General Structure Information 3lcy TTN titin ig tandem domains a164-a165 2.5Å AUTH Q.CHEN,M.WILMANNSTITL STRUCTURAL INVESTIGATION OF THE TITIN A-BAND TANDEM IGTITL 2 DOMAINS A164-A165REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
Assessment of Structural Intolerance and Durability
General Structure Information 3lcy TTN titin ig tandem domains a164-a165 2.5Å AUTH Q.CHEN,M.WILMANNSTITL STRUCTURAL INVESTIGATION OF THE TITIN A-BAND TANDEM IGTITL 2 DOMAINS A164-A165REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1tki TTN autoinhibited serine kinase domain of the giant muscle protein titin 2.0Å AUTH O.MAYANS,P.F.VAN DER VEN,M.WILM,A.MUES,P.YOUNG,AUTH 2 D.O.FURST,M.WILMANNS,M.GAUTELTITL STRUCTURAL BASIS FOR ACTIVATION OF THE TITINTITL 2 KINASE DOMAIN DURING MYOFIBRILLOGENESIS.REF NATURE V. 395 863 1998REFN ISSN 0028-0836PMID 9804419DOI 10.1038/27603 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2nzi TTN crystal structure of domains a168-a170 from titin 2.9Å AUTH M.MROSEK,D.LABEIT,S.WITT,H.HEERKLOTZ,AUTH 2 E.VON CASTELMUR,S.LABEIT,O.MAYANSTITL MOLECULAR DETERMINANTS FOR THE RECRUITMENT OF THETITL 2 UBIQUITIN-LIGASE MURF-1 ONTO M-LINE TITIN.REF FASEB J. V. 21 1383 2007REFN ISSN 0892-6638PMID 17215480DOI 10.1096/FJ.06-7644COM Variant Set Distributions Mapped Variants
General Structure Information 3ueo TOPBP1 crystal structure of topbp1 brct4/5 domains in complex with a phospho- peptide 2.6Å AUTH C.C.LEUNG,L.SUN,Z.GONG,M.BURKAT,R.EDWARDS,M.ASSMUS,J.CHEN,AUTH 2 J.N.GLOVERTITL STRUCTURAL INSIGHTS INTO RECOGNITION OF MDC1 BY TOPBP1 INTITL 2 DNA REPLICATION CHECKPOINT CONTROL.REF STRUCTURE V. 21 1450 2013REFN ISSN 0969-2126PMID 23891287DOI 10.1016/J.STR.2013.06.015 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2ysx INPP5D solution structure of the human ship sh2 domain -1.0Å AUTH T.KASAI,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE HUMAN SHIP SH2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3sde PSPC1 crystal structure of a paraspeckle-protein heterodimer, pspc1/nono 1.9Å AUTH D.M.PASSON,M.LEE,O.RACKHAM,W.A.STANLEY,A.SADOWSKA,AUTH 2 A.FILIPOVSKA,A.H.FOX,C.S.BONDTITL STRUCTURE OF THE HETERODIMER OF HUMAN NONO AND PARASPECKLETITL 2 PROTEIN COMPONENT 1 AND ANALYSIS OF ITS ROLE IN SUBNUCLEARTITL 3 BODY FORMATION.REF PROC.NATL.ACAD.SCI.USA V. 109 4846 2012REFN ISSN 0027-8424PMID 22416126DOI 10.1073/PNAS.1120792109 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3tug ITCH crystal structure of the hect domain of itch e3 ubiquitin ligase 2.27Å AUTH E.DOBROVETSKY,A.DONG,S.XUE,C.BUTLER,A.WERNIMONT,J.R.WALKER,AUTH 2 W.TEMPEL,S.DHE-PAGANON,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,AUTH 3 Y.TONGTITL CRYSTAL STRUCTURE OF THE HECT DOMAIN OF ITCH E3 UBIQUITINTITL 2 LIGASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3o3i PIWIL1 crystal structure of human hiwi1 paz domain (residues 277-399) in complex with 14-mer rna (12-bp + 2-nt overhang) containing 2-oh at its 3-end 2.8Å AUTH Y.TIAN,D.K.SIMANSHU,J.B.MA,D.J.PATELTITL INAUGURAL ARTICLE: STRUCTURAL BASIS FOR PIRNATITL 2 2-O-METHYLATED 3-END RECOGNITION BY PIWI PAZTITL 3 (PIWI/ARGONAUTE/ZWILLE) DOMAINS.REF PROC.NATL.ACAD.SCI.USA V. 108 903 2011REFN ISSN 0027-8424PMID 21193640DOI […]
General Structure Information 3qp3 TTN crystal structure of titin domain m4, tetragonal form 2.0Å AUTH F.SAUER,A.KOLODZIEJCZYK,M.WILMANNSTITL CRYSTAL STRUCTURE OF TITIN DOMAIN M4, TETRAGONAL FORMREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3rjw EHMT2 crystal structure of histone lysine methyltransferase g9a with an inhibitor 2.56Å AUTH M.VEDADI,D.BARSYTE-LOVEJOY,F.LIU,S.RIVAL-GERVIER,AUTH 2 A.ALLALI-HASSANI,V.LABRIE,T.J.WIGLE,P.A.DIMAGGIO,G.A.WASNEY,AUTH 3 A.SIARHEYEVA,A.DONG,W.TEMPEL,S.C.WANG,X.CHEN,I.CHAU,AUTH 4 T.J.MANGANO,X.P.HUANG,C.D.SIMPSON,S.G.PATTENDEN,J.L.NORRIS,AUTH 5 D.B.KIREEV,A.TRIPATHY,A.EDWARDS,B.L.ROTH,W.P.JANZEN,AUTH 6 B.A.GARCIA,A.PETRONIS,J.ELLIS,P.J.BROWN,S.V.FRYE,AUTH 7 C.H.ARROWSMITH,J.JINTITL A CHEMICAL PROBE SELECTIVELY INHIBITS G9A AND GLPTITL 2 METHYLTRANSFERASE ACTIVITY IN CELLS.REF NAT.CHEM.BIOL. V. 7 566 2011REFN ISSN 1552-4450PMID 21743462DOI 10.1038/NCHEMBIO.599 Variant Set Distributions […]