Assessment of Structural Intolerance and Durability
General Structure Information 2qk4 GART human glycinamide ribonucleotide synthetase 2.45Å AUTH M.WELIN,J.G.GROSSMANN,S.FLODIN,T.NYMAN,P.STENMARK,AUTH 2 L.TRESAUGUES,T.KOTENYOVA,I.JOHANSSON,P.NORDLUND,L.LEHTIOTITL STRUCTURAL STUDIES OF TRI-FUNCTIONAL HUMAN GART.REF NUCLEIC ACIDS RES. V. 38 7308 2010REFN ISSN 0305-1048PMID 20631005DOI 10.1093/NAR/GKQ595 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3zjd TNFAIP3 a20 otu domain in reduced, active state at 1.87 a resolution 1.87Å AUTH Y.KULATHU,F.J.GARCIA,T.E.T.MEVISSEN,M.BUSCH,N.ARNAUDO,AUTH 2 K.S.CARROLL,D.BARFORD,D.KOMANDERTITL REGULATION OF A20 AND OTHER OTU DEUBIQUITINASES BYTITL 2 REVERSIBLE OXIDATIONREF NAT.COMMUN. V. 4 1569 2013REFN ISSN 2041-1723PMID 23463012DOI 10.1038/NCOMMS2567 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1vec DDX6 crystal structure of the n-terminal domain of rck/p54, a human dead-box protein 2.01Å AUTH T.MATSUI,K.HOGETSU,J.USUKURA,T.SATO,T.KUMASAKA,AUTH 2 Y.AKAO,N.TANAKATITL STRUCTURAL INSIGHT OF HUMAN DEAD-BOX PROTEINTITL 2 RCK/P54 INTO ITS SUBSTRATE RECOGNITION WITHTITL 3 CONFORMATIONAL CHANGESREF GENES CELLS V. 11 439 2006REFN ISSN 1356-9597PMID 16611246DOI 10.1111/J.1365-2443.2006.00951.X Variant Set Distributions Mapped Variants
General Structure Information 6pax PAX6 crystal structure of the human pax-6 paired domain-dna complex reveals a general model for pax protein-dna interactions 2.5Å AUTH H.E.XU,M.A.ROULD,W.XU,J.A.EPSTEIN,R.L.MAAS,C.O.PABOTITL CRYSTAL STRUCTURE OF THE HUMAN PAX6 PAIREDTITL 2 DOMAIN-DNA COMPLEX REVEALS SPECIFIC ROLES FOR THETITL 3 LINKER REGION AND CARBOXY-TERMINAL SUBDOMAIN INTITL 4 DNA BINDING.REF GENES DEV. V. 13 1263 […]
General Structure Information 2eqe TNFAIP3 solution structure of the fourth a20-type zinc finger domain from human tumor necrosis factor, alpha-induced protein3 -1.0Å AUTH H.P.ZHANG,T.NAGASIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FOURTH A20-TYPE ZINCTITL 2 FINGER DOMAIN FROM HUMAN TUMOR NECROSIS FACTOR,TITL 3 ALPHA-INDUCED PROTEIN3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1fuj PRTN3 pr3 (myeloblastin) 2.2Å AUTH M.FUJINAGA,M.M.CHERNAIA,R.HALENBECK,K.KOTHS,M.N.JAMESTITL THE CRYSTAL STRUCTURE OF PR3, A NEUTROPHIL SERINE PROTEINASETITL 2 ANTIGEN OF WEGENERS GRANULOMATOSIS ANTIBODIES.REF J.MOL.BIOL. V. 261 267 1996REFN ISSN 0022-2836PMID 8757293DOI 10.1006/JMBI.1996.0458 Variant Set Distributions Mapped Variants
General Structure Information 1ovz FCAR crystal structure of human fcari 3.0Å AUTH A.B.HERR,E.R.BALLISTER,P.J.BJORKMANTITL INSIGHTS INTO IGA-MEDIATED IMMUNE RESPONSES FROM THE CRYSTALTITL 2 STRUCTURES OF HUMAN FC-ALPHA-RI AND ITS COMPLEX WITH IGA1-FCREF NATURE V. 423 614 2003REFN ISSN 0028-0836PMID 12768205DOI 10.1038/NATURE01685 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1uqs CD1B the crystal structure of human cd1b with a bound bacterial glycolipid 3.1Å AUTH T.BATUWANGALA,D.SHEPHERD,S.D.GADOLA,K.J.C.GIBSON,AUTH 2 N.R.ZACCAI,A.R.FERSHT,G.S.BESRA,V.CERUNDOLO,AUTH 3 E.Y.JONESTITL THE CRYSTAL STRUCTURE OF HUMAN CD1B WITH A BOUNDTITL 2 BACTERIAL GLYCOLIPIDREF J.IMMUNOL. V. 172 2382 2004REFN ISSN 0022-1767PMID 14764708 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1x0j BRD2 crystal structure analysis of the n-terminal bromodomain of human brd2 1.8Å AUTH Y.NAKAMURA,T.UMEHARA,M.SHIROUZU,B.PADMANABHAN,AUTH 2 S.YOKOYAMATITL STRUCTURAL BASIS FOR ACETYLATED HISTONE H4TITL 2 RECOGNITION BY THE HUMAN BRD2 BROMODOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ov6 B2M cd1c in complex with mpm (mannosyl-beta1-phosphomycoketide) 2.5Å AUTH L.SCHARF,N.S.LI,A.J.HAWK,D.GARZON,T.ZHANG,L.M.FOX,A.R.KAZEN,AUTH 2 S.SHAH,E.J.HADDADIAN,J.E.GUMPERZ,A.SAGHATELIAN,AUTH 3 J.D.FARALDO-GOMEZ,S.C.MEREDITH,J.A.PICCIRILLI,E.J.ADAMSTITL THE 2.5 A STRUCTURE OF CD1C IN COMPLEX WITH A MYCOBACTERIALTITL 2 LIPID REVEALS AN OPEN GROOVE IDEALLY SUITED FOR DIVERSETITL 3 ANTIGEN PRESENTATIONREF IMMUNITY V. 33 853 2010REFN ISSN 1074-7613PMID 21167756DOI 10.1016/J.IMMUNI.2010.11.026 Variant Set Distributions Mapped […]