Assessment of Structural Intolerance and Durability
General Structure Information 3l43 DNM3 crystal structure of the dynamin 3 gtpase domain bound with gdp 2.27Å AUTH S.YANG,W.TEMPEL,Y.TONG,L.NEDYALKOVA,X.GUAN,L.CROMBET,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE DYNAMIN 3 GTPASE DOMAIN BOUND WITHTITL 2 GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2×18 AKT3 the crystal structure of the ph domain of human akt3 protein kinase 1.46Å AUTH M.VOLLMAR,J.WANG,Y.ZHANG,J.M.ELKINS,N.BURGESS-BROWN,AUTH 2 A.CHAIKUAD,A.C.W.PIKE,F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 3 J.WEIGELT,A.EDWARDS,S.KNAPPTITL THE CRYSTAL STRUCTURE OF THE PH DOMAIN OF HUMAN AKT3TITL 2 PROTEIN KINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ch6 NAGK crystal structure of human n-acetylglucosamine kinase in complex with adp and glucose 2.72Å AUTH W.A.WEIHOFEN,M.BERGER,H.CHEN,W.SAENGER,S.HINDERLICHTITL STRUCTURES OF HUMAN N-ACETYLGLUCOSAMINE KINASE IN TWOTITL 2 COMPLEXES WITH N-ACETYLGLUCOSAMINE AND WITH ADP/GLUCOSE:TITL 3 INSIGHTS INTO SUBSTRATE SPECIFICITY AND REGULATION.REF J.MOL.BIOL. V. 364 388 2006REFN ISSN 0022-2836PMID 17010375DOI 10.1016/J.JMB.2006.08.085 Variant Set Distributions Ripley’s K […]
General Structure Information 2pv0 DNMT3L dna methyltransferase 3 like protein (dnmt3l) 3.3Å AUTH S.K.OOI,C.QIU,E.BERNSTEIN,K.LI,D.JIA,Z.YANG,AUTH 2 H.ERDJUMENT-BROMAGE,P.TEMPST,S.P.LIN,C.D.ALLIS,AUTH 3 X.CHENG,T.H.BESTORTITL DNMT3L CONNECTS UNMETHYLATED LYSINE 4 OF HISTONETITL 2 H3 TO DE NOVO METHYLATION OF DNA.REF NATURE V. 448 714 2007REFN ISSN 0028-0836PMID 17687327DOI 10.1038/NATURE05987 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3ue2 PUF60 crystal structure of a rna binding domain of poly-u binding splicing factor 60kda (puf60) from homo sapiens at 1.23 a resolution 1.23Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGYTITL CRYSTAL STRUCTURE OF A RNA BINDING DOMAIN OF POLY-U BINDINGTITL 2 SPLICING FACTOR 60KDA (PUF60) FROM […]
General Structure Information 2pfn POLL na in the active site of dna polymerase lambda 1.9Å AUTH M.GARCIA-DIAZ,K.BEBENEK,J.M.KRAHN,L.C.PEDERSEN,AUTH 2 T.A.KUNKELTITL ROLE OF THE CATALYTIC METAL DURING POLYMERIZATIONTITL 2 BY DNA POLYMERASE LAMBDA.REF DNA REPAIR V. 6 1333 2007REFN ISSN 1568-7864PMID 17475573DOI 10.1016/J.DNAREP.2007.03.005 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3d9i SCAF8 snapshots of the rna processing factor scaf8 bound to different phosphorylated forms of the carboxy-terminal domain of rna-polymerase ii 1.91Å AUTH R.BECKER,B.LOLL,A.MEINHARTTITL SNAPSHOTS OF THE RNA PROCESSING FACTOR SCAF8 BOUND TOTITL 2 DIFFERENT PHOSPHORYLATED FORMS OF THE CARBOXYL-TERMINALTITL 3 DOMAIN OF RNA POLYMERASE II.REF J.BIOL.CHEM. V. 283 22659 2008REFN ISSN […]
General Structure Information 2xah RCOR1 crystal structure of lsd1-corest in complex with (+)- trans-2-phenylcyclopropyl-1-amine 3.1Å AUTH C.BINDA,S.VALENTE,M.ROMANENGHI,S.PILOTTO,R.CIRILLI,AUTH 2 A.KARYTINOS,G.CIOSSANI,O.A.BOTRUGNO,F.FORNERIS,AUTH 3 M.TARDUGNO,D.E.EDMONDSON,S.MINUCCI,A.MATTEVI,A.MAITITL BIOCHEMICAL, STRUCTURAL, AND BIOLOGICAL EVALUATIONTITL 2 OF TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OFTITL 3 HISTONE DEMETHYLASES LSD1 AND LSD2.REF J.AM.CHEM.SOC. V. 132 6827 2010REFN ISSN 0002-7863PMID 20415477DOI 10.1021/JA101557K Variant Set Distributions Mapped Variants
General Structure Information 3hd6 RHCG crystal structure of the human rhesus glycoprotein rhcg 2.1Å AUTH F.GRUSWITZ,S.CHAUDHARY,J.D.HO,A.SCHLESSINGER,B.PEZESHKI,AUTH 2 C.M.HO,A.SALI,C.M.WESTHOFF,R.M.STROUDTITL FUNCTION OF HUMAN RH BASED ON STRUCTURE OF RHCG AT 2.1 A.REF PROC.NATL.ACAD.SCI.USA V. 107 9638 2010REFN ISSN 0027-8424PMID 20457942DOI 10.1073/PNAS.1003587107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2cp3 CLIP2 solution structure of the 2nd cap-gly domain in human clip- 115/cyln2 -1.0Å AUTH K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 2ND CAP-GLY DOMAIN INTITL 2 HUMAN CLIP-115/CYLN2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants