1V27.A | RIMS2

General Structure Information

PDB ID	1v27
HGNC Gene Label(s)	RIMS2
Structure Name	solution structure of the first c2 domain of rim2
Resolution	-1.0Å
Reference	AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST C2 DOMAIN OF RIM2REF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	128
Number Of SNVs	35
Number Of Permutations	14389
Optimal Distance Threshold	13.0
K Statistic	0.146
p-value	0.001

COSMIC

Number Of Residues	128
Number Of SNVs	7
Number Of Permutations	1671
Optimal Distance Threshold	8.0
K Statistic	0.143
p-value	0.335

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	35
Number Of COSMIC SNVs	5
Optimal Distance Threshold	13.0
K Statistic	0.454
p-value	0.01

Pathogenic Proximity Analysis

COSMIC PathProx Analysis

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
8:104943491	rs201336825	I>V	A:12	(-5.14, -1.78, 2.01)
8:104943518		H>D	A:21	(-14.24, 17.12, -0.12)
8:104943539	rs544268851	L>V	A:28	(-5.71, -2.84, 8.18)
8:104943546		A>G	A:30	(0.30, -8.05, 5.62)
8:104943552	rs61753731	D>A	A:32	(-0.45, -15.31, 3.97)
8:104943558	rs376434557 COSM1223774 COSM1223773 COSM1223770 COSM1223772 COSM1223771	P>R	A:34	(6.31, -14.36, 0.59)
8:104943563		R>G	A:36	(12.27, -18.23, 6.85)
8:104943566		E>Q	A:37	(12.41, -23.05, 4.06)
8:104943573		G>E	A:39	(16.14, -19.33, 7.89)
8:104943577	rs183274467	R>S	A:40	(16.68, -15.63, 10.96)
8:104943585		N>S	A:43	(12.39, -6.21, 7.13)
8:104943600		I>T	A:48	(0.29, 4.30, 0.37)
8:104943617		R>G	A:54	(5.86, 6.72, -8.55)
8:104948782	rs373835551 COSM1242781 COSM1242780 COSM1242777 COSM1242779 COSM1242778	D>E	A:56	(7.47, 13.16, -2.51)
8:104948787	COSM1094576 COSM1094575 COSM1597295 COSM1094574 COSM1597296	N>S	A:58	(1.07, 13.02, -2.96)
8:104948805		T>R	A:64	(10.09, -0.81, 8.04)
8:104948835	rs199836073	N>S	A:74	(-3.72, -1.04, 11.73)
8:104948836		N>K	A:74	(-3.72, -1.04, 11.73)
8:104948840		T>A	A:76	(-4.69, 6.85, 9.44)
8:104948853		S>F	A:80	(-7.01, 16.47, 1.23)
8:104948858		V>I	A:82	(-9.61, 13.79, -2.27)
8:104948867	rs371602210	R>G	A:85	(-15.81, 15.87, -8.08)
8:104948868		R>K	A:85	(-15.81, 15.87, -8.08)
8:104948874		F>C	A:87	(-12.21, 9.07, -6.08)
8:104948876	rs556481632	R>W	A:88	(-12.01, 10.05, -14.68)
8:104948877	rs574267282 COSM3833798 COSM3833797 COSM3833794 COSM3833796 COSM3833795	R>Q	A:88	(-12.01, 10.05, -14.68)
8:104948906		D>N	A:98	(11.47, -6.90, 1.71)
8:104948915	COSM404100 COSM404099 COSM1597293 COSM404098 COSM1597294	R>C	A:101	(21.37, -5.45, 0.65)
8:104948916	COSM3395040 COSM3395039 COSM3395036 COSM3395038 COSM3395037	R>H	A:101	(21.37, -5.45, 0.65)
8:104948918		V>F	A:102	(21.20, -1.73, 5.59)
8:104948930	COSM1223791 COSM1223790 COSM1223787 COSM1223789 COSM1223788	E>K	A:106	(18.47, -3.54, -2.66)
8:104948939		F>L	A:109	(7.76, -6.08, -6.12)
8:104955010	rs199576216	E>K	A:116	(-8.85, 2.62, -10.05)
8:104955020		T>I	A:119	(-13.82, 1.49, -9.50)
8:104955026		L>S	A:121	(-14.05, -1.64, -2.55)
8:104955031		D>N	A:123	(-17.49, 0.73, 2.99)
8:104955037		E>K	A:125	(-14.74, -2.25, 4.63)
8:104955062	COSM1453829 COSM1453828 COSM1453825 COSM1453827 COSM1453826	T>M	A:133	(3.89, -10.77, -8.26)
8:104955067	COSM3728273 COSM3728272 COSM3728269 COSM3728271 COSM3728270	D>H	A:135	(7.40, -6.75, -14.02)

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
8:104934008	COSM164022	L>R	A:10	(-1.67, -5.86, 2.13)
8:104943536	COSM1755495	I>V	A:27	(-1.80, 0.54, 5.18)
8:104943591	COSM1755499	Y>F	A:45	(8.33, -1.75, 2.61)
8:104943609	COSM1453805	L>P	A:51	(-0.54, 7.79, -8.69)
8:104943618	COSM1623471	R>K	A:54	(5.86, 6.72, -8.55)
8:104948865	COSM200344	R>Q	A:84	(-16.51, 9.99, -6.29)
8:104948915	COSM1597294	R>C	A:101	(21.37, -5.45, 0.65)
8:104955055	COSM1674069	L>F	A:131	(0.19, -8.74, -2.87)

1V27.A | RIMS2.

1V27.A | RIMS2

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Pathogenic Proximity Analysis

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants