Assessment of Structural Intolerance and Durability
General Structure Information 3lxx GIMAP4 crystal structure of human gtpase imap family member 4 2.15Å AUTH Y.SHEN,L.NEDYALKOVA,Y.TONG,W.TEMPEL,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,D.W.ANDREWS,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN GTPASE IMAP FAMILYTITL 2 MEMBER 4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2io1 SENP2 crystal structure of human senp2 in complex with presumo-3 2.6Å AUTH D.REVERTER,C.D.LIMATITL STRUCTURAL BASIS FOR SENP2 PROTEASE INTERACTIONSTITL 2 WITH SUMO PRECURSORS AND CONJUGATED SUBSTRATES.REF NAT.STRUCT.MOL.BIOL. V. 13 1060 2006REFN ISSN 1545-9993PMID 17099700DOI 10.1038/NSMB1168 Variant Set Distributions Mapped Variants
General Structure Information 2y43 RAD18 rad18 ubiquitin ligase ring domain structure 1.8Å AUTH A.HUANG,R.G.HIBBERT,R.N.DE JONG,D.DAS,T.K.SIXMA,R.BOELENSTITL SYMMETRY AND ASYMMETRY OF THE RING-RING DIMER OF RAD18.REF J.MOL.BIOL. V. 410 424 2011REFN ISSN 0022-2836PMID 21549715DOI 10.1016/J.JMB.2011.04.051 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ijd PRDM9 crystal structure of methyltransferase domain of human pr domain- containing protein 9 2.15Å AUTH L.DOMBROVSKI,A.DONG,Y.LI,W.TEMPEL,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,P.J.BROWN,H.WU,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMAN PRTITL 2 DOMAIN-CONTAINING PROTEIN 9REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2cmw CSNK1G1 structure of human casein kinase 1 gamma-1 in complex with 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9- isopropylpurine (casp target) 1.75Å AUTH G.BUNKOCZI,P.RELLOS,S.DAS,P.SAVITSKY,F.NIESEN,F.SOBOTT,AUTH 2 O.FEDOROV,A.C.W.PIKE,F.VON DELFT,M.SUNDSTROM,C.ARROWSMITH,AUTH 3 A.EDWARDS,J.WEIGELT,S.KNAPPTITL STRUCTURE OF HUMAN CASEIN KINASE 1 GAMMA-1 IN COMPLEX WITHTITL 2 2-(2-HYDROXYETHYLAMINO)-6-TITL 3 (3-CHLOROANILINO)-9-ISOPROPYLPURINE (CASP TARGET)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3zdk DCLRE1B crystal structure of human 5 exonuclease apollo 2.16Å AUTH C.K.ALLERSTON,M.VOLLMAR,T.KROJER,A.C.W.PIKE,E.CARPENTER,AUTH 2 A.QUIGLEY,P.MAHAJAN,F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 3 A.EDWARDS,O.GILEADITITL CRYSTAL STRUCTURE OF HUMAN 5 EXONUCLEASE APOLLOREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2vhf CYLD structure of the cyld usp domain 2.8Å AUTH D.KOMANDER,C.J.LORD,H.SCHEEL,S.SWIFT,K.HOFMANN,AUTH 2 A.ASHWORTH,D.BARFORDTITL THE STRUCTURE OF THE CYLD USP DOMAIN EXPLAINS ITSTITL 2 SPECIFICITY FOR LYS63-LINKED POLYUBIQUITIN ANDTITL 3 REVEALS A B-BOX MODULEREF MOL.CELL.BIOL. V. 29 451 2008REFN ISSN 0270-7306PMID 18313383DOI 10.1016/J.MOLCEL.2007.12.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2dl6 CHD8 solution structure of the first brk domain from human chromodomain-helicase-dna-binding protein 8 -1.0Å AUTH T.SUETAKE,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST BRK DOMAIN FROMTITL 2 HUMAN CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2fe4 RAB6B the crystal structure of human neuronal rab6b in its inactive gdp-bound form 2.3Å AUTH I.GARCIA-SAEZ,S.TCHERNIUK,F.KOZIELSKITITL THE STRUCTURE OF HUMAN NEURONAL RAB6B IN THETITL 2 ACTIVE AND INACTIVE FORM.REF ACTA CRYSTALLOGR.,SECT.D V. 62 725 2006REFN ISSN 0907-4449PMID 16790928DOI 10.1107/S0907444906015319 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2z0b GPCPD1 crystal structure of cbm20 domain of human putative glycerophosphodiester phosphodiesterase 5 (kiaa1434) 2.0Å AUTH S.SAIJO,A.NISHINO,S.KISHISHITA,M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF CBM20 DOMAIN OF HUMAN PUTATIVETITL 2 GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 5 (KIAA1434)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants