Assessment of Structural Intolerance and Durability
General Structure Information 1wlx ACTN4 solution structure of the third spectrin repeat of alpha- actinin-4 -1.0Å AUTH K.KOWALSKI,A.L.MERKEL,G.W.BOOKERTITL SOLUTION STRUCTURE OF THE THIRD SPECTRIN REPEAT OFTITL 2 ALPHA-ACTININ-4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1mzw PPIH crystal structure of a u4/u6 snrnp complex between human spliceosomal cyclophilin h and a u4/u6-60k peptide 2.0Å AUTH U.REIDT,M.C.WAHL,D.FASSHAUER,D.S.HOROWITZ,AUTH 2 R.LUEHRMANN,R.FICNERTITL CRYSTAL STRUCTURE OF A COMPLEX BETWEEN HUMANTITL 2 SPLICEOSOMAL CYCLOPHILIN H AND A U4/U6 SNRNP-60KTITL 3 PEPTIDEREF J.MOL.BIOL. V. 331 45 2003REFN ISSN 0022-2836PMID 12875835DOI 10.1016/S0022-2836(03)00684-3 Variant Set Distributions […]
General Structure Information 2do3 SUPT5H solution structure of the third kow motif of transcription elongation factor spt5 -1.0Å AUTH S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD KOW MOTIF OFTITL 2 TRANSCRIPTION ELONGATION FACTOR SPT5REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2d9k TRAFD1 solution structure of the zf-traf domain of fln29 gene product -1.0Å AUTH T.SUETAKE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZF-TRAF DOMAIN OF FLN29TITL 2 GENE PRODUCTREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2cru PDCD5 solution structure of programmed cell death 5 -1.0Å AUTH T.NAGASHIMA,K.IZUMI,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF PROGRAMMED CELL DEATH 5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4c8b RIPK2 structure of the kinase domain of human ripk2 in complex with ponatinib 2.75Å AUTH P.CANNING,A.BULLOCKTITL STRUCTURE OF THE KINASE DOMAIN OF HUMAN RIPK2 IN COMPLEXTITL 2 WITH PONATINIBREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2qqm NRP1 crystal structure of the a2b1b2 domains from human neuropilin-1 2.0Å AUTH B.A.APPLETON,P.WU,J.MALONEY,J.YIN,W.C.LIANG,S.STAWICKI,AUTH 2 K.MORTARA,K.K.BOWMAN,J.M.ELLIOTT,W.DESMARAIS,J.F.BAZAN,AUTH 3 A.BAGRI,M.TESSIER-LAVIGNE,A.W.KOCH,Y.WU,R.J.WATTS,C.WIESMANNTITL STRUCTURAL STUDIES OF NEUROPILIN/ANTIBODY COMPLEXES PROVIDETITL 2 INSIGHTS INTO SEMAPHORIN AND VEGF BINDINGREF EMBO J. V. 26 4902 2007REFN ISSN 0261-4189PMID 17989695DOI 10.1038/SJ.EMBOJ.7601906 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1zrh HS3ST1 crystal structure of human heparan sulfate glucosamine 3-o- sulfotransferase 1 in complex with pap 2.1Å AUTH A.DONG,L.DOMBROVSKI,P.LOPPNAU,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 A.N.PLOTNIKOVTITL CRYSTAL STRUCTURE OF HUMAN HEPARAN SULFATETITL 2 GLUCOSAMINE 3-O-SULFOTRANSFERASE 1 IN COMPLEX WITHTITL 3 PAPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4eyj MAPK13 mapk13 complex with inhibitor 2.1Å AUTH Y.G.ALEVY,A.C.PATEL,A.G.ROMERO,D.A.PATEL,J.TUCKER,AUTH 2 W.T.ROSWIT,C.A.MILLER,R.F.HEIER,D.E.BYERS,T.J.BRETT,AUTH 3 M.J.HOLTZMANTITL IL-13-INDUCED AIRWAY MUCUS PRODUCTION IS ATTENUATED BYTITL 2 MAPK13 INHIBITION.REF J.CLIN.INVEST. V. 122 4555 2012REFN ISSN 0021-9738PMID 23187130DOI 10.1172/JCI64896 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1jbi COCH nmr structure of the lccl domain -1.0Å AUTH E.LIEPINSH,M.TREXLER,A.KAIKKONEN,J.WEIGELT,AUTH 2 L.BANYAI,L.PATTHY,G.OTTINGTITL NMR STRUCTURE OF THE LCCL DOMAIN AND IMPLICATIONSTITL 2 FOR DFNA9 DEAFNESS DISORDER.REF EMBO J. V. 20 5347 2001REFN ISSN 0261-4189PMID 11574466DOI 10.1093/EMBOJ/20.19.5347 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants