Assessment of Structural Intolerance and Durability
General Structure Information 2eb1 DICER1 crystal structure of the c-terminal rnase iii domain of human dicer 2.0Å AUTH D.TAKESHITA,S.ZENNO,W.C.LEE,K.NAGATA,K.SAIGO,M.TANOKURATITL HOMODIMERIC STRUCTURE AND DOUBLE-STRANDED RNA CLEAVAGETITL 2 ACTIVITY OF THE C-TERMINAL RNASE III DOMAIN OF HUMAN DICERREF J.MOL.BIOL. V. 374 106 2007REFN ISSN 0022-2836PMID 17920623DOI 10.1016/J.JMB.2007.08.069 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1q7s PTRH2 crystal structure of bit1 2.0Å AUTH J.M.DE PEREDA,W.F.WAAS,Y.JAN,E.RUOSLAHTI,AUTH 2 P.SCHIMMEL,J.PASCUALTITL CRYSTAL STRUCTURE OF A HUMAN PEPTIDYL-TRNATITL 2 HYDROLASE REVEALS A NEW FOLD AND SUGGESTS BASISTITL 3 FOR A BIFUNCTIONAL ACTIVITY.REF J.BIOL.CHEM. V. 279 8111 2004REFN ISSN 0021-9258PMID 14660562DOI 10.1074/JBC.M311449200 Variant Set Distributions Mapped Variants
General Structure Information 4mvt PIAS3 crystal structure of sumo e3 ligase pias3 2.3Å AUTH J.HU,A.DONG,Y.LI,W.TEMPEL,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,Y.TONG,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF SUMO E3 LIGASE PIAS3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4ncs NEU2 human sialidase 2 in complex with 2,3-difluorosialic acid (covalent intermediate) 2.2Å AUTH S.BUCHINI,F.X.GALLAT,I.R.GREIG,J.H.KIM,S.WAKATSUKI,AUTH 2 L.M.CHAVAS,S.G.WITHERSTITL TUNING MECHANISM-BASED INACTIVATORS OF NEURAMINIDASES:TITL 2 MECHANISTIC AND STRUCTURAL INSIGHTS.REF ANGEW.CHEM.INT.ED.ENGL. V. 53 3382 2014REFN ISSN 1433-7851PMID 24591206DOI 10.1002/ANIE.201309675 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lna AFG3L2 solution nmr structure of the mitochondrial inner membrane domain (residues 164-251), ftsh_ext, from the paraplegin-like protein afg3l2 from homo sapiens, northeast structural genomics consortium target hr6741a -1.0Å AUTH T.A.RAMELOT,Y.YANG,I.D.SAHU,H.W.LEE,R.XIAO,G.A.LORIGAN,AUTH 2 G.T.MONTELIONE,M.A.KENNEDYTITL NMR STRUCTURE AND MD SIMULATIONS OF THE AAA PROTEASETITL 2 INTERMEMBRANE SPACE DOMAIN INDICATES PERIPHERAL MEMBRANETITL 3 LOCALIZATION WITHIN […]
General Structure Information 4cff PRKAB1 structure of full length human ampk in complex with a small molecule activator, a thienopyridone derivative (a-769662) 3.92Å AUTH B.XIAO,M.J.SANDERS,D.CARMENA,N.J.BRIGHT,L.F.HAIRE,AUTH 2 E.UNDERWOOD,B.R.PATEL,R.B.HEATH,P.A.WALKER,S.HALLEN,AUTH 3 F.GIORDANETTO,S.R.MARTIN,D.CARLING,S.J.GAMBLINTITL STRUCTURAL BASIS OF AMPK REGULATION BY SMALL MOLECULETITL 2 ACTIVATORS.REF NAT.COMMUN. V. 4 3017 2013REFN ISSN 2041-1723PMID 24352254DOI 10.1038/NCOMMS4017 Variant Set Distributions Mapped Variants
General Structure Information 2eoc PARP3 solution structure of the wgr domain from human poly [adp- ribose] polymerase-3 -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE WGR DOMAIN FROM HUMANTITL 2 POLY [ADP-RIBOSE] POLYMERASE-3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1lb6 TRAF6 traf6-cd40 complex 1.8Å AUTH H.YE,J.R.ARRON,B.LAMOTHE,M.CIRILLI,T.KOBAYASHI,AUTH 2 N.K.SHEVDE,D.SEGAL,O.K.DZIVENU,M.VOLOGODSKAIA,AUTH 3 M.YIM,K.DU,S.SINGH,J.W.PIKE,B.G.DARNAY,Y.CHOI,H.WUTITL DISTINCT MOLECULAR MECHANISM FOR INITIATING TRAF6TITL 2 SIGNALLING.REF NATURE V. 418 443 2002REFN ISSN 0028-0836PMID 12140561DOI 10.1038/NATURE00888 Variant Set Distributions Mapped Variants
General Structure Information 2cxk CAMTA1 crystal structure of the tig domain of human calmodulin- binding transcription activator 1 (camta1) 1.85Å AUTH A.A.PIOSZAK,K.MURAYAMA,M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE TIG DOMAIN OF HUMANTITL 2 CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR 1TITL 3 (CAMTA1)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2oud DUSP10 crystal structure of the catalytic domain of human mkp5 2.8Å AUTH X.TAO,L.TONGTITL CRYSTAL STRUCTURE OF THE MAP KINASE BINDING DOMAINTITL 2 AND THE CATALYTIC DOMAIN OF HUMAN MKP5.REF PROTEIN SCI. V. 16 880 2007REFN ISSN 0961-8368PMID 17400920DOI 10.1110/PS.062712807 Variant Set Distributions Mapped Variants