Assessment of Structural Intolerance and Durability
General Structure Information 4bgj SNX14 crystal structure of the phox-homology domain of human sorting nexin 14 2.55Å AUTH M.VOLLMAR,W.KIYANI,L.SHRESTHA,S.GOUBIN,T.KROJER,A.C.W.PIKE,AUTH 2 E.CARPENTER,A.QUIGLEY,A.MCKENZIE,N.BURGESS-BROWN,AUTH 3 F.VON DELFT,C.H.ARROWSMITH,C.BOUNTRA,A.EDWARDS,W.W.YUETITL CRYSTAL STRUCTURE OF THE PHOX-HOMOLOGY DOMAIN OF HUMANTITL 2 SORTING NEXIN 14REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2pid YARS2 crystal structure of human mitochondrial tyrosyl-trna synthetase in complex with an adenylate analog 2.2Å AUTH L.BONNEFOND,M.FRUGIER,E.TOUZE,B.LORBER,C.FLORENTZ,R.GIEGE,AUTH 2 C.SAUTER,J.RUDINGER-THIRIONTITL CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL TYROSYL-TRNATITL 2 SYNTHETASE REVEALS COMMON AND IDIOSYNCRATIC FEATURES.REF STRUCTURE V. 15 1505 2007REFN ISSN 0969-2126PMID 17997975DOI 10.1016/J.STR.2007.09.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3l8n ARFGEF2 crystal structure of a domain of brefeldin a-inhibited guanine nucleotide-exchange protein 2 (brefeldina-inhibited gep 2) from homo sapiens (human). northeast structural genomics consortium target id hr5562a 2.86Å AUTH J.SEETHARAMAN,M.SU,F.FOROUHAR,D.WANG,H.JANJUA,AUTH 2 K.CUNNINGHAM,L.OWENS,R.XIAO,J.LIU,M.C.BARAN,AUTH 3 T.B.ACTON,G.T.MONTELIONE,J.F.HUNT,L.TONGTITL CRYSTAL STRUCTURE OF A DOMAIN OF BREFELDINTITL 2 A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 2TITL 3 (BREFELDINA-INHIBITED GEP 2) […]
General Structure Information 3bd0 MEMO1 crystal structure of memo, form ii 3.01Å AUTH C.QIU,S.LIENHARD,N.E.HYNES,A.BADACHE,D.J.LEAHYTITL MEMO IS HOMOLOGOUS TO NONHEME IRON DIOXYGENASESTITL 2 AND BINDS AN ERBB2-DERIVED PHOSPHOPEPTIDE IN ITSTITL 3 VESTIGIAL ACTIVE SITE.REF J.BIOL.CHEM. V. 283 2734 2008REFN ISSN 0021-9258PMID 18045866DOI 10.1074/JBC.M703523200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2lgr OARD1 solution structure of human protein c6orf130, a putative macro domain -1.0Å AUTH F.C.PETERSON,D.CHEN,B.L.LYTLE,M.N.ROSSI,I.AHEL,J.M.DENU,AUTH 2 B.F.VOLKMANTITL ORPHAN MACRODOMAIN PROTEIN (HUMAN C6ORF130) IS ANTITL 2 O-ACYL-ADP-RIBOSE DEACYLASE: SOLUTION STRUCTURE ANDTITL 3 CATALYTIC PROPERTIES.REF J.BIOL.CHEM. V. 286 35955 2011REFN ISSN 0021-9258PMID 21849506DOI 10.1074/JBC.M111.276238 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4l7r PARP3 human artd3 (parp3) – catalytic domain in complex with inhibitor me0400 2.2Å AUTH A.E.LINDGREN,T.KARLBERG,T.EKBLAD,S.SPJUT,A.G.THORSELL,AUTH 2 C.D.ANDERSSON,T.T.NHAN,V.HELLSTEN,J.WEIGELT,A.LINUSSON,AUTH 3 H.SCHULER,M.ELOFSSONTITL CHEMICAL PROBES TO STUDY ADP-RIBOSYLATION: SYNTHESIS ANDTITL 2 BIOCHEMICAL EVALUATION OF INHIBITORS OF THE HUMANTITL 3 ADP-RIBOSYLTRANSFERASE ARTD3/PARP3.REF J.MED.CHEM. V. 56 9556 2013REFN ISSN 0022-2623PMID 24188023DOI 10.1021/JM401394U Variant Set Distributions Ripley’s K […]
General Structure Information 4lx1 MYO5A crystal structure of myo5a globular tail domain 1.87Å AUTH O.PYLYPENKO,W.ATTANDA,C.GAUQUELIN,M.LAHMANI,D.COULIBALY,AUTH 2 B.BARON,S.HOOS,M.A.TITUS,P.ENGLAND,A.M.HOUDUSSETITL STRUCTURAL BASIS OF MYOSIN V RAB GTPASE-DEPENDENT CARGOTITL 2 RECOGNITION.REF PROC.NATL.ACAD.SCI.USA V. 110 20443 2013REFN ISSN 0027-8424PMID 24248336DOI 10.1073/PNAS.1314329110 Variant Set Distributions Mapped Variants
General Structure Information 3uk6 RUVBL2 crystal structure of the tip48 (tip49b) hexamer 2.95Å AUTH M.PETUKHOV,A.DAGKESSAMANSKAJA,M.BOMMER,T.BARRETT,I.TSANEVA,AUTH 2 A.YAKIMOV,R.QUEVAL,A.SHVETSOV,M.KHODORKOVSKIY,E.KAS,AUTH 3 M.GRIGORIEVTITL LARGE-SCALE CONFORMATIONAL FLEXIBILITY DETERMINES THETITL 2 PROPERTIES OF AAA+ TIP49 ATPASES.REF STRUCTURE V. 20 1321 2012REFN ISSN 0969-2126PMID 22748767DOI 10.1016/J.STR.2012.05.012 Variant Set Distributions Mapped Variants
General Structure Information 4iqm PUS1 crystal structure of the catalytic domain of human pus1 1.8Å AUTH N.CZUDNOCHOWSKI,A.L.WANG,J.FINER-MOORE,R.M.STROUDTITL IN HUMAN PSEUDOURIDINE SYNTHASE 1 (HPUS1), A C-TERMINALTITL 2 HELICAL INSERT BLOCKS TRNA FROM BINDING IN THE SAMETITL 3 ORIENTATION AS IN THE PUS1 BACTERIAL HOMOLOGUE TRUA,TITL 4 CONSISTENT WITH THEIR DIFFERENT TARGET SELECTIVITIES.REF J.MOL.BIOL. V. 425 3875 […]
General Structure Information 1v27 RIMS2 solution structure of the first c2 domain of rim2 -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST C2 DOMAIN OF RIM2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants