Assessment of Structural Intolerance and Durability
General Structure Information 3nau ZHX2 crystal structure of zhx2 hd2 (zinc-fingers and homeoboxes protein 2, homeodomain 2) 2.7Å AUTH L.E.BIRD,J.REN,J.E.NETTLESHIP,G.E.FOLKERS,R.J.OWENS,AUTH 2 D.K.STAMMERSTITL NOVEL STRUCTURAL FEATURES IN TWO ZHX HOMEODOMAINS DERIVEDTITL 2 FROM A SYSTEMATIC STUDY OF SINGLE AND MULTIPLE DOMAINSREF BMC STRUCT.BIOL. V. 10 13 2010REFN ESSN 1472-6807PMID 20509910DOI 10.1186/1472-6807-10-13 Variant Set Distributions Mapped Variants
General Structure Information 3e77 PSAT1 human phosphoserine aminotransferase in complex with plp 2.5Å AUTH L.LEHTIO,T.KARLBERG,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,AUTH 3 A.FLORES,S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KOTENYOVA,M.MOCHE,M.E.NILSSON,P.NORDLUND,T.NYMAN,K.OLESEN,AUTH 5 C.PERSSON,J.SAGEMARK,S.G.THORSELL,L.TRESAUGUES,AUTH 6 S.VAN DEN BERG,M.WELIN,M.WIKSTROM,M.WISNIEWSKA,J.WEIGELT,AUTH 7 H.SCHUELER,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL HUMAN PHOSPHOSERINE AMINOTRANSFERASE IN COMPLEX WITH PLPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2cu1 MAP3K2 solution structure of the pb1 domain of human protein kinase mekk2b -1.0Å AUTH K.INOUE,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PB1 DOMAIN OF HUMANTITL 2 PROTEIN KINASE MEKK2BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4cc9 VPRBP crystal structure of human samhd1 (amino acid residues 582- 626) bound to vpx isolated from sooty mangabey and human dcaf1 (amino acid residues 1058-1396) 2.47Å AUTH D.SCHWEFEL,H.C.T.GROOM,V.C.BOUCHERIT,E.CHRISTODOULOU,AUTH 2 P.A.WALKER,J.P.STOYE,K.N.BISHOP,I.A.TAYLORTITL STRUCTURAL BASIS OF LENTIVIRAL SUBVERSION OF A CELLULARTITL 2 PROTEIN DEGRADATION PATHWAY.REF NATURE V. 505 234 2014REFN ISSN 0028-0836PMID 24336198DOI 10.1038/NATURE12815 […]
General Structure Information 2nyt APOBEC2 the apobec2 crystal structure and functional implications for aid 2.5Å AUTH C.PROCHNOW,R.BRANSTEITTER,M.G.KLEIN,M.F.GOODMAN,AUTH 2 X.S.CHENTITL THE APOBEC-2 CRYSTAL STRUCTURE AND FUNCTIONALTITL 2 IMPLICATIONS FOR THE DEAMINASE AID.REF NATURE V. 445 447 2007REFN ISSN 0028-0836PMID 17187054DOI 10.1038/NATURE05492 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1x5x FNDC3A solution structure of the fibronectin type-iii domain of human fibronectin type iii domain containing protein 3 -1.0Å AUTH M.YONEYAMA,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIBRONECTIN TYPE-IIITITL 2 DOMAIN OF HUMAN FIBRONECTIN TYPE III DOMAINTITL 3 CONTAINING PROTEIN 3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3enp TPRKB crystal structure of human cgi121 2.48Å AUTH D.Y.MAO,D.NECULAI,M.DOWNEY,S.ORLICKY,Y.Z.HAFFANI,AUTH 2 D.F.CECCARELLI,J.S.HO,R.K.SZILARD,W.ZHANG,C.S.HO,L.WAN,AUTH 3 C.FARES,S.RUMPEL,I.KURINOV,C.H.ARROWSMITH,D.DUROCHER,AUTH 4 F.SICHERITITL ATOMIC STRUCTURE OF THE KEOPS COMPLEX: AN ANCIENT PROTEINTITL 2 KINASE-CONTAINING MOLECULAR MACHINE.REF MOL.CELL V. 32 259 2008REFN ISSN 1097-2765PMID 18951093DOI 10.1016/J.MOLCEL.2008.10.002 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1wk0 FNDC3A solution structure of fibronectin type iii domain derived from human kiaa0970 protein -1.0Å AUTH N.KOBAYASHI,S.KOSHIBA,M.INOUE,F.HAYASHI,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF FIBRONECTIN TYPE III DOMAINTITL 2 DERIVED FROM HUMAN KIAA0970 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4akm LAMP3 crystal structure of the human lysosome-associated membrane protein lamp-3 (aka dc-lamp) 2.69Å AUTH S.WILKE,J.KRAUSZE,K.BUSSOWTITL CRYSTAL STRUCTURE OF THE CONSERVED DOMAIN OF THE DCTITL 2 LYSOSOMAL ASSOCIATED MEMBRANE PROTEIN: IMPLICATIONS FOR THETITL 3 LYSOSOMAL GLYCOCALYX.REF BMC BIOL. V. 10 62 2012REFN ISSN 1741-7007PMID 22809326DOI 10.1186/1741-7007-10-62 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2yhw GNE high-resolution crystal structures of n-acetylmannosamine kinase: insights about substrate specificity, activity and inhibitor modelling. 1.64Å AUTH J.MARTINEZ,L.D.NGUYEN,E.TAUBERGER,S.HINDERLICH,W.REUTTER,AUTH 2 H.FAN,W.SAENGER,S.MONIOTTITL CRYSTAL STRUCTURES OF N-ACETYLMANNOSAMINE KINASE PROVIDETITL 2 INSIGHTS INTO ENZYME SPECIFICITY AND INHIBITIONREF J.BIOL.CHEM. V. 287 13656 2012REFN ISSN 0021-9258PMID 22343627DOI 10.1074/JBC.M111.318170 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]