Assessment of Structural Intolerance and Durability
General Structure Information 1k95 GCA crystal structure of des(1-52)grancalcin with bound calcium 1.9Å AUTH J.JIA,N.BORREGAARD,K.LOLLIKE,M.CYGLERTITL STRUCTURE OF CA(2+)-LOADED HUMAN GRANCALCIN.REF ACTA CRYSTALLOGR.,SECT.D V. 57 1843 2001REFN ISSN 0907-4449PMID 11717497DOI 10.1107/S0907444901016511 Variant Set Distributions Mapped Variants
General Structure Information 3rgh FLNA structure of filamin a immunoglobulin-like repeat 10 from homo sapiens 2.44Å AUTH R.C.PAGE,J.G.CLARK,S.MISRATITL STRUCTURE OF FILAMIN A IMMUNOGLOBULIN-LIKE REPEAT 10 FROMTITL 2 HOMO SAPIENS.REF ACTA CRYSTALLOGR.,SECT.F V. 67 871 2011REFN ESSN 1744-3091PMID 21821884DOI 10.1107/S1744309111024249 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3v5w ADRBK1 human g protein-coupled receptor kinase 2 in complex with soluble gbetagamma subunits and paroxetine 2.07Å AUTH D.M.THAL,K.T.HOMAN,J.CHEN,E.K.WU,P.M.HINKLE,Z.M.HUANG,AUTH 2 J.K.CHUPRUN,J.SONG,E.GAO,J.Y.CHEUNG,L.A.SKLAR,W.J.KOCH,AUTH 3 J.J.TESMERTITL PAROXETINE IS A DIRECT INHIBITOR OF G PROTEIN-COUPLEDTITL 2 RECEPTOR KINASE 2 AND INCREASES MYOCARDIAL CONTRACTILITY.REF ACS CHEM.BIOL. V. 7 1830 2012REFN ISSN 1554-8929PMID 22882301DOI 10.1021/CB3003013 Variant Set Distributions […]
General Structure Information 1el0 CCL1 solution structure of the human cc chemokine, i-309 -1.0Å AUTH D.W.KEIZER,M.P.CRUMP,T.W.LEE,C.M.SLUPSKY,AUTH 2 I.CLARK-LEWIS,B.D.SYKESTITL HUMAN CC CHEMOKINE I-309, STRUCTURAL CONSEQUENCESTITL 2 OF THE ADDITIONAL DISULFIDE BOND.REF BIOCHEMISTRY V. 39 6053 2000REFN ISSN 0006-2960PMID 10821677DOI 10.1021/BI000089L Variant Set Distributions Mapped Variants
General Structure Information 2k4t VDAC1 solution structure of human vdac-1 in ldao micelles -1.0Å AUTH S.HILLER,R.G.GARCES,T.J.MALIA,V.Y.OREKHOV,AUTH 2 M.COLOMBINI,G.WAGNERTITL SOLUTION STRUCTURE OF THE INTEGRAL HUMAN MEMBRANETITL 2 PROTEIN VDAC-1 IN DETERGENT MICELLES.REF SCIENCE V. 321 1206 2008REFN ISSN 0036-8075PMID 18755977DOI 10.1126/SCIENCE.1161302 Variant Set Distributions Mapped Variants
General Structure Information 2e9w KITLG crystal structure of the extracellular domain of kit in complex with stem cell factor (scf) 3.5Å AUTH S.YUZAWA,Y.OPATOWSKY,Z.ZHANG,V.MANDIYAN,I.LAX,J.SCHLESSINGERTITL STRUCTURAL BASIS FOR ACTIVATION OF THE RECEPTOR TYROSINETITL 2 KINASE KIT BY STEM CELL FACTORREF CELL(CAMBRIDGE,MASS.) V. 130 323 2007REFN ISSN 0092-8674PMID 17662946DOI 10.1016/J.CELL.2007.05.055 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2jjd PTPRE protein tyrosine phosphatase, receptor type, e isoform 3.2Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.F.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lgw DNAJB2 solution structure of the j domain of hsj1a -1.0Å AUTH X.GAO,C.ZHOU,Z.ZHOU,M.WU,C.CAO,H.HUTITL THE C-TERMINAL HELICES OF HSP70 ARE ESSENTIAL FOR HSJ1ATITL 2 J-DOMAIN BINDING AND ATPASE ACTIVATIONREF J.BIOL.CHEM. 2012REFN ESSN 1083-351XDOI 10.1074/JBC.M111.294728 Variant Set Distributions Mapped Variants
General Structure Information 2e8n EPHA2 solution structure of the c-terminal sam-domain of ephaa2: ephrin type-a receptor 2 precursor (ec 2.7.10.1) -1.0Å AUTH A.K.GORONCY,M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C-TERMINAL SAM-DOMAIN OFTITL 2 EPHAA2: EPHRIN TYPE-A RECEPTOR 2 PRECURSOR (ECTITL 3 2.7.10.1)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1ucv EPHA8 sterile alpha motif (sam) domain of ephrin type-a receptor 8 -1.0Å AUTH A.GORONCY,T.KIGAWA,S.KOSHIBA,N.KOBAYASHI,N.TOCHIO,AUTH 2 M.INOUE,S.YOKOYAMATITL NMR STRUCTURE OF STERILE ALPHA MOTIF (SAM) DOMAINTITL 2 OF EPHRIN TYPE-A RECEPTOR 8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants