Assessment of Structural Intolerance and Durability
General Structure Information 1cf7 TFDP2 structural basis of dna recognition by the heterodimeric cell cycle transcription factor e2f-dp 2.6Å AUTH N.ZHENG,E.FRAENKEL,C.O.PABO,N.P.PAVLETICHTITL STRUCTURAL BASIS OF DNA RECOGNITION BY THETITL 2 HETERODIMERIC CELL CYCLE TRANSCRIPTION FACTORTITL 3 E2F-DP.REF GENES DEV. V. 13 666 1999REFN ISSN 0890-9369PMID 10090723 Variant Set Distributions Mapped Variants
General Structure Information 2oeh ARID5B determination of the three-dimensional structure of the mrf2-dna complex using paramagnetic spin labeling -1.0Å AUTH S.CAI,L.ZHU,Z.ZHANG,Y.CHENTITL DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURETITL 2 OF THE MRF2-DNA COMPLEX USING PARAMAGNETIC SPINTITL 3 LABELING.REF BIOCHEMISTRY V. 46 4943 2007REFN ISSN 0006-2960PMID 17407261DOI 10.1021/BI061738H Variant Set Distributions Mapped Variants
General Structure Information 4iz5 PEA15 structure of the complex between erk2 phosphomimetic mutant and pea-15 3.19Å AUTH P.D.MACE,Y.WALLEZ,M.F.EGGER,M.K.DOBACZEWSKA,H.ROBINSON,AUTH 2 E.B.PASQUALE,S.J.RIEDLTITL STRUCTURE OF ERK2 BOUND TO PEA-15 REVEALS A MECHANISM FORTITL 2 RAPID RELEASE OF ACTIVATED MAPK.REF NAT COMMUN V. 4 1681 2013REFN ESSN 2041-1723PMID 23575685DOI 10.1038/NCOMMS2687 Variant Set Distributions Mapped Variants
General Structure Information 4f7b SCARB2 structure of the lysosomal domain of limp-2 3.0Å AUTH D.NECULAI,M.SCHWAKE,M.RAVICHANDRAN,F.ZUNKE,R.F.COLLINS,AUTH 2 J.PETERS,M.NECULAI,J.PLUMB,P.LOPPNAU,J.C.PIZARRO,A.SEITOVA,AUTH 3 W.S.TRIMBLE,P.SAFTIG,S.GRINSTEIN,S.DHE-PAGANONTITL STRUCTURE OF LIMP-2 PROVIDES FUNCTIONAL INSIGHTS WITHTITL 2 IMPLICATIONS FOR SR-BI AND CD36.REF NATURE V. 504 172 2013REFN ISSN 0028-0836PMID 24162852DOI 10.1038/NATURE12684 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2ux0 CAMK2G structure of the oligomerisation domain of calcium- calmodulin dependent protein kinase ii gamma 2.46Å AUTH P.RELLOS,A.C.W.PIKE,F.H.NIESEN,E.SALAH,W.H.LEE,AUTH 2 F.VON DELFT,S.KNAPPTITL STRUCTURE OF THE CAMKIIDELTA/CALMODULIN COMPLEXTITL 2 REVEALS THE MOLECULAR MECHANISM OF CAMKII KINASETITL 3 ACTIVATION.REF PLOS BIOL. V. 8 426 2010REFN ISSN 1544-9173PMID 20668654DOI 10.1371/JOURNAL.PBIO.1000426 Variant Set Distributions Mapped Variants
General Structure Information 4i6x PDIA5 crystal structure of non-catalyic domain of protein disulfide isomerase-related (pdir) protein 1.5Å AUTH R.VINAIK,G.KOZLOV,K.GEHRINGTITL STRUCTURE OF THE NON-CATALYTIC DOMAIN OF THE PROTEINTITL 2 DISULFIDE ISOMERASE-RELATED PROTEIN (PDIR) REVEALS FUNCTIONTITL 3 IN PROTEIN BINDING.REF PLOS ONE V. 8 62021 2013REFN ESSN 1932-6203PMID 23614004DOI 10.1371/JOURNAL.PONE.0062021 Variant Set Distributions Mapped Variants
General Structure Information 2k1m MYBPC3 3d nmr structure of domain cc0 of cardiac myosin binding protein c (mybpc) -1.0Å AUTH J.RATTI,M.GAUTEL,M.PFUHLTITL 3D NMR STRUCTURE OF DOMAIN CC0 OF CARDIAC MYOSINTITL 2 BINDING PROTEIN C (MYBPC)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2vn9 CAMK2D crystal structure of human calcium calmodulin dependent protein kinase ii delta isoform 1, camkd 2.3Å AUTH P.RELLOS,A.C.W.PIKE,F.H.NIESEN,E.SALAH,W.H.LEE,AUTH 2 F.VON DELFT,S.KNAPPTITL STRUCTURE OF THE CAMKIIDELTA/CALMODULIN COMPLEXTITL 2 REVEALS THE MOLECULAR MECHANISM OF CAMKII KINASETITL 3 ACTIVATION.REF PLOS BIOL. V. 8 426 2010REFN ISSN 1544-9173PMID 20668654DOI 10.1371/JOURNAL.PBIO.1000426 Variant Set Distributions Mapped Variants
General Structure Information 4cnc TPBG crystal structure of human 5t4 (wnt-activated inhibitory factor 1, trophoblast glycoprotein) 1.77Å AUTH Y.ZHAO,T.MALINAUSKAS,K.HARLOS,E.Y.JONESTITL STRUCTURAL INSIGHTS INTO THE INHIBITION OF WNT SIGNALING BYTITL 2 CANCER ANTIGEN 5T4/WNT-ACTIVATED INHIBITORY FACTOR 1.REF STRUCTURE V. 22 612 2014REFN ISSN 0969-2126PMID 24582434DOI 10.1016/J.STR.2014.01.009 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3oxq CACNA1C crystal structure of ca2+/cam-cav1.2 pre-iq/iq domain complex 2.55Å AUTH E.Y.KIM,C.H.RUMPF,F.VAN PETEGEM,R.J.ARANT,F.FINDEISEN,AUTH 2 E.S.COOLEY,E.Y.ISACOFF,D.L.MINORTITL MULTIPLE C-TERMINAL TAIL CA(2+)/CAMS REGULATE CA(V)1.2TITL 2 FUNCTION BUT DO NOT MEDIATE CHANNEL DIMERIZATION.REF EMBO J. V. 29 3924 2010REFN ISSN 0261-4189PMID 20953164DOI 10.1038/EMBOJ.2010.260 Variant Set Distributions Mapped Variants