Assessment of Structural Intolerance and Durability
General Structure Information 1wjr SFMBT2 solution structure of the 2nd mbt domain from human kiaa1617 protein -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 2ND MBT DOMAIN FROMTITL 2 HUMAN KIAA1617 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2hdh HADH biochemical characterization and structure determination of human heart short chain l-3-hydroxyacyl coa dehydrogenase provide insight into catalytic mechanism 2.2Å AUTH J.J.BARYCKI,L.K.OBRIEN,J.M.BRATT,R.ZHANG,R.SANISHVILI,AUTH 2 A.W.STRAUSS,L.J.BANASZAKTITL BIOCHEMICAL CHARACTERIZATION AND CRYSTAL STRUCTURETITL 2 DETERMINATION OF HUMAN HEART SHORT CHAIN L-3-HYDROXYACYL-COATITL 3 DEHYDROGENASE PROVIDE INSIGHTS INTO CATALYTIC MECHANISM.REF BIOCHEMISTRY V. 38 5786 1999REFN ISSN 0006-2960PMID […]
General Structure Information 4ah6 DARS2 human mitochondrial aspartyl-trna synthetase 3.7Å AUTH E.ENNIFAR,C.FLORENTZ,A.GAUDRY,B.LORBER,A.NEUENFELDT,AUTH 2 C.SAUTER,M.SISSLERTITL THERMODYNAMIC PROPERTIES DISTINGUISH HUMAN MITOCHONDRIALTITL 2 ASPARTYL-TRNA SYNTHETASE FROM BACTERIAL HOMOLOG WITH SAMETITL 3 3D ARCHITECTUREREF NUCLEIC ACIDS RES. V. 41 2698 2013REFN ISSN 0305-1048PMID 23275545DOI 10.1093/NAR/GKS1322 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3bo5 SETMAR crystal structure of methyltransferase domain of human histone-lysine n-methyltransferase setmar 1.59Å AUTH H.WU,V.V.LUNIN,H.REN,E.DOBROVETSKY,J.WEIGELT,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,J.MIN,A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMANTITL 2 HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR IN COMPLEX WITHTITL 3 ADOHCY.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1khu SMAD1 smad1 crystal structure reveals the details of bmp signaling pathway 2.5Å AUTH B.Y.QIN,B.M.CHACKO,S.S.LAM,M.P.DE CAESTECKER,AUTH 2 J.J.CORREIA,K.LINTITL STRUCTURAL BASIS OF SMAD1 ACTIVATION BY RECEPTORTITL 2 KINASE PHOSPHORYLATION.REF MOL.CELL V. 8 1303 2001REFN ISSN 1097-2765PMID 11779505DOI 10.1016/S1097-2765(01)00417-8 Variant Set Distributions Mapped Variants
General Structure Information 2nt2 SSH2 crystal structure of slingshot phosphatase 2 2.1Å AUTH S.K.JUNG,D.G.JEONG,T.S.YOON,J.H.KIM,S.E.RYU,S.J.KIMTITL CRYSTAL STRUCTURE OF HUMAN SLINGSHOT PHOSPHATASE 2.REF PROTEINS V. 68 408 2007REFN ISSN 0887-3585PMID 17427953DOI 10.1002/PROT.21399 Variant Set Distributions Mapped Variants
General Structure Information 2cfy TXNRD1 crystal structure of human thioredoxin reductase 1 2.7Å AUTH J.E.DEBRECZENI,C.JOHANSSON,K.KAVANAGH,P.SAVITSKY,AUTH 2 M.SUNDSTROM,C.ARROWSMITH,J.WEIGELT,A.EDWARDS,F.VON DELFT,AUTH 3 U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN THIOREDOXIN REDUCTASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2afo QPCT crystal structure of human glutaminyl cyclase at ph 8.0 2.35Å AUTH K.F.HUANG,Y.L.LIU,W.J.CHENG,T.P.KO,A.H.WANGTITL CRYSTAL STRUCTURES OF HUMAN GLUTAMINYL CYCLASE, AN ENZYMETITL 2 RESPONSIBLE FOR PROTEIN N-TERMINAL PYROGLUTAMATE FORMATIONREF PROC.NATL.ACAD.SCI.USA V. 102 13117 2005REFN ISSN 0027-8424PMID 16135565DOI 10.1073/PNAS.0504184102 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3of6 PTCRA human pre-t cell receptor crystal structure 2.8Å AUTH S.S.PANG,R.BERRY,Z.CHEN,L.KJER-NIELSEN,M.A.PERUGINI,AUTH 2 G.F.KING,C.WANG,S.H.CHEW,N.L.LA GRUTA,N.K.WILLIAMS,T.BEDDOE,AUTH 3 T.TIGANIS,N.P.COWIESON,D.I.GODFREY,A.W.PURCELL,M.C.J.WILCE,AUTH 4 J.MCCLUSKEY,J.ROSSJOHNTITL THE STRUCTURAL BASIS FOR AUTONOMOUS DIMERIZATION OF THETITL 2 PRE-T-CELL ANTIGEN RECEPTORREF NATURE V. 467 844 2010REFN ISSN 0028-0836PMID 20944746DOI 10.1038/NATURE09448 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4nj4 ALKBH5 crystal structure of human alkbh5 2.02Å AUTH W.AIK,J.S.SCOTTI,H.CHOI,L.GONG,M.DEMETRIADES,C.J.SCHOFIELD,AUTH 2 M.A.MCDONOUGHTITL STRUCTURE OF HUMAN RNA N6-METHYLADENINE DEMETHYLASE ALKBH5TITL 2 PROVIDES INSIGHTS INTO ITS MECHANISMS OF NUCLEIC ACIDTITL 3 RECOGNITION AND DEMETHYLATION.REF NUCLEIC ACIDS RES. V. 42 4741 2014REFN ISSN 0305-1048PMID 24489119DOI 10.1093/NAR/GKU085 Variant Set Distributions Mapped Variants