Assessment of Structural Intolerance and Durability
General Structure Information 3r2w UGP2 crystal strucutre of udp-glucose pyrophosphorylase of homo sapiens 3.6Å AUTH Q.YU,X.ZHENGTITL THE CRYSTAL STRUCTURE OF HUMAN UDP-GLUCOSE PYROPHOSPHORYLASETITL 2 REVEALS A LATCH EFFECT THAT INFLUENCES ENZYMATIC ACTIVITY.REF BIOCHEM.J. V. 442 283 2012REFN ISSN 0264-6021PMID 22132858DOI 10.1042/BJ20111598 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2xt3 KIF7 human kif7, a kinesin involved in hedgehog signalling 1.88Å AUTH M.KLEJNOT,F.KOZIELSKITITL STRUCTURAL INSIGHTS INTO HUMAN KIF7, A KINESIN INVOLVED INTITL 2 HEDGEHOG SIGNALLING.REF ACTA CRYSTALLOGR.,SECT.D V. 68 154 2012REFN ISSN 0907-4449PMID 22281744DOI 10.1107/S0907444911053042 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2yuh TBCC solution structure of the c-terminal region in human tubulin folding cofactor c -1.0Å AUTH K.SAITO,N.TOCHIO,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C-TERMINAL REGION INTITL 2 HUMAN TUBULIN FOLDING COFACTOR CREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ld6 CYP51A1 crystal structure of human lanosterol 14alpha-demethylase (cyp51) in complex with ketoconazole 2.8Å AUTH N.STRUSHKEVICH,S.A.USANOV,H.W.PARKTITL STRUCTURAL BASIS OF HUMAN CYP51 INHIBITION BY ANTIFUNGALTITL 2 AZOLES.REF J.MOL.BIOL. V. 397 1067 2010REFN ISSN 0022-2836PMID 20149798DOI 10.1016/J.JMB.2010.01.075 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3b6y IFI16 crystal structure of the second hin-200 domain of interferon-inducible protein 16 2.35Å AUTH J.C.C.LIAO,R.LAM,M.RAVICHANDRAN,S.DUAN,W.TEMPEL,AUTH 2 N.Y.CHIRGADZE,C.H.ARROWSMITHTITL CRYSTAL STRUCTURE ANALYSIS OF THE SECOND HIN DOMAIN OFTITL 2 IFI16.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3aqf CALCRL crystal structure of the human crlr/ramp2 extracellular complex 2.6Å AUTH S.KUSANO,M.KUKIMOTO-NIINO,N.HINO,N.OHSAWA,K.OKUDA,AUTH 2 K.SAKAMOTO,M.SHIROUZU,T.SHINDO,S.YOKOYAMATITL STRUCTURAL BASIS FOR EXTRACELLULAR INTERACTIONS BETWEENTITL 2 CALCITONIN RECEPTOR-LIKE RECEPTOR AND RECEPTORTITL 3 ACTIVITY-MODIFYING PROTEIN 2 FOR ADRENOMEDULLIN-SPECIFICTITL 4 BINDINGREF PROTEIN SCI. V. 21 199 2012REFN ISSN 0961-8368PMID 22102369DOI 10.1002/PRO.2003 Variant Set Distributions Mapped Variants
General Structure Information 2uyy GLYR1 structure of the cytokine-like nuclear factor n-pac 2.5Å AUTH J.TICKLE,E.S.PILKA,G.BUNKOCZI,G.BERRIDGE,C.SMEE,AUTH 2 K.L.KAVANAGH,V.HOZJAN,F.H.NIESEN,E.PAPAGRIGORIOU,A.C.W.PIKE,AUTH 3 A.TURNBULL,C.H.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 4 F.VON DELFT,U.OPPERMANNTITL THE STRUCTURE OF THE CYTOKINE-LIKE NUCLEAR FACTOR N-PACREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4boq YOD1 structure of otud2 otu domain 1.47Å AUTH T.E.T.MEVISSEN,M.K.HOSPENTHAL,P.P.GEURINK,P.R.ELLIOTT,AUTH 2 M.AKUTSU,N.ARNAUDO,R.EKKEBUS,Y.KULATHU,T.WAUER,F.EL OUALID,AUTH 3 S.M.V.FREUND,H.OVAA,D.KOMANDERTITL OTU DEUBIQUITINASES REVEAL MECHANISMS OF LINKAGETITL 2 SPECIFICITY AND ENABLE UBIQUITIN CHAIN RESTRICTIONTITL 3 ANALYSIS.REF CELL(CAMBRIDGE,MASS.) V. 154 169 2013REFN ISSN 0092-8674PMID 23827681DOI 10.1016/J.CELL.2013.05.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2edh OBSCN solution structure of the pdz domain (3614- 3713 ) from human obscurin -1.0Å AUTH H.ENDO,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PDZ DOMAIN (3614 – 3713 ) FROMTITL 2 HUMAN OBSCURINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3eij PDCD4 crystal structure of pdcd4 2.8Å AUTH P.G.LOH,H.-S.YANG,M.A.WALSH,Q.WANG,X.WANG,Z.CHENG,D.LIU,AUTH 2 H.SONGTITL STRUCTURAL BASIS FOR TRANSLATIONAL INHIBITION BY THE TUMOURTITL 2 SUPPRESSOR PDCD4REF EMBO J. V. 28 274 2009REFN ISSN 0261-4189PMID 19153607DOI 10.1038/EMBOJ.2008.278 Variant Set Distributions Mapped Variants