Assessment of Structural Intolerance and Durability
General Structure Information 1c9q XIAP average nmr solution structure of the bir-2 domain of xiap -1.0Å AUTH C.SUN,M.CAI,A.H.GUNASEKERA,R.P.MEADOWS,H.WANG,AUTH 2 J.CHEN,H.ZHANG,W.WU,N.XU,S.C.NG,S.W.FESIKTITL NMR STRUCTURE AND MUTAGENESIS OF THETITL 2 INHIBITOR-OF-APOPTOSIS PROTEIN XIAP.REF NATURE V. 401 818 1999REFN ISSN 0028-0836PMID 10548111DOI 10.1038/44617 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3l1z UBE2D3 crystal structure of the u-box domain of human e4b ubiquitin ligase in complex with ubch5c e2 ubiquitin conjugating enzyme 3.17Å AUTH R.C.BENIRSCHKE,J.R.THOMPSON,Y.NOMINE,E.WASIELEWSKI,AUTH 2 N.JURANIC,S.MACURA,S.HATAKEYAMA,K.I.NAKAYAMA,M.V.BOTUYAN,AUTH 3 G.MERTITL MOLECULAR BASIS FOR THE ASSOCIATION OF HUMAN E4B U BOXTITL 2 UBIQUITIN LIGASE WITH E2-CONJUGATING ENZYMES UBCH5C ANDTITL 3 UBC4.REF STRUCTURE V. 18 955 […]
General Structure Information 2leo SPINK7 solution structure of esophageal cancer-related gene 2 -1.0Å AUTH Y.FENG,Y.GENG,T.ZHOU,J.WANGTITL NMR STRUCTURE NOTE: HUMAN ESOPHAGEAL CANCER-RELATED GENE 2REF J.BIOMOL.NMR V. 53 65 2012REFN ISSN 0925-2738PMID 22528291DOI 10.1007/S10858-012-9622-9 Variant Set Distributions Mapped Variants
General Structure Information 2m0p LRP2 solution structure of the tenth complement type repeat of human megalin -1.0Å AUTH R.DAGIL,C.OSHEA,A.NYKJAR,A.M.BONVIN,B.B.KRAGELUNDTITL GENTAMICIN BINDS TO THE MEGALIN RECEPTOR AS A COMPETITIVETITL 2 INHIBITOR USING THE COMMON LIGAND BINDING MOTIF OFTITL 3 COMPLEMENT TYPE REPEATS: INSIGHT FROM THE NMR STRUCTURE OFTITL 4 THE 10TH COMPLEMENT TYPE REPEAT DOMAIN ALONE […]
General Structure Information 1b4r PKD1 pkd domain 1 from human polycystein-1 -1.0Å AUTH M.BYCROFT,A.BATEMAN,J.CLARKE,S.J.HAMILL,R.SANDFORD,AUTH 2 R.L.THOMAS,C.CHOTHIATITL THE STRUCTURE OF A PKD DOMAIN FROM POLYCYSTIN-1:TITL 2 IMPLICATIONS FOR POLYCYSTIC KIDNEY DISEASE.REF EMBO J. V. 18 297 1999REFN ISSN 0261-4189PMID 9889186DOI 10.1093/EMBOJ/18.2.297 Variant Set Distributions Mapped Variants
General Structure Information 3dlx OXCT1 crystal structure of human 3-oxoacid coa transferase 1 2.2Å AUTH K.L.KAVANAGH,N.SHAFQAT,W.W.YUE,S.PICAUD,J.W.MURRAY,AUTH 2 E.M.MACLEAN,F.VON DELFT,A.K.ROOS,C.H.ARROWSMITH,M.WIKSTROM,AUTH 3 A.M.EDWARDS,C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN 3-OXOACID COA TRANSFERASE 1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4cc1 JAG1 notch ligand, jagged-1, contains an n-terminal c2 domain 2.84Å AUTH C.R.CHILAKURI,D.SHEPPARD,M.X.G.ILAGAN,L.R.HOLT,F.ABBOTT,AUTH 2 S.LIANG,R.KOPAN,P.A.HANDFORD,S.M.LEATITL STRUCTURAL ANALYSIS UNCOVERS LIPID-BINDING PROPERTIES OFTITL 2 NOTCH LIGANDSREF CELL REP. V. 5 861 2013REFN ISSN 2211-1247PMID 24239355DOI 10.1016/J.CELREP.2013.10.029 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2g2k EIF5 nmr structure of an n-terminal fragment of the eukaryotic initiation factor 5 (eif5) -1.0Å AUTH M.R.CONTE,G.KELLY,J.BABON,D.SANFELICE,J.YOUELL,AUTH 2 S.J.SMERDON,C.G.PROUDTITL STRUCTURE OF THE EUKARYOTIC INITIATION FACTORTITL 2 (EIF) 5 REVEALS A FOLD COMMON TO SEVERALTITL 3 TRANSLATION FACTORSREF BIOCHEMISTRY V. 45 4550 2006REFN ISSN 0006-2960PMID 16584190DOI 10.1021/BI052387U Variant Set Distributions Mapped Variants
General Structure Information 3ub2 TIRAP tir domain of mal/tirap 2.4Å AUTH Z.LIN,J.LU,W.ZHOU,Y.SHENTITL STRUCTURAL INSIGHTS INTO TIR DOMAIN SPECIFICITY OF THETITL 2 BRIDGING ADAPTOR MAL IN TLR4 SIGNALINGREF PLOS ONE V. 7 34202 2012REFN ESSN 1932-6203PMID 22485159DOI 10.1371/JOURNAL.PONE.0034202 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1dks CKS1B ckshs1: human cyclin dependent kinase subunit, type 1 in complex with phosphate 3.2Å AUTH A.S.ARVAI,Y.BOURNE,M.J.HICKEY,J.A.TAINERTITL CRYSTAL STRUCTURE OF THE HUMAN CELL CYCLE PROTEINTITL 2 CKSHS1: SINGLE DOMAIN FOLD WITH SIMILARITY TOTITL 3 KINASE N-LOBE DOMAIN.REF J.MOL.BIOL. V. 249 835 1995REFN ISSN 0022-2836PMID 7791211DOI 10.1006/JMBI.1995.0341 Variant Set Distributions Mapped Variants