Assessment of Structural Intolerance and Durability
General Structure Information 2shp PTPN11 tyrosine phosphatase shp-2 2.0Å AUTH P.HOF,S.PLUSKEY,S.DHE-PAGANON,M.J.ECK,S.E.SHOELSONTITL CRYSTAL STRUCTURE OF THE TYROSINE PHOSPHATASETITL 2 SHP-2.REF CELL(CAMBRIDGE,MASS.) V. 92 441 1998REFN ISSN 0092-8674PMID 9491886DOI 10.1016/S0092-8674(00)80938-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3qxm GRIK2 crystal structure of human gluk2 ligand-binding core in complex with novel marine-derived toxins, neodysiherbaine a 1.65Å AUTH M.UNNO,M.SHINOHARA,K.TAKAYAMA,H.TANAKA,K.TERUYA,K.DOH-URA,AUTH 2 R.SAKAI,M.SASAKI,M.IKEDA-SAITOTITL BINDING AND SELECTIVITY OF THE MARINE TOXIN NEODYSIHERBAINETITL 2 A AND ITS SYNTHETIC ANALOGUES TO GLUK1 AND GLUK2 KAINATETITL 3 RECEPTORS.REF J.MOL.BIOL. V. 413 667 2011REFN ISSN 0022-2836PMID 21893069DOI 10.1016/J.JMB.2011.08.043 […]
General Structure Information 1n52 NCBP1 cap binding complex 2.11Å AUTH G.CALERO,K.WILSON,T.LY,J.RIOS-STEINER,J.CLARDY,R.CERIONETITL STRUCTURAL BASIS OF M7GPPPG BINDING TO THE NUCLEARTITL 2 CAP-BINDING PROTEIN COMPLEX.REF NAT.STRUCT.BIOL. V. 9 912 2002REFN ISSN 1072-8368PMID 12434151DOI 10.1038/NSB874 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1b22 RAD51 rad51 (n-terminal domain) -1.0Å AUTH H.AIHARA,Y.ITO,H.KURUMIZAKA,S.YOKOYAMA,T.SHIBATATITL THE N-TERMINAL DOMAIN OF THE HUMAN RAD51 PROTEINTITL 2 BINDS DNA: STRUCTURE AND A DNA BINDING SURFACE ASTITL 3 REVEALED BY NMR.REF J.MOL.BIOL. V. 290 495 1999REFN ISSN 0022-2836PMID 10390347DOI 10.1006/JMBI.1999.2904 Variant Set Distributions Mapped Variants
General Structure Information 2obh XPC centrin-xpc peptide 1.8Å AUTH J.B.CHARBONNIER,E.RENAUD,S.MIRON,M.H.LE DU,Y.BLOUQUIT,AUTH 2 P.DUCHAMBON,P.CHRISTOVA,A.SHOSHEVA,T.ROSE,J.F.ANGULO,AUTH 3 C.T.CRAESCUTITL STRUCTURAL, THERMODYNAMIC, AND CELLULAR CHARACTERIZATION OFTITL 2 HUMAN CENTRIN 2 INTERACTION WITH XERODERMA PIGMENTOSUM GROUPTITL 3 C PROTEIN.REF J.MOL.BIOL. V. 373 1032 2007REFN ISSN 0022-2836PMID 17897675DOI 10.1016/J.JMB.2007.08.046 Variant Set Distributions Mapped Variants
General Structure Information 1zsx KCNAB2 crystal structure of human potassium channel kv beta-subunit (kcnab2) 1.9Å AUTH P.WENNERSTRAND,I.JOHANNSSON,E.UGOCHUKWU,K.KAVANAGH,AUTH 2 A.EDWARDS,C.ARROWSMITH,L.WILLIAMS,M.SUNDSTROM,K.GUO,AUTH 3 F.VON DELFT,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN POTASSIUM CHANNEL KV BETA-SUBUNITTITL 2 (KCNAB2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2knx LRP1 solution structure of complement repeat cr17 from lrp-1 -1.0Å AUTH M.GUTTMAN,J.H.PRIETO,T.M.HANDEL,P.J.DOMAILLE,E.A.KOMIVESTITL STRUCTURE OF THE MINIMAL INTERFACE BETWEEN APOE AND LRP.REF J.MOL.BIOL. V. 398 306 2010REFN ISSN 0022-2836PMID 20303980DOI 10.1016/J.JMB.2010.03.022 Variant Set Distributions Mapped Variants
General Structure Information 3f3y SULT2A1 crystal structure of human cytosolic sulfotransferase sult2a1 in complex with pap and lithocholic acid 2.2Å AUTH P.W.PAN,A.DONG,M.AMAYA,A.M.EDWARDSTITL RYSTAL STRUCTURE OF HUMAN CYTOSOLICTITL 2 SULFOTRANSFERASE SULT2A1 IN COMPLEX WITH PAP ANDTITL 3 LITHOCHOLIC ACIDREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2dbj MERTK solution structures of the fn3 domain of human proto- oncogene tyrosine-protein kinase mer precursor -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE FN3 DOMAIN OF HUMANTITL 2 PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MERTITL 3 PRECURSORREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3vw9 GLO1 human glyoxalase i with an n-hydroxypyridone inhibitor 1.47Å AUTH T.CHIBA,J.OHWADA,H.SAKAMOTO,T.KOBAYASHI,T.A.FUKAMI,M.IRIE,AUTH 2 T.MIURA,K.OHARA,H.KOYANOTITL DESIGN AND EVALUATION OF AZAINDOLE-SUBSTITUTEDTITL 2 N-HYDROXYPYRIDONES AS GLYOXALASE I INHIBITORSREF BIOORG.MED.CHEM.LETT. V. 22 7486 2012REFN ISSN 0960-894XPMID 23122816DOI 10.1016/J.BMCL.2012.10.045 Variant Set Distributions Mapped Variants