Assessment of Structural Intolerance and Durability
General Structure Information 3gf9 ITSN2 crystal structure of human intersectin 2 rhogef domain 2.5Å AUTH Y.SHEN,Y.TONG,W.TEMPEL,Y.LI,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN INTERSECTIN 2 RHOGEFTITL 2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lkm MORF4L1 structural basis for molecular interactions involving mrg domains: implications in chromatin biology -1.0Å AUTH T.XIE,R.GRAVELINE,G.S.KUMAR,Y.ZHANG,A.KRISHNAN,G.DAVID,AUTH 2 I.RADHAKRISHNANTITL STRUCTURAL BASIS FOR MOLECULAR INTERACTIONS INVOLVING MRGTITL 2 DOMAINS: IMPLICATIONS IN CHROMATIN BIOLOGY.REF STRUCTURE V. 20 151 2012REFN ISSN 0969-2126PMID 22244764DOI 10.1016/J.STR.2011.10.019 Variant Set Distributions Mapped Variants
General Structure Information 1wr6 GGA3 crystal structure of gga3 gat domain in complex with ubiquitin 2.6Å AUTH M.KAWASAKI,T.SHIBA,Y.SHIBA,Y.YAMAGUCHI,N.MATSUGAKI,AUTH 2 N.IGARASHI,M.SUZUKI,R.KATO,K.KATO,K.NAKAYAMA,AUTH 3 S.WAKATSUKITITL MOLECULAR MECHANISM OF UBIQUITIN RECOGNITION BYTITL 2 GGA3 GAT DOMAIN.REF GENES CELLS V. 10 639 2005REFN ISSN 1356-9597PMID 15966896DOI 10.1111/J.1365-2443.2005.00865.X Variant Set Distributions Mapped Variants
General Structure Information 2l0f POLI solution nmr structure of human polymerase iota ubm2 (p692a mutant) in complex with ubiquitin -1.0Å AUTH G.CUI,R.C.BENIRSCHKE,H.F.TUAN,N.JURANIC,S.MACURA,AUTH 2 M.V.BOTUYAN,G.MERTITL STRUCTURAL BASIS OF UBIQUITIN RECOGNITION BY TRANSLESIONTITL 2 SYNTHESIS DNA POLYMERASE IOTA.REF BIOCHEMISTRY V. 49 10198 2010REFN ISSN 0006-2960PMID 21049971DOI 10.1021/BI101303T Variant Set Distributions Mapped Variants
General Structure Information 1zq9 DIMT1 crystal structure of human dimethyladenosine transferase 1.9Å AUTH H.WU,A.DONG,H.ZENG,P.LOPPNAU,M.SUNDSTROM,AUTH 2 C.ARROWSMITH,A.EDWARDS,A.BOCHKAREV,A.PLOTNIKOVTITL CRYSTAL STRUCTURE OF HUMAN DIMETHYLADENOSINETITL 2 TRANSFERASE WITH SAMREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3nar ZHX1 crystal structure of zhx1 hd4 (zinc-fingers and homeoboxes protein 1, homeodomain 4) 2.6Å AUTH L.E.BIRD,J.REN,J.E.NETTLESHIP,G.E.FOLKERS,R.J.OWENS,AUTH 2 D.K.STAMMERSTITL NOVEL STRUCTURAL FEATURES IN TWO ZHX HOMEODOMAINS DERIVEDTITL 2 FROM A SYSTEMATIC STUDY OF SINGLE AND MULTIPLE DOMAINSREF BMC STRUCT.BIOL. V. 10 13 2010REFN ESSN 1472-6807PMID 20509910DOI 10.1186/1472-6807-10-13 Variant Set Distributions Mapped Variants
General Structure Information 2bye PLCE1 nmr solution structure of phospholipase c epsilon ra 1 domain -1.0Å AUTH T.D.BUNNEY,R.HARRIS,N.L.GANDARILLAS,M.B.JOSEPHS,AUTH 2 S.M.ROE,S.C.SORLI,H.F.PATERSON,F.RODRIGUES-LIMA,AUTH 3 D.ESPOSITO,C.P.PONTING,P.GIERSCHIK,L.H.PEARL,AUTH 4 P.C.DRISCOLL,M.KATANTITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO RASTITL 2 ASSOCIATION DOMAINS OF PHOSPHOLIPASE C EPSILON.REF MOL.CELL V. 21 495 2006REFN ISSN 1097-2765PMID 16483931DOI 10.1016/J.MOLCEL.2006.01.008 Variant Set Distributions Mapped Variants
General Structure Information 3db5 PRDM4 crystal structure of methyltransferase domain of human pr domain- containing protein 4 2.15Å AUTH H.ZENG,M.F.AMAYA,P.LOPPNAU,A.BOCHKAREV,J.MIN,A.N.PLOTNIKOV,AUTH 2 H.WUTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMANTITL 2 PR DOMAIN-CONTAINING PROTEIN 4.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1ue9 ITSN2 solution structure of the fourth sh3 domain of human intersectin 2 (kiaa1256) -1.0Å AUTH N.TOCHIO,T.KIGAWA,S.KOSHIBA,N.KOBAYASHI,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FOURTH SH3 DOMAIN OFTITL 2 HUMAN INTERSECTIN 2 (KIAA1256)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dhz RAPGEFL1 solution structure of the ra domain in the human link guanine nucleotide exchange factor ii (link-gefii) -1.0Å AUTH C.ZHAO,T.KIGAWA,M.YONEYAMA,S.KOSHIBA,T.HARADA,AUTH 2 S.WATANABE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RA DOMAIN IN THE HUMANTITL 2 LINK GUANINE NUCLEOTIDE EXCHANGE FACTOR IITITL 3 (LINK-GEFII)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants