Assessment of Structural Intolerance and Durability
General Structure Information 2dkz GAREM solution structure of the sam_pnt-domain of the hypothetical protein loc64762 -1.0Å AUTH A.K.GORONCY,M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SAM_PNT-DOMAIN OF THETITL 2 HYPOTHETICAL PROTEIN LOC64762REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dk6 PARP11 solution structure of wwe domain in poly (adp-ribose) polymerase family, member 11 (parp 11) -1.0Å AUTH F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF WWE DOMAIN IN POLYTITL 2 (ADP-RIBOSE) POLYMERASE FAMILY, MEMBER 11 (PARP 11)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3zqs FANCL human fancl central domain 2.0Å AUTH C.HODSON,A.R.COLE,L.P.LEWIS,J.A.MILES,AUTH 2 A.PURKISS-TREW,H.WALDENTITL STRUCTURAL ANALYSIS OF HUMAN FANCL, THE E3 LIGASETITL 2 IN THE FANCONI ANEMIA PATHWAY.REF J.BIOL.CHEM. V. 286 32628 2011REFN ISSN 0021-9258PMID 21775430DOI 10.1074/JBC.M111.244632 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ai6 PHPT1 solution structure of human phosphohistidine phosphatase 1 -1.0Å AUTH W.GONG,Y.LI,G.CUI,J.HU,H.FANG,C.JIN,B.XIATITL SOLUTION STRUCTURE AND CATALYTIC MECHANISM OFTITL 2 HUMAN PROTEIN HISTIDINE PHOSPHATASE 1.REF BIOCHEM.J. V. 418 337 2009REFN ISSN 0264-6021PMID 18991813DOI 10.1042/BJ20081571 Variant Set Distributions Mapped Variants
General Structure Information 2ee0 PCDH9 solution structures of the ca domain of human protocadherin 9 -1.0Å AUTH M.SATO,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE CA DOMAIN OF HUMANTITL 2 PROTOCADHERIN 9REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4b6l PLK3 discovery of oral polo-like kinase (plk) inhibitors with enhanced selectivity profile using residue targeted drug design 1.9Å AUTH K.BROWN,J.D.CHARRIER,S.DURRANT,M.GRIFFITHS,C.HUDSON,D.KAY,AUTH 2 R.KNEGTEL,M.ODONNELL,F.PIERARD,H.TWIN,P.WEBER,S.YOUNGTITL DISCOVERY OF ORAL POLO-LIKE KINASE (PLK) INHIBITORS WITHTITL 2 ENHANCED SELECTIVITY PROFILE USING RESIDUE TARGETED DRUGTITL 3 DESIGNREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dah UBQLN3 solution structure of the c-terminal uba domain in the human ubiquilin 3 -1.0Å AUTH C.ZHAO,T.KIGAWA,M.SATO,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C-TERMINAL UBA DOMAIN INTITL 2 THE HUMAN UBIQUILIN 3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ed0 ABI2 solution structure of the sh3 domain of abl interactor 2 (abelson interactor 2) -1.0Å AUTH H.ABE,N.TOCHIO,K.MIYAMOTO,K.SAITO,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF ABLTITL 2 INTERACTOR 2 (ABELSON INTERACTOR 2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2nn6 EXOSC5 structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40 3.35Å AUTH Q.LIU,J.C.GREIMANN,C.D.LIMATITL RECONSTITUTION, ACTIVITIES, AND STRUCTURE OF THETITL 2 EUKARYOTIC RNA EXOSOME.REF CELL(CAMBRIDGE,MASS.) V. 127 1223 2006REFN ISSN 0092-8674PMID 17174896DOI 10.1016/J.CELL.2006.10.037 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2nn6 EXOSC4 structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40 3.35Å AUTH Q.LIU,J.C.GREIMANN,C.D.LIMATITL RECONSTITUTION, ACTIVITIES, AND STRUCTURE OF THETITL 2 EUKARYOTIC RNA EXOSOME.REF CELL(CAMBRIDGE,MASS.) V. 127 1223 2006REFN ISSN 0092-8674PMID 17174896DOI 10.1016/J.CELL.2006.10.037 Variant Set Distributions Mapped Variants