Assessment of Structural Intolerance and Durability
General Structure Information 2aze RB1 structure of the rb c-terminal domain bound to an e2f1-dp1 heterodimer 2.55Å AUTH S.M.RUBIN,A.L.GALL,N.ZHENG,N.P.PAVLETICHTITL STRUCTURE OF THE RB C-TERMINAL DOMAIN BOUND TOTITL 2 E2F1-DP1: A MECHANISM FOR PHOSPHORYLATION-INDUCEDTITL 3 E2F RELEASE.REF CELL(CAMBRIDGE,MASS.) V. 123 1093 2005REFN ISSN 0092-8674PMID 16360038DOI 10.1016/J.CELL.2005.09.044 Variant Set Distributions Mapped Variants
General Structure Information 3tf2 EIF4E crystal structure of the cap free human translation initiation factor eif4e 2.1Å AUTH N.SIDDIQUI,W.TEMPEL,L.NEDYALKOVA,L.VOLPON,A.K.WERNIMONT,AUTH 2 M.J.OSBORNE,H.W.PARK,K.L.BORDENTITL STRUCTURAL INSIGHTS INTO THE ALLOSTERIC EFFECTS OF 4EBP1 ONTITL 2 THE EUKARYOTIC TRANSLATION INITIATION FACTOR EIF4E.REF J.MOL.BIOL. V. 415 781 2012REFN ISSN 0022-2836PMID 22178476DOI 10.1016/J.JMB.2011.12.002 Variant Set Distributions Mapped Variants
General Structure Information 4dm9 UCHL1 the crystal structure of ubiquitin carboxy-terminal hydrolase l1 (uchl1) bound to a tripeptide fluoromethyl ketone z-vae(ome)-fmk 2.35Å AUTH C.W.DAVIES,J.CHANEY,G.KORBEL,D.RINGE,G.A.PETSKO,H.PLOEGH,AUTH 2 C.DASTITL THE CO-CRYSTAL STRUCTURE OF UBIQUITIN CARBOXY-TERMINALTITL 2 HYDROLASE L1 (UCHL1) WITH A TRIPEPTIDE FLUOROMETHYL KETONETITL 3 (Z-VAE(OME)-FMK).REF BIOORG.MED.CHEM.LETT. V. 22 3900 2012REFN ISSN 0960-894XPMID 22617491DOI 10.1016/J.BMCL.2012.04.124 Variant Set Distributions […]
General Structure Information 1pls PLEK solution structure of a pleckstrin homology domain -1.0Å AUTH H.S.YOON,P.J.HAJDUK,A.M.PETROS,E.T.OLEJNICZAK,AUTH 2 R.P.MEADOWS,S.W.FESIKTITL SOLUTION STRUCTURE OF A PLECKSTRIN-HOMOLOGY DOMAIN.REF NATURE V. 369 672 1994REFN ISSN 0028-0836PMID 8208296DOI 10.1038/369672A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1dig MTHFD1 human methylenetetrahydrofolate dehydrogenase / cyclohydrolase complexed with nadp and inhibitor ly374571 2.2Å AUTH A.SCHMIDT,H.WU,R.E.MACKENZIE,V.J.CHEN,J.R.BEWLY,AUTH 2 J.E.RAY,J.E.TOTH,M.CYGLERTITL STRUCTURES OF THREE INHIBITOR COMPLEXES PROVIDETITL 2 INSIGHT INTO THE REACTION MECHANISM OF THE HUMANTITL 3 METHYLENETETRAHYDROFOLATETITL 4 DEHYDROGENASE/CYCLOHYDROLASE.REF BIOCHEMISTRY V. 39 6325 2000REFN ISSN 0006-2960PMID 10828945DOI 10.1021/BI992734Y Variant Set Distributions Mapped Variants
General Structure Information 2fgi FGFR1 crystal structure of the tyrosine kinase domain of fgf receptor 1 in complex with inhibitor pd173074 2.5Å AUTH M.MOHAMMADI,S.FROUM,J.M.HAMBY,M.C.SCHROEDER,AUTH 2 R.L.PANEK,G.H.LU,A.V.ELISEENKOVA,D.GREEN,AUTH 3 J.SCHLESSINGER,S.R.HUBBARDTITL CRYSTAL STRUCTURE OF AN ANGIOGENESIS INHIBITORTITL 2 BOUND TO THE FGF RECEPTOR TYROSINE KINASE DOMAIN.REF EMBO J. V. 17 5896 1998REFN ISSN 0261-4189PMID 9774334DOI 10.1093/EMBOJ/17.20.5896 Variant Set […]
General Structure Information 4glp CD14 the crystal structure of soluble human cd14 reveals a bent solenoid with a hydrophobic amino-terminal pocket. 4.0Å AUTH S.L.KELLEY,T.LUKK,S.K.NAIR,R.I.TAPPINGTITL THE CRYSTAL STRUCTURE OF HUMAN SOLUBLE CD14 REVEALS A BENTTITL 2 SOLENOID WITH A HYDROPHOBIC AMINO-TERMINAL POCKET.REF J.IMMUNOL. V. 190 1304 2013REFN ISSN 0022-1767PMID 23264655DOI 10.4049/JIMMUNOL.1202446 Variant Set Distributions Ripley’s K […]
General Structure Information 7icp POLB dna polymerase beta (pol b) (e.c.2.7.7.7) complexed with six base pairs of dna; soaked in the presence of zncl2 (0.01 millimolar) 3.0Å AUTH H.PELLETIER,M.R.SAWAYA,W.WOLFLE,S.H.WILSON,J.KRAUTTITL A STRUCTURAL BASIS FOR METAL ION MUTAGENICITY ANDTITL 2 NUCLEOTIDE SELECTIVITY IN HUMAN DNA POLYMERASETITL 3 BETA.REF BIOCHEMISTRY V. 35 12762 1996REFN ISSN 0006-2960PMID 8841119DOI 10.1021/BI9529566 […]
General Structure Information 1xfb ALDOC human brain fructose 1,6-(bis)phosphate aldolase (c isozyme) 3.0Å AUTH T.L.ARAKAKI,J.A.PEZZA,M.A.CRONIN,C.E.HOPKINS,AUTH 2 D.B.ZIMMER,D.R.TOLAN,K.N.ALLENTITL STRUCTURE OF HUMAN BRAIN FRUCTOSETITL 2 1,6-(BIS)PHOSPHATE ALDOLASE: LINKING ISOZYMETITL 3 STRUCTURE WITH FUNCTIONREF PROTEIN SCI. V. 13 3077 2004REFN ISSN 0961-8368PMID 15537755DOI 10.1110/PS.04915904 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1woj CNP crystal structure of human phosphodiesterase 1.8Å AUTH Y.SAKAMOTO,N.TANAKA,T.ICHIMIYA,T.KURIHARA,AUTH 2 K.T.NAKAMURATITL CRYSTAL STRUCTURE OF THE CATALYTIC FRAGMENT OFTITL 2 HUMAN BRAIN 2,3-CYCLIC-NUCLEOTIDETITL 3 3-PHOSPHODIESTERASEREF J.MOL.BIOL. V. 346 789 2005REFN ISSN 0022-2836PMID 15713463DOI 10.1016/J.JMB.2004.12.024 Variant Set Distributions Mapped Variants