Assessment of Structural Intolerance and Durability
General Structure Information 3h3g PTH1R crystal structure of the extracellular domain of the human parathyroid hormone receptor (pth1r) in complex with parathyroid hormone-related protein (pthrp) 1.94Å AUTH A.A.PIOSZAK,N.R.PARKER,T.J.GARDELLA,H.E.XUTITL STRUCTURAL BASIS FOR PARATHYROID HORMONE-RELATED PROTEINTITL 2 BINDING TO THE PARATHYROID HORMONE RECEPTOR AND DESIGN OFTITL 3 CONFORMATION-SELECTIVE PEPTIDES.REF J.BIOL.CHEM. V. 284 28382 2009REFN ISSN 0021-9258PMID 19674967DOI […]
General Structure Information 3zni CBLB structure of phosphotyr363-cbl-b – ubch5b-ub – zap-70 peptide complex 2.21Å AUTH H.DOU,L.BUETOW,G.J.SIBBET,K.CAMERON,D.T.HUANGTITL ESSENTIALITY OF A NON-RING ELEMENT IN PRIMING DONORTITL 2 UBIQUITIN FOR CATALYSIS BY A MONOMERIC E3.REF NAT.STRUCT.MOL.BIOL. V. 20 982 2013REFN ISSN 1545-9993PMID 23851457DOI 10.1038/NSMB.2621 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4lce CTBP1 ctbp1 in complex with substrate mtob 2.38Å AUTH B.J.HILBERT,S.R.GROSSMANN,C.A.SCHIFFER,W.E.ROYERTITL CRYSTAL STRUCTURES OF HUMAN CTBP IN COMPLEX WITH SUBSTRATETITL 2 MTOB REVEAL ACTIVE SITE FEATURES USEFUL FOR INHIBITORTITL 3 DESIGN.REF FEBS LETT. V. 588 1743 2014REFN ISSN 0014-5793PMID 24657618DOI 10.1016/J.FEBSLET.2014.03.026 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1kzz TRAF3 downstream regulator tank binds to the cd40 recognition site on traf3 3.5Å AUTH C.LI,C.Z.NI,M.L.HAVERT,E.CABEZAS,J.HE,D.KAISER,AUTH 2 J.C.REED,A.C.SATTERTHWAIT,G.CHENG,K.R.ELYTITL DOWNSTREAM REGULATOR TANK BINDS TO THE CD40TITL 2 RECOGNITION SITE ON TRAF3.REF STRUCTURE V. 10 403 2002REFN ISSN 0969-2126PMID 12005438DOI 10.1016/S0969-2126(02)00733-5 Variant Set Distributions Mapped Variants
General Structure Information 2leb SRSF2 solution structure of human srsf2 (sc35) rrm in complex with 5- uccagu-3 -1.0Å AUTH G.M.DAUBNER,A.CLERY,S.JAYNE,J.STEVENIN,F.H.ALLAINTITL A SYN-ANTI CONFORMATIONAL DIFFERENCE ALLOWS SRSF2 TOTITL 2 RECOGNIZE GUANINES AND CYTOSINES EQUALLY WELL.REF EMBO J. V. 31 162 2012REFN ISSN 0261-4189PMID 22002536DOI 10.1038/EMBOJ.2011.367 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2g9o ATP7A solution structure of the apo form of the third metal- binding domain of atp7a protein (menkes disease protein) -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,N.DELLAMALVA,AUTH 2 T.HERRMANN,A.ROSATO,K.WUTHRICHTITL SOLUTION STRUCTURE AND INTERMOLECULAR INTERACTIONSTITL 2 OF THE THIRD METAL-BINDING DOMAIN OF ATP7A, THETITL 3 MENKES DISEASE PROTEIN.REF J.BIOL.CHEM. V. 281 29141 2006REFN ISSN 0021-9258PMID 16873374DOI 10.1074/JBC.M603176200 […]
General Structure Information 1pdr DLG1 crystal structure of the third pdz domain from the human homolog of discs large protein 2.8Å AUTH J.H.MORAIS CABRAL,C.PETOSA,M.J.SUTCLIFFE,S.RAZA,AUTH 2 O.BYRON,F.POY,S.M.MARFATIA,A.H.CHISHTI,AUTH 3 R.C.LIDDINGTONTITL CRYSTAL STRUCTURE OF A PDZ DOMAIN.REF NATURE V. 382 649 1996REFN ISSN 0028-0836PMID 8757139DOI 10.1038/382649A0 Variant Set Distributions Mapped Variants
General Structure Information 2y4t DNAJC3 crystal structure of the human co-chaperone p58(ipk) 3.0Å AUTH M.SVARD,E.I.BITEROVA,J.-M.BOURHIS,J.E.GUYTITL THE CRYSTAL STRUCTURE OF THE HUMAN CO-CHAPERONE P58IPKREF PLOS ONE V. 6 22337 2011REFN ISSN 1932-6203PMID 21799829DOI 10.1371/JOURNAL.PONE.0022337 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4a04 TBX1 structure of the dna-bound t-box domain of human tbx1, a transcription factor associated with the digeorge syndrome 2.58Å AUTH K.EL OMARI,J.DE MESMAEKER,D.KARIA,H.GINN,S.BHATTACHARYA,AUTH 2 E.J.MANCINITITL STRUCTURE OF THE DNA-BOUND T-BOX DOMAIN OF HUMAN TBX1, ATITL 2 TRANSCRIPTION FACTOR ASSOCIATED WITH THE DIGEORGE SYNDROMEREF PROTEINS V. 80 655 2012REFN ISSN 0887-3585PMID 22095455DOI […]
General Structure Information 4b4c CHD1 crystal structure of the dna-binding domain of human chd1. 1.62Å AUTH C.K.ALLERSTON,C.D.O.COOPER,L.SHRESTHA,M.VOLLMAR,AUTH 2 N.BURGESS-BROWN,W.W.YUE,E.P.CARPENTER,C.H.ARROWSMITH,AUTH 3 A.EDWARDS,C.BOUNTRA,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURE OF THE DNA-BINDING DOMAIN OF HUMAN CHD1.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants