Assessment of Structural Intolerance and Durability
General Structure Information 4h10 ARNTL intermolecular recognition revealed by the complex structure of human clock-bmal1 basic helix-loop-helix domains with e-box dna 2.4Å AUTH Z.WANG,Y.WU,L.LI,X.D.SUTITL INTERMOLECULAR RECOGNITION REVEALED BY THE COMPLEX STRUCTURETITL 2 OF HUMAN CLOCK-BMAL1 BASIC HELIX-LOOP-HELIX DOMAINS WITHTITL 3 E-BOX DNA.REF CELL RES. V. 23 213 2013REFN ISSN 1001-0602PMID 23229515DOI 10.1038/CR.2012.170 Variant Set Distributions […]
General Structure Information 2f60 PDHX crystal structure of the dihydrolipoamide dehydrogenase (e3)-binding domain of human e3-binding protein 1.55Å AUTH C.A.BRAUTIGAM,R.M.WYNN,J.L.CHUANG,M.MACHIUS,D.R.TOMCHICK,AUTH 2 D.T.CHUANGTITL STRUCTURAL INSIGHT INTO INTERACTIONS BETWEENTITL 2 DIHYDROLIPOAMIDE DEHYDROGENASE (E3) AND E3 BINDING PROTEINTITL 3 OF HUMAN PYRUVATE DEHYDROGENASE COMPLEX.REF STRUCTURE V. 14 611 2006REFN ISSN 0969-2126PMID 16442803DOI 10.1016/J.STR.2006.01.001 Variant Set Distributions Mapped Variants
General Structure Information 2ooq PTPRT crystal structure of the human receptor phosphatase ptprt 1.8Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1wie RIMBP2 solution structure of the first sh3 domain of kiaa0318 protein -1.0Å AUTH K.INOUE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST SH3 DOMAIN OFTITL 2 KIAA0318 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2kkr ATXN7 solution structure of sca7 zinc finger domain from human ataxin-7 protein -1.0Å AUTH J.BONNET,Y.WANG,A.ATKINSON,J.KOFFLER,C.ROMIER,A.HAMICHE,AUTH 2 L.TORA,D.DEVYS,B.KIEFFERTITL HISTONE DEUBIQUITINATION BY SAGA IS MODULATED BY ANTITL 2 ATYPICAL ZINC FINGER DOMAIN OF ATAXIN-7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4a1g BUB1 the crystal structure of the human bub1 tpr domain in complex with the ki motif of knl1 2.6Å AUTH V.KRENN,A.WEHENKEL,X.LI,S.SANTAGUIDA,A.MUSACCHIOTITL STRUCTURAL ANALYSIS REVEALS FEATURES OF THE SPINDLETITL 2 CHECKPOINT KINASE BUB1-KINETOCHORE SUBUNIT KNL1TITL 3 INTERACTION.REF J.CELL BIOL. V. 196 451 2012REFN ISSN 0021-9525PMID 22331848DOI 10.1083/JCB.201110013 Variant Set Distributions Mapped Variants
General Structure Information 1wh8 CUX2 solution structure of the third cut domain of human homeobox protein cux-2 -1.0Å AUTH N.NAMEKI,N.TOCHIO,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD CUT DOMAIN OFTITL 2 HUMAN HOMEOBOX PROTEIN CUX-2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ebz RGS12 solution structure of the rgs domain from human regulator of g-protein signaling 12 (rgs12) -1.0Å AUTH H.P.ZHANG,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RGS DOMAIN FROM HUMANTITL 2 REGULATOR OF G-PROTEIN SIGNALING 12 (RGS12)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3keu PDXK crystal structure of human pl kinase with bound plp and atp 2.1Å AUTH A.K.GANDHI,F.N.MUSAYEV,M.K.SAFOTITL CRYSTAL STRUCTURE OF PL KINASE IN COMPLEX WITH MGATP ANDTITL 2 PLP: STRUCTURAL BASIS OF SEVERE INDUCED MGATP SUBSTRATETITL 3 INHIBITION OF THE ENZYMEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1wjm SPTBN2 solution structure of pleckstrin homology domain of human beta iii spectrin. -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF PLECKSTRIN HOMOLOGY DOMAINTITL 2 OF HUMAN BETA III SPECTRINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants