Assessment of Structural Intolerance and Durability
General Structure Information 2k8o ITGAL solution structure of integrin alpha l -1.0Å AUTH A.BHUNIA,X.-Y.TANG,H.MOHANRAM,S.-M.TAN,AUTH 2 S.BHATTACHARJYATITL NMR SOLUTION CONFORMATIONS AND INTERACTIONS OFTITL 2 INTEGRIN {ALPHA}L{BETA}2 CYTOPLASMIC TAILSREF J.BIOL.CHEM. V. 284 3873 2009REFN ISSN 0021-9258PMID 19073598DOI 10.1074/JBC.M807236200 Variant Set Distributions Mapped Variants
General Structure Information 2nlk PTPRG crystal structure of d1 and d2 catalytic domains of human protein tyrosine phosphatase gamma (d1+d2 ptprg) 2.4Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1tuz DGKA nmr structure of the diacylglycerol kinase alpha, nesgc target hr532 -1.0Å AUTH G.LIU,Y.SHAO,R.XIAO,T.ACTON,G.T.MONTELIONE,AUTH 2 T.SZYPERSKITITL NMR STRUCTURE OF DIACYLGLYCEROL KINASE ALPHA,TITL 2 NESGC TARGET HR532REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2zoq MAPK3 structural dissection of human mitogen-activated kinase erk1 2.39Å AUTH T.KINOSHITA,I.YOSHIDA,S.NAKAE,K.OKITA,M.GOUDA,AUTH 2 M.MATSUBARA,K.YOKOTA,H.ISHIGURO,T.TADATITL CRYSTAL STRUCTURE OF HUMAN MONO-PHOSPHORYLATEDTITL 2 ERK1 AT TYR204REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 377 1123 2008REFN ISSN 0006-291XPMID 18983981DOI 10.1016/J.BBRC.2008.10.127 Variant Set Distributions Mapped Variants
General Structure Information 3qak ADORA2A agonist bound structure of the human adenosine a2a receptor 2.71Å AUTH F.XU,H.WU,V.KATRITCH,G.W.HAN,K.A.JACOBSON,Z.G.GAO,AUTH 2 V.CHEREZOV,R.C.STEVENSTITL STRUCTURE OF AN AGONIST-BOUND HUMAN A2A ADENOSINE RECEPTOR.REF SCIENCE V. 332 322 2011REFN ISSN 0036-8075PMID 21393508DOI 10.1126/SCIENCE.1202793 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3g33 CCND3 crystal structure of cdk4/cyclin d3 3.0Å AUTH T.TAKAKI,A.ECHALIER,N.R.BROWN,T.HUNT,J.A.ENDICOTT,M.E.NOBLETITL THE STRUCTURE OF CDK4/CYCLIN D3 HAS IMPLICATIONS FOR MODELSTITL 2 OF CDK ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 106 4171 2009REFN ISSN 0027-8424PMID 19237555DOI 10.1073/PNAS.0809674106 Variant Set Distributions Mapped Variants
General Structure Information 3h5c PROZ x-ray structure of protein z-protein z inhibitor complex 3.26Å AUTH X.HUANG,A.DEMENTIEV,S.T.OLSON,P.G.GETTINSTITL BASIS FOR THE SPECIFICITY AND ACTIVATION OF THE SERPINTITL 2 PROTEIN Z-DEPENDENT PROTEINASE INHIBITOR (ZPI) AS ANTITL 3 INHIBITOR OF MEMBRANE-ASSOCIATED FACTOR XA.REF J.BIOL.CHEM. V. 285 20399 2010REFN ISSN 0021-9258PMID 20427285DOI 10.1074/JBC.M110.112748 Variant Set Distributions Mapped Variants
General Structure Information 3szr MX1 crystal structure of modified nucleotide-free human mxa 3.5Å AUTH S.GAO,A.VON DER MALSBURG,A.DICK,K.FAELBER,G.F.SCHRODER,AUTH 2 O.HALLER,G.KOCHS,O.DAUMKETITL STRUCTURE OF MYXOVIRUS RESISTANCE PROTEIN A REVEALS INTRA-TITL 2 AND INTERMOLECULAR DOMAIN INTERACTIONS REQUIRED FOR THETITL 3 ANTIVIRAL FUNCTION.REF IMMUNITY V. 35 514 2011REFN ISSN 1074-7613PMID 21962493DOI 10.1016/J.IMMUNI.2011.07.012 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1uc6 CNTFR solution structure of the carboxyl terminal domain of the ciliary neurotrophic factor receptor -1.0Å AUTH D.MAN,W.HE,K.H.SZE,K.GONG,D.K.SMITH,G.ZHU,N.Y.IPTITL SOLUTION STRUCTURE OF THE C-TERMINAL DOMAIN OF THETITL 2 CILIARY NEUROTROPHIC FACTOR (CNTF) RECEPTOR ANDTITL 3 LIGAND FREE ASSOCIATIONS AMONG COMPONENTS OF THETITL 4 CNTF RECEPTOR COMPLEXREF J.BIOL.CHEM. V. 278 23285 2003REFN ISSN 0021-9258PMID […]
General Structure Information 1ry7 FGFR3 crystal structure of the 3 ig form of fgfr3c in complex with fgf1 3.2Å AUTH S.K.OLSEN,O.A.IBRAHIMI,A.RAUCCI,F.ZHANG,AUTH 2 A.V.ELISEENKOVA,A.YAYON,C.BASILICO,R.J.LINHARDT,AUTH 3 J.SCHLESSINGER,M.MOHAMMADITITL INSIGHTS INTO THE MOLECULAR BASIS FOR FIBROBLASTTITL 2 GROWTH FACTOR RECEPTOR AUTOINHIBITION ANDTITL 3 LIGAND-BINDING PROMISCUITY.REF PROC.NATL.ACAD.SCI.USA V. 101 935 2004REFN ISSN 0027-8424PMID 14732692DOI 10.1073/PNAS.0307287101 Variant Set Distributions Ripley’s K […]