Assessment of Structural Intolerance and Durability
General Structure Information 2f1z USP7 crystal structure of hausp 3.2Å AUTH M.HU,L.GU,M.LI,P.D.JEFFREY,W.GU,Y.SHITITL STRUCTURAL BASIS OF COMPETITIVE RECOGNITION OF P53TITL 2 AND MDM2 BY HAUSP/USP7: IMPLICATIONS FOR THETITL 3 REGULATION OF THE P53-MDM2 PATHWAY.REF PLOS BIOL. V. 4 E27 2006REFN ISSN 1544-9173PMID 16402859DOI 10.1371/JOURNAL.PBIO.0040027 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1ya0 SMG7 crystal structure of the n-terminal domain of human smg7 2.55Å AUTH N.FUKUHARA,J.EBERT,L.UNTERHOLZNER,D.LINDNER,AUTH 2 E.IZAURRALDE,E.CONTITITL SMG7 IS A 14-3-3-LIKE ADAPTOR IN THETITL 2 NONSENSE-MEDIATED MRNA DECAY PATHWAY.REF MOL.CELL V. 17 537 2005REFN ISSN 1097-2765PMID 15721257DOI 10.1016/J.MOLCEL.2005.01.010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1rj7 EDA crystal structure of eda-a1 2.3Å AUTH S.G.HYMOWITZ,D.M.COMPAAN,M.YAN,H.J.WALLWEBER,V.M.DIXIT,AUTH 2 M.A.STAROVASNIK,A.M.DE VOSTITL THE CRYSTAL STRUCTURES OF EDA-A1 AND EDA-A2: SPLICE VARIANTSTITL 2 WITH DISTINCT RECEPTOR SPECIFICITY.REF STRUCTURE V. 11 1513 2003REFN ISSN 0969-2126PMID 14656435DOI 10.1016/J.STR.2003.11.009 Variant Set Distributions Mapped Variants
General Structure Information 3nbh RMI2 crystal structure of human rmi1c-rmi2 complex 2.0Å AUTH F.WANG,Y.YANG,T.R.SINGH,V.BUSYGINA,R.GUO,K.WAN,W.WANG,AUTH 2 P.SUNG,A.R.MEETEI,M.LEITITL CRYSTAL STRUCTURES OF RMI1 AND RMI2, TWO OB-FOLD REGULATORYTITL 2 SUBUNITS OF THE BLM COMPLEX.REF STRUCTURE V. 18 1159 2010REFN ISSN 0969-2126PMID 20826342DOI 10.1016/J.STR.2010.06.008 Variant Set Distributions Mapped Variants
General Structure Information 4is7 CASKIN2 crystal structure of the caskin2 sam domain tandem 2.75Å AUTH KWAN J.J.,E.SMIRNOVA,V.SARIDAKIS,DONALDSON L.W.TITL CRYSTAL STRUCTURE OF THE CASKIN2 SAM DOMAIN TANDEMREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2xoc CHFR c-terminal cysteine-rich domain of human chfr bound to madpr 1.89Å AUTH J.OBEROI,M.W.RICHARDS,S.CRUMPLER,N.BROWN,J.BLAGG,AUTH 2 R.BAYLISSTITL STRUCTURAL BASIS OF POLY(ADP-RIBOSE) RECOGNITIONTITL 2 BY THE MULTIZINC BINDING DOMAIN OF CHECKPOINT WITHTITL 3 FORKHEAD-ASSOCIATED AND RING DOMAINS (CHFR).REF J.BIOL.CHEM. V. 285 39348 2010REFN ISSN 0021-9258PMID 20880844DOI 10.1074/JBC.M110.159855 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3whd CLEC4D c-type lectin, human mcl 2.29Å AUTH A.FURUKAWA,J.KAMISHIKIRYO,D.MORI,K.TOYONAGA,Y.OKABE,A.TOJI,AUTH 2 R.KANDA,Y.MIYAKE,T.OSE,S.YAMASAKI,K.MAENAKATITL STRUCTURAL ANALYSIS FOR GLYCOLIPID RECOGNITION BY THE C-TYPETITL 2 LECTINS MINCLE AND MCLREF PROC.NATL.ACAD.SCI.USA V. 110 17438 2013REFN ISSN 0027-8424PMID 24101491DOI 10.1073/PNAS.1312649110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ly1 HDAC2 structure of human hdac2 in complex with inhibitor 4-(acetylamino)-n- [2-amino-5-(thiophen-2-yl)phenyl]benzamide 1.57Å AUTH B.E.LAUFFER,R.MINTZER,R.FONG,S.MUKUND,C.TAM,I.ZILBERLEYB,AUTH 2 B.FLICKE,A.RITSCHER,G.FEDOROWICZ,R.VALLERO,D.F.ORTWINE,AUTH 3 J.GUNZNER,Z.MODRUSAN,L.NEUMANN,C.M.KOTH,P.J.LUPARDUS,AUTH 4 J.S.KAMINKER,C.E.HEISE,P.STEINERTITL HISTONE DEACETYLASE (HDAC) INHIBITOR KINETIC RATE CONSTANTSTITL 2 CORRELATE WITH CELLULAR HISTONE ACETYLATION BUT NOTTITL 3 TRANSCRIPTION AND CELL VIABILITY.REF J.BIOL.CHEM. V. 288 26926 2013REFN ISSN 0021-9258PMID 23897821DOI 10.1074/JBC.M113.490706 Variant Set […]
General Structure Information 2rc4 KAT6A crystal structure of the hat domain of the human moz protein 3.0Å AUTH M.A.HOLBERT,T.SIKORSKI,J.CARTEN,D.SNOWFLACK,S.HODAWADEKAR,AUTH 2 R.MARMORSTEINTITL THE HUMAN MONOCYTIC LEUKEMIA ZINC FINGER HISTONETITL 2 ACETYLTRANSFERASE DOMAIN CONTAINS DNA-BINDING ACTIVITYTITL 3 IMPLICATED IN CHROMATIN TARGETING.REF J.BIOL.CHEM. V. 282 36603 2007REFN ISSN 0021-9258PMID 17925393DOI 10.1074/JBC.M705812200 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1wwv CNKSR1 solution structure of the sam domain of human connector enhancer of ksr-like protein cnk1 -1.0Å AUTH A.GORONCY,T.KIGAWA,S.KOSHIBA,N.KOBAYASHI,N.TOCHIO,AUTH 2 M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SAM DOMAIN OF HUMANTITL 2 CONNECTOR ENHANCER OF KSR-LIKE PROTEIN CNK1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants