Assessment of Structural Intolerance and Durability
General Structure Information 2cok PARP1 solution structure of brct domain of poly(adp-ribose) polymerase-1 -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF BRCT DOMAIN OFTITL 2 POLY(ADP-RIBOSE) POLYMERASE-1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3bch RPSA crystal structure of the human laminin receptor precursor 2.15Å AUTH K.V.JAMIESON,J.WU,S.R.HUBBARD,D.MERUELOTITL CRYSTAL STRUCTURE OF THE HUMAN LAMININ RECEPTORTITL 2 PRECURSOR.REF J.BIOL.CHEM. V. 283 3002 2008REFN ISSN 0021-9258PMID 18063583DOI 10.1074/JBC.C700206200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4dqm RARA revealing a marine natural product as a novel agonist for retinoic acid receptors with a unique binding mode and antitumor activity 2.75Å AUTH S.WANG,Z.WANG,S.LIN,W.ZHENG,R.WANG,S.JIN,J.CHEN,L.JIN,Y.LITITL REVEALING A NATURAL MARINE PRODUCT AS A NOVEL AGONIST FORTITL 2 RETINOIC ACID RECEPTORS WITH A UNIQUE BINDING MODE ANDTITL 3 INHIBITORY EFFECTS ON CANCER CELLS.REF […]
General Structure Information 1z8d PYGM crystal structure of human muscle glycogen phosphorylase a with amp and glucose 2.3Å AUTH C.M.LUKACS,N.G.OIKONOMAKOS,R.L.CROWTHER,L.N.HONG,AUTH 2 R.U.KAMMLOTT,W.LEVIN,S.LI,C.M.LIU,D.LUCAS-MCGADY,AUTH 3 S.PIETRANICO,L.REIKTITL THE CRYSTAL STRUCTURE OF HUMAN MUSCLE GLYCOGEN PHOSPHORYLASETITL 2 A WITH BOUND GLUCOSE AND AMP: AN INTERMEDIATE CONFORMATIONTITL 3 WITH T-STATE AND R-STATE FEATURES.REF PROTEINS V. 63 1123 2006REFN ISSN 0887-3585PMID […]
General Structure Information 2iik ACAA1 crystal structure of human peroxisomal acetyl-coa acyl transferase 1 (acaa1) 2.55Å AUTH E.PAPAGRIGORIOU,C.JOHANSSON,C.SMEE,K.KAVANAGH,A.C.W.PIKE,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.EDWARDS,C.H.ARROWSMITH,O.GILEADI,AUTH 3 F.GORREC,C.UMEANO,F.VON DELFT,U.OPPERMANN,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF HUMAN PEROXISOMAL ACETYL-COA ACYLTITL 2 TRANSFERASE 1 (ACAA1)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1ni6 HMOX1 comparisions of the heme-free and-bound crystal structures of human heme oxygenase-1 2.1Å AUTH L.LAD,D.J.SCHULLER,H.SHIMIZU,J.FRIEDMAN,H.LI,AUTH 2 P.R.ORTIZ DE MONTELLANO,T.L.POULOSTITL COMPARISON OF THE HEME-FREE AND -BOUND CRYSTALTITL 2 STRUCTURES OF HUMAN HEME OXYGENASE-1REF J.BIOL.CHEM. V. 278 7834 2003REFN ISSN 0021-9258PMID 12500973DOI 10.1074/JBC.M211450200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2l86 IAPP solution nmr structure of human amylin in sds micelles at ph 7.3 -1.0Å AUTH R.P.NANGA,J.R.BRENDER,S.VIVEKANANDAN,A.RAMAMOORTHYTITL STRUCTURE AND MEMBRANE ORIENTATION OF IAPP IN ITS NATIVELYTITL 2 AMIDATED FORM AT PHYSIOLOGICAL PH IN A MEMBRANE ENVIRONMENT.REF BIOCHIM.BIOPHYS.ACTA V.1808 2337 2011REFN ISSN 0006-3002PMID 21723249DOI 10.1016/J.BBAMEM.2011.06.012 Variant Set Distributions Mapped Variants
General Structure Information 1hve ANXA5 structural and electrophysiological analysis of annexin v mutants. mutagenesis of human annexin v, an in vitro voltage-gated calcium channel, provides information about the structural features of the ion pathway, the voltage sensor and the ion selectivity filter 2.3Å AUTH A.BURGER,D.VOGES,P.DEMANGE,C.R.PEREZ,R.HUBER,AUTH 2 R.BERENDESTITL STRUCTURAL AND ELECTROPHYSIOLOGICAL ANALYSIS OFTITL 2 ANNEXIN V […]
General Structure Information 2c01 RNASE2 crystal structures of eosinophil-derived neurotoxin in complex with the inhibitors 5-atp, ap3a, ap4a and ap5a 1.24Å AUTH M.D.BAKER,D.E.HOLLOWAY,G.J.SWAMINATHAN,K.R.ACHARYATITL CRYSTAL STRUCTURES OF EOSINOPHIL-DERIVEDTITL 2 NEUROTOXIN (EDN) IN COMPLEX WITH THE INHIBITORSTITL 3 5- ATP, AP(3)A, AP(4)A, AND AP(5)A.REF BIOCHEMISTRY V. 45 416 2006REFN ISSN 0006-2960PMID 16401072DOI 10.1021/BI0518592 Variant Set Distributions Mapped […]
General Structure Information 3g0f KIT kit kinase domain mutant d816h in complex with sunitinib 2.6Å AUTH K.S.GAJIWALA,J.C.WU,J.CHRISTENSEN,G.D.DESHMUKH,AUTH 2 W.DIEHL,J.P.DINITTO,J.M.ENGLISH,M.J.GREIG,Y.A.HE,AUTH 3 S.L.JACQUES,E.A.LUNNEY,M.MCTIGUE,D.MOLINA,AUTH 4 T.QUENZER,P.A.WELLS,X.YU,Y.ZHANG,A.ZOU,M.R.EMMETT,AUTH 5 A.G.MARSHALL,H.M.ZHANG,G.D.DEMETRITITL KIT KINASE MUTANTS SHOW UNIQUE MECHANISMS OF DRUGTITL 2 RESISTANCE TO IMATINIB AND SUNITINIB INTITL 3 GASTROINTESTINAL STROMAL TUMOR PATIENTS.REF PROC.NATL.ACAD.SCI.USA V. 106 1542 2009REFN ISSN 0027-8424PMID 19164557DOI 10.1073/PNAS.0812413106 Variant […]