Assessment of Structural Intolerance and Durability
General Structure Information 3dxc APBB1 crystal structure of the intracellular domain of human app in complex with fe65-ptb2 2.1Å AUTH J.RADZIMANOWSKI,B.SIMON,M.SATTLER,K.BEYREUTHER,AUTH 2 I.SINNING,K.WILDTITL STRUCTURE OF THE INTRACELLULAR DOMAIN OF THETITL 2 AMYLOID PRECURSOR PROTEIN IN COMPLEX WITHTITL 3 FE65-PTB2.REF EMBO REP. V. 9 1134 2008REFN ISSN 1469-221XPMID 18833287DOI 10.1038/EMBOR.2008.188 Variant Set Distributions Mapped Variants
General Structure Information 2p6v TAF4 structure of tafh domain of the human taf4 subunit of tfiid 2.0Å AUTH X.WANG,D.M.TRUCKSES,S.TAKADA,T.MATSUMURA,N.TANESE,AUTH 2 R.H.JACOBSONTITL CONSERVED REGION I OF HUMAN COACTIVATOR TAF4 BINDSTITL 2 TO A SHORT HYDROPHOBIC MOTIF PRESENT INTITL 3 TRANSCRIPTIONAL REGULATORS.REF PROC.NATL.ACAD.SCI.USA V. 104 7839 2007REFN ISSN 0027-8424PMID 17483474DOI 10.1073/PNAS.0608570104 Variant Set Distributions Mapped Variants
General Structure Information 3ukm KCNK1 crystal structure of the human two pore domain potassium ion channel k2p1 (twik-1) 3.4Å AUTH A.N.MILLER,S.B.LONGTITL CRYSTAL STRUCTURE OF THE HUMAN TWO-PORE DOMAIN POTASSIUMTITL 2 CHANNEL K2P1.REF SCIENCE V. 335 432 2012REFN ISSN 0036-8075PMID 22282804DOI 10.1126/SCIENCE.1213274 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1g55 TRDMT1 structure of human dnmt2, an enigmatic dna methyltransferase homologue 1.8Å AUTH A.DONG,J.A.YODER,X.ZHANG,L.ZHOU,T.H.BESTOR,X.CHENGTITL STRUCTURE OF HUMAN DNMT2, AN ENIGMATIC DNA METHYLTRANSFERASETITL 2 HOMOLOG THAT DISPLAYS DENATURANT-RESISTANT BINDING TO DNA.REF NUCLEIC ACIDS RES. V. 29 439 2001REFN ISSN 0305-1048PMID 11139614DOI 10.1093/NAR/29.2.439 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3mdy BMPR1B crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1b (bmpr1b) in complex with fkbp12 and ldn- 193189 2.05Å AUTH A.CHAIKUAD,C.SANVITALE,P.MAHAJAN,N.DAGA,C.COOPER,T.KROJER,AUTH 2 I.ALFANO,S.KNAPP,F.VON DELFT,J.WEIGELT,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,C.BOUNTRA,A.BULLOCK,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE BONETITL 2 MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B (BMPR1B) IN […]
General Structure Information 4e3c IKBKB x-ray crystal structure of human ikk2 in an active conformation 3.98Å AUTH S.POLLEY,D.B.HUANG,A.V.HAUENSTEIN,A.J.FUSCO,X.ZHONG,D.VU,AUTH 2 A.HOFFMANN,I.V.VERMA,G.GHOSH,T.HUAFORDTITL X-RAY CRYSTAL STRUCTURE OF HUMAN IKK2 IN AN ACTIVETITL 2 CONFORMATIONREF PLOS.BIOL. 2013REFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2gto FYB oxidized form of adap hsh3-n -1.0Å AUTH J.ZIMMERMANN,R.KUHNE,M.SYLVESTER,C.FREUNDTITL REDOX-REGULATED CONFORMATIONAL CHANGES IN AN SH3TITL 2 DOMAINREF BIOCHEMISTRY V. 46 6971 2007REFN ISSN 0006-2960PMID 17511475DOI 10.1021/BI700437R Variant Set Distributions Mapped Variants
General Structure Information 2czh IMPA2 crystal structure of human myo-inositol monophosphatase 2 (impa2) with phosphate ion (orthorhombic form) 2.7Å AUTH R.ARAI,K.ITO,T.OHNISHI,H.OHBA,R.AKASAKA,Y.BESSHO,AUTH 2 K.HANAWA-SUETSUGU,T.YOSHIKAWA,M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF HUMAN MYO-INOSITOLTITL 2 MONOPHOSPHATASE 2, THE PRODUCT OF THE PUTATIVETITL 3 SUSCEPTIBILITY GENE FOR BIPOLAR DISORDER,TITL 4 SCHIZOPHRENIA, AND FEBRILE SEIZURESREF PROTEINS V. 67 732 2007REFN ISSN 0887-3585PMID 17340635DOI […]
General Structure Information 1gum GSTA4 human glutathione transferase a4-4 without ligands 3.0Å AUTH C.M.BRUNS,I.HUBATSCH,M.RIDDERSTROM,B.MANNERVIK,AUTH 2 J.A.TAINERTITL HUMAN GLUTATHIONE TRANSFERASE A4-4 CRYSTALTITL 2 STRUCTURES AND MUTAGENESIS REVEAL THE BASIS OFTITL 3 HIGH CATALYTIC EFFICIENCY WITH TOXIC LIPIDTITL 4 PEROXIDATION PRODUCTSREF J.MOL.BIOL. V. 288 427 1999REFN ISSN 0022-2836PMID 10329152DOI 10.1006/JMBI.1999.2697 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2q5e CTDSP2 crystal structure of human carboxy-terminal domain rna polymerase ii polypeptide a small phosphatase 2 2.51Å AUTH S.C.ALMO,J.B.BONANNO,J.M.SAUDER,S.EMTAGE,AUTH 2 T.P.DILORENZO,V.MALASHKEVICH,S.R.WASSERMAN,AUTH 3 S.SWAMINATHAN,S.ESWARAMOORTHY,R.AGARWAL,D.KUMARAN,AUTH 4 M.MADEGOWDA,S.RAGUMANI,Y.PATSKOVSKY,J.ALVARADO,AUTH 5 U.A.RAMAGOPAL,J.FABER-BARATA,M.R.CHANCE,A.SALI,AUTH 6 A.FISER,Z.Y.ZHANG,D.S.LAWRENCE,S.K.BURLEYTITL STRUCTURAL GENOMICS OF PROTEIN PHOSPHATASES.REF J.STRUCT.FUNCT.GENOM. V. 8 121 2007REFN ISSN 1345-711XPMID 18058037DOI 10.1007/S10969-007-9036-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]