Assessment of Structural Intolerance and Durability
General Structure Information 3wef FDFT1 crystal structure of the human squalene synthase in complex with farnesyl thiopyrophosphate 2.35Å AUTH C.I.LIU,W.Y.JENG,W.J.CHANG,M.F.SHIH,T.P.KO,A.H.J.WANGTITL STRUCTURAL INSIGHTS INTO THE CATALYTIC MECHANISM OF HUMANTITL 2 SQUALENE SYNTHASEREF ACTA CRYSTALLOGR.,SECT.D V. 70 231 2014REFN ISSN 0907-4449DOI 10.1107/S1399004713026230 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4k5y CRHR1 crystal structure of human corticotropin-releasing factor receptor 1 (crf1r) in complex with the antagonist cp-376395 2.98Å AUTH K.HOLLENSTEIN,J.KEAN,A.BORTOLATO,R.K.CHENG,A.S.DORE,AUTH 2 A.JAZAYERI,R.M.COOKE,M.WEIR,F.H.MARSHALLTITL STRUCTURE OF CLASS B GPCR CORTICOTROPIN-RELEASING FACTORTITL 2 RECEPTOR 1.REF NATURE V. 499 438 2013REFN ISSN 0028-0836PMID 23863939DOI 10.1038/NATURE12357 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4l3v CBS crystal structure of delta516-525 human cystathionine beta-synthase 3.63Å AUTH J.ERENO-ORBEA,T.MAJTAN,I.OYENARTE,J.P.KRAUS,AUTH 2 L.A.MARTINEZ-CRUZTITL STRUCTURAL BASIS OF REGULATION AND OLIGOMERIZATION OF HUMANTITL 2 CYSTATHIONINE BETA-SYNTHASE, THE CENTRAL ENZYME OFTITL 3 TRANSSULFURATION.REF PROC.NATL.ACAD.SCI.USA V. 110 E3790 2013REFN ISSN 0027-8424PMID 24043838DOI 10.1073/PNAS.1313683110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4ip7 PKLR structure of the s12d variant of human liver pyruvate kinase in complex with citrate and fbp. 1.8Å AUTH T.HOLYOAK,B.ZHANG,J.DENG,Q.TANG,C.B.PRASANNAN,A.W.FENTONTITL ENERGETIC COUPLING BETWEEN AN OXIDIZABLE CYSTEINE AND THETITL 2 PHOSPHORYLATABLE N-TERMINUS OF HUMAN LIVER PYRUVATE KINASE.REF BIOCHEMISTRY V. 52 466 2013REFN ISSN 0006-2960PMID 23270483DOI 10.1021/BI301341R Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2grr RANGAP1 crystal structure of human rangap1-ubc9-d127s 1.3Å AUTH A.A.YUNUS,C.D.LIMATITL LYSINE ACTIVATION AND FUNCTIONAL ANALYSIS OFTITL 2 E2-MEDIATED CONJUGATION IN THE SUMO PATHWAY.REF NAT.STRUCT.MOL.BIOL. V. 13 491 2006REFN ISSN 1545-9993PMID 16732283DOI 10.1038/NSMB1104 Variant Set Distributions Mapped Variants
General Structure Information 1khb PCK1 pepck complex with nonhydrolyzable gtp analog, native data 1.85Å AUTH P.DUNTEN,C.BELUNIS,R.CROWTHER,K.HOLLFELDER,AUTH 2 U.KAMMLOTT,W.LEVIN,H.MICHEL,G.B.RAMSEY,A.SWAIN,AUTH 3 D.WEBER,S.J.WERTHEIMERTITL CRYSTAL STRUCTURE OF HUMAN CYTOSOLICTITL 2 PHOSPHOENOLPYRUVATE CARBOXYKINASE REVEALS A NEWTITL 3 GTP-BINDING SITE.REF J.MOL.BIOL. V. 316 257 2002REFN ISSN 0022-2836PMID 11851336DOI 10.1006/JMBI.2001.5364 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2rd0 PIK3CA structure of a human p110alpha/p85alpha complex 3.05Å AUTH C.H.HUANG,D.MANDELKER,O.SCHMIDT-KITTLER,Y.SAMUELS,AUTH 2 V.E.VELCULESCU,K.W.KINZLER,B.VOGELSTEIN,S.B.GABELLI,AUTH 3 L.M.AMZELTITL THE STRUCTURE OF A HUMAN P110ALPHA/P85ALPHA COMPLEXTITL 2 ELUCIDATES THE EFFECTS OF ONCOGENIC PI3KALPHA MUTATIONS.REF SCIENCE V. 318 1744 2007REFN ISSN 0036-8075PMID 18079394DOI 10.1126/SCIENCE.1150799 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2lul TEC solution nmr structure of ph domain of tyrosine-protein kinase tec from homo sapiens, northeast structural genomics consortium (nesg) target hr3504c -1.0Å AUTH G.LIU,R.XIAO,H.JANJUA,K.HAMILTON,R.SHASTRY,E.KOHAN,AUTH 2 T.B.ACTON,J.K.EVERETT,H.LEE,K.PEDERSON,Y.J.HUANG,AUTH 3 G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF PH DOMAIN OF TYROSINE-PROTEINTITL 2 KINASE TEC FROM HOMO SAPIENS, NORTHEAST STRUCTURAL GENOMICSTITL 3 CONSORTIUM (NESG) TARGET HR3504CREF TO […]
General Structure Information 4c9b EIF4A3 crystal structure of eif4aiii-cwc22 complex 2.0Å AUTH G.BUCHWALD,S.SCHUESSLER,C.BASQUIN,H.LE HIR,E.CONTITITL CRYSTAL STRUCTURE OF THE HUMAN EIF4AIII-CWC22 COMPLEX SHOWSTITL 2 HOW A DEAD-BOX PROTEIN IS INHIBITED BY A MIF4G DOMAINREF PROC.NATL.ACAD.SCI.USA V. 110 E4611 2013REFN ISSN 0027-8424PMID 24218557DOI 10.1073/PNAS.1314684110 Variant Set Distributions Mapped Variants
General Structure Information 2l7z HOXA13 nmr structure of a13 homedomain -1.0Å AUTH Y.ZHANG,C.A.LARSEN,H.S.STADLER,J.B.AMESTITL STRUCTURAL BASIS FOR SEQUENCE SPECIFIC DNA BINDING ANDTITL 2 PROTEIN DIMERIZATION OF HOXA13.REF PLOS ONE V. 6 23069 2011REFN ESSN 1932-6203PMID 21829694DOI 10.1371/JOURNAL.PONE.0023069 Variant Set Distributions Mapped Variants