Assessment of Structural Intolerance and Durability
General Structure Information 1uvg SPINK5 solution structure of the 15th domain of lekti -1.0Å AUTH H.TIDOW,T.LAUBER,K.VITZITHUM,C.SOMMERHOFF,P.ROESCH,AUTH 2 U.C.MARXTITL THE SOLUTION STRUCTURE OF A CHIMERIC LEKTI DOMAINTITL 2 REVEALS A CHAMELEON SEQUENCEREF BIOCHEMISTRY V. 43 11238 2004REFN ISSN 0006-2960PMID 15366933DOI 10.1021/BI0492399 Variant Set Distributions Mapped Variants
General Structure Information 1wvo NANS solution structure of rsgi ruh-029, an antifreeze protein like domain in human n-acetylneuraminic acid phosphate synthase gene. -1.0Å AUTH T.HAMADA,Y.ITO,T.ABE,F.HAYASHI,P.GUNTERT,M.INOUE,AUTH 2 T.KIGAWA,T.TERADA,M.SHIROUZU,M.YOSHIDA,A.TANAKA,AUTH 3 S.SUGANO,S.YOKOYAMA,H.HIROTATITL SOLUTION STRUCTURE OF THE ANTIFREEZE-LIKE DOMAINTITL 2 OF HUMAN SIALIC ACID SYNTHASEREF PROTEIN SCI. V. 15 1010 2006REFN ISSN 0961-8368PMID 16597820DOI 10.1110/PS.051700406 Variant Set Distributions Mapped […]
General Structure Information 3ope ASH1L structural basis of auto-inhibitory mechanism of histone methyltransferase 2.9Å AUTH S.AN,K.J.YEO,Y.H.JEON,J.SONGTITL CRYSTAL STRUCTURE OF THE HUMAN HISTONE METHYLTRANSFERASETITL 2 ASH1L CATALYTIC DOMAIN AND ITS IMPLICATIONS FOR THETITL 3 REGULATORY MECHANISMREF J.BIOL.CHEM. V. 286 8369 2011REFN ISSN 0021-9258PMID 21239497DOI 10.1074/JBC.M110.203380 Variant Set Distributions Mapped Variants
General Structure Information 1few DIABLO crystal structure of smac/diablo 2.2Å AUTH J.CHAI,C.DU,J.W.WU,S.KYIN,X.WANG,Y.SHITITL STRUCTURAL AND BIOCHEMICAL BASIS OF APOPTOTIC ACTIVATION BYTITL 2 SMAC/DIABLO.REF NATURE V. 406 855 2000REFN ISSN 0028-0836PMID 10972280DOI 10.1038/35022514 Variant Set Distributions Mapped Variants
General Structure Information 4edj GORASP2 crystal structure of the grasp55 grasp domain with a phosphomimetic mutation (s189d) 1.9Å AUTH S.T.TRUSCHEL,M.ZHANG,C.BACHERT,M.R.MACBETH,A.D.LINSTEDTTITL ALLOSTERIC REGULATION OF GRASP PROTEIN-DEPENDENT GOLGITITL 2 MEMBRANE TETHERING BY MITOTIC PHOSPHORYLATION.REF J.BIOL.CHEM. V. 287 19870 2012REFN ISSN 0021-9258PMID 22523075DOI 10.1074/JBC.M111.326256 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1x4w ZFAND3 solution structure of the zf-an1 domain from human hypothetical protein flj13222 -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZF-AN1 DOMAIN FROM HUMANTITL 2 HYPOTHETICAL PROTEIN FLJ13222REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3d8c HIF1AN factor inhibiting hif-1 alpha d201g mutant in complex with zn(ii), alpha-ketoglutarate and hif-1 alpha 19mer 2.1Å AUTH K.S.HEWITSON,S.L.HOLMES,D.EHRISMANN,A.P.HARDY,R.CHOWDHURY,AUTH 2 C.J.SCHOFIELD,M.A.MCDONOUGHTITL EVIDENCE THAT TWO ENZYME-DERIVED HISTIDINE LIGANDS ARETITL 2 SUFFICIENT FOR IRON BINDING AND CATALYSIS BY FACTORTITL 3 INHIBITING HIF (FIH).REF J.BIOL.CHEM. V. 283 25971 2008REFN ISSN 0021-9258PMID 18611856DOI 10.1074/JBC.M804999200 Variant […]
General Structure Information 4jiz MOB1A human mob1-phosphopeptide complex 2.1Å AUTH J.M.ROCK,D.LIM,L.STACH,R.W.OGRODOWICZ,J.M.KECK,M.H.JONES,AUTH 2 C.C.WONG,J.R.YATES,M.WINEY,S.J.SMERDON,M.B.YAFFE,A.AMONTITL ACTIVATION OF THE YEAST HIPPO PATHWAY BYTITL 2 PHOSPHORYLATION-DEPENDENT ASSEMBLY OF SIGNALING COMPLEXES.REF SCIENCE V. 340 871 2013REFN ISSN 0036-8075PMID 23579499DOI 10.1126/SCIENCE.1235822 Variant Set Distributions Mapped Variants
General Structure Information 3dcy C12orf5 crystal structure a tp53-induced glycolysis and apoptosis regulator protein from homo sapiens. 1.75Å AUTH J.G.MCCOY,C.A.BINGMAN,G.E.WESENBERG,AUTH 2 G.N.PHILLIPS JR.TITL CRYSTAL STRUCTURE A TP53-INDUCED GLYCOLYSIS ANDTITL 2 APOPTOSIS REGULATOR PROTEIN FROM HOMO SAPIENS.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2v4u CTPS2 human ctp synthetase 2 – glutaminase domain in complex with 5-oxo-l-norleucine 2.3Å AUTH M.WELIN,M.MOCHE,J.ANDERSSON,C.H.ARROWSMITH,AUTH 2 H.BERGLUND,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,AUTH 4 A.JOHANSSON,I.JOHANSSON,T.KARLBERG,T.KOTENYOVA,AUTH 5 L.LEHTIO,M.E.NILSSON,T.NYMAN,K.OLESEN,C.PERSSON,AUTH 6 J.SAGEMARK,H.SCHUELER,A.G.THORSELL,L.TRESAUGUES,AUTH 7 S.VAN DEN BERG,M.WISNIEWSKA,J.WEIGELT,M.WIKSTROM,AUTH 8 P.NORDLUNDTITL HUMAN CTP SYNTHETASE 2 – GLUTAMINASE DOMAIN INTITL 2 COMPLEX WITH 5-OXO-L-NORLEUCINEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants