMS FOR COORDINATING INTER-SUBUNITTITL 3 INTERACTIONS WITH DNA CLEAVAGE.REF J.MOL.BIOL. V. 424 109 2012REFN ISSN 0022-2836PMID 22841979DOI 10.1016/J.JMB.2012.07.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4lvt BCL2 bcl_2-navitoclax (abt-263) complex 2.05Å AUTH A.J.SOUERS,J.D.LEVERSON,E.R.BOGHAERT,S.L.ACKLER,N.D.CATRON,AUTH 2 J.CHEN,B.D.DAYTON,H.DING,S.H.ENSCHEDE,W.J.FAIRBROTHER,AUTH 3 D.C.HUANG,S.G.HYMOWITZ,S.JIN,S.L.KHAW,P.J.KOVAR,L.T.LAM,AUTH 4 J.LEE,H.L.MAECKER,K.C.MARSH,K.D.MASON,M.J.MITTEN,P.M.NIMMER,AUTH 5 A.OLEKSIJEW,C.H.PARK,C.M.PARK,D.C.PHILLIPS,A.W.ROBERTS,AUTH 6 D.SAMPATH,J.F.SEYMOUR,M.L.SMITH,G.M.SULLIVAN,S.K.TAHIR,AUTH 7 C.TSE,M.D.WENDT,Y.XIAO,J.C.XUE,H.ZHANG,R.A.HUMERICKHOUSE,AUTH 8 S.H.ROSENBERG,S.W.ELMORETITL ABT-199, A POTENT AND SELECTIVE BCL-2 INHIBITOR, ACHIEVESTITL 2 ANTITUMOR ACTIVITY WHILE SPARING PLATELETS.REF NAT.MED. (N.Y.) V. 19 202 2013REFN ISSN 1078-8956PMID 23291630DOI 10.1038/NM.3048 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1gmy CTSB cathepsin b complexed with dipeptidyl nitrile inhibitor 1.9Å AUTH P.D.GREENSPAN,K.L.CLARK,R.A.TOMMASI,S.D.COWEN,AUTH 2 L.W.MCQUIRE,D.L.FARLEY,J.H.VAN DUZER,R.L.GOLDBERG,AUTH 3 H.ZHOU,Z.DU,J.J.FITT,D.E.COPPA,Z.FANG,W.MACCHIA,AUTH 4 L.ZHU,M.P.CAPPARELLI,R.GOLDSTEIN,A.M.WIGG,AUTH 5 J.R.DOUGHTY,R.S BOHACEK,A.K.KNAPTITL IDENTIFICATION OF DIPEPTIDYL NITRILES AS POTENTTITL 2 AND SELECTIVE INHIBITORS OF CATHEPSIN B THROUGHTITL 3 STRUCTURE-BASED DRUG DESIGNREF J.MED.CHEM. V. 44 4524 2001REFN ISSN 0022-2623PMID 11741472DOI 10.1021/JM010206Q Variant Set Distributions […]
General Structure Information 2vct GSTA2 glutathione transferase a2-2 in complex with delta-4- andostrene-3-17-dione 2.1Å AUTH K.TARS,B.OLIN,B.MANNERVIKTITL STRUCTURAL BASIS FOR FEATURING OF STEROIDTITL 2 ISOMERASE ACTIVITY IN ALPHA CLASS GLUTATHIONETITL 3 TRANSFERASES.REF J.MOL.BIOL. V. 397 332 2010REFN ISSN 0022-2836PMID 20083122DOI 10.1016/J.JMB.2010.01.023 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1t2f LDHB human b lactate dehydrogenase complexed with nad+ and 4- hydroxy-1,2,5-oxadiazole-3-carboxylic acid 3.0Å AUTH A.CAMERON,J.READ,R.TRANTER,V.J.WINTER,R.B.SESSIONS,AUTH 2 R.L.BRADY,L.VIVAS,A.EASTON,H.KENDRICK,S.L.CROFT,AUTH 3 D.BARROS,J.L.LAVANDERA,J.J.MARTIN,F.RISCO,AUTH 4 S.GARCIA-OCHOA,F.J.GAMO,L.SANZ,L.LEON,J.R.RUIZ,AUTH 5 R.GABARRO,A.MALLO,F.G.DE LAS HERASTITL IDENTIFICATION AND ACTIVITY OF A SERIES OFTITL 2 AZOLE-BASED COMPOUNDS WITH LACTATETITL 3 DEHYDROGENASE-DIRECTED ANTI-MALARIAL ACTIVITY.REF J.BIOL.CHEM. V. 279 31429 2004REFN ISSN 0021-9258PMID 15117937DOI 10.1074/JBC.M402433200 Variant […]