Assessment of Structural Intolerance and Durability
General Structure Information 1ft8 NXF1 crystal structure of the rna-binding domain of the mrna export factor tap 3.15Å AUTH E.LIKER,E.FERNANDEZ,E.IZAURRALDE,E.CONTITITL THE STRUCTURE OF THE MRNA EXPORT FACTOR TAPTITL 2 REVEALS A CIS ARRANGEMENT OF A NON-CANONICAL RNPTITL 3 DOMAIN AND AN LRR DOMAIN.REF EMBO J. V. 19 5587 2000REFN ISSN 0261-4189PMID 11060011DOI 10.1093/EMBOJ/19.21.5587 Variant Set […]
General Structure Information 1ujk GGA1 vhs domain of human gga1 complexed with c-terminal phosphopeptide from bace 1.9Å AUTH T.SHIBA,S.KAMETAKA,M.KAWASAKI,M.SHIBATA,S.WAGURI,AUTH 2 Y.UCHIYAMA,S.WAKATSUKITITL INSIGHTS INTO THE PHOSPHOREGULATION OFTITL 2 BETA-SECRETASE SORTING SIGNAL BY THE VHS DOMAIN OFTITL 3 GGA1REF TRAFFIC V. 5 437 2004REFN ISSN 1398-9219PMID 15117318DOI 10.1111/J.1600-0854.2004.00188.X Variant Set Distributions Mapped Variants
General Structure Information 2qq8 TBC1D14 crystal structure of the putative rabgap domain of human tbc1 domain family member 14 2.0Å AUTH Y.TONG,W.TEMPEL,S.DIMOV,R.LANDRY,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE PUTATIVE RABGAP DOMAIN OFTITL 2 HUMAN TBC1 DOMAIN FAMILY MEMBER 14.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1n1f IL19 crystal structure of human interleukin-19 1.95Å AUTH C.CHANG,E.MAGRACHEVA,S.KOZLOV,S.FONG,G.TOBIN,S.KOTENKO,AUTH 2 A.WLODAWER,A.ZDANOVTITL CRYSTAL STRUCTURE OF INTERLEUKIN-19 DEFINES A NEW SUBFAMILYTITL 2 OF HELICAL CYTOKINESREF J.BIOL.CHEM. V. 278 3308 2003REFN ISSN 0021-9258PMID 12403790DOI 10.1074/JBC.M208602200 Variant Set Distributions Mapped Variants
General Structure Information 3h5c SERPINA10 x-ray structure of protein z-protein z inhibitor complex 3.26Å AUTH X.HUANG,A.DEMENTIEV,S.T.OLSON,P.G.GETTINSTITL BASIS FOR THE SPECIFICITY AND ACTIVATION OF THE SERPINTITL 2 PROTEIN Z-DEPENDENT PROTEINASE INHIBITOR (ZPI) AS ANTITL 3 INHIBITOR OF MEMBRANE-ASSOCIATED FACTOR XA.REF J.BIOL.CHEM. V. 285 20399 2010REFN ISSN 0021-9258PMID 20427285DOI 10.1074/JBC.M110.112748 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1jhj ANAPC10 crystal structure of the apc10/doc1 subunit of the human anaphase-promoting complex 1.6Å AUTH K.S.WENDT,H.C.VODERMAIER,U.JACOB,C.GIEFFERS,AUTH 2 M.GMACHL,J.M.PETERS,R.HUBER,P.SONDERMANNTITL CRYSTAL STRUCTURE OF THE APC10/DOC1 SUBUNIT OF THETITL 2 HUMAN ANAPHASE-PROMOTING COMPLEX.REF NAT.STRUCT.BIOL. V. 8 784 2001REFN ISSN 1072-8368PMID 11524682DOI 10.1038/NSB0901-784 Variant Set Distributions Mapped Variants
General Structure Information 1wiz SATB2 solution structure of the first cut domain of kiaa1034 protein -1.0Å AUTH K.INOUE,S.NAMEKI,F.HAYASHI,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST CUT DOMAIN OFTITL 2 KIAA1034 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ae4 UBAP1 the ubap1 subunit of escrt-i interacts with ubiquitin via a novel souba domain 1.65Å AUTH M.AGROMAYOR,N.SOLER,A.CABALLE,T.KUECK,S.M.FREUND,M.D.ALLEN,AUTH 2 M.BYCROFT,O.PERISIC,Y.YE,B.MCDONALD,H.SCHEEL,K.HOFMANN,AUTH 3 S.J.D.NEIL,J.MARTIN-SERRANO,R.L.WILLIAMSTITL THE UBAP1 SUBUNIT OF ESCRT-I INTERACTS WITH UBIQUITIN VIA ATITL 2 SOUBA DOMAIN.REF STRUCTURE V. 20 414 2012REFN ISSN 0969-2126PMID 22405001DOI 10.1016/J.STR.2011.12.013 Variant Set Distributions Mapped Variants
General Structure Information 2jw5 POLL polymerase lambda brct domain -1.0Å AUTH G.A.MUELLER,A.F.MOON,E.F.DEROSE,B.J.DAVIS,AUTH 2 D.A.RAMSDEN,L.C.PEDERSEN,R.E.LONDONTITL POLYMERASE LAMBDA BRCT DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3b1u PADI4 crystal structure of human peptidylarginine deiminase 4 in complex with o-f-amidine 2.1Å AUTH C.P.CAUSEY,J.E.JONES,J.L.SLACK,D.KAMEI,L.E.JONES JR,AUTH 2 V.SUBRAMANIAN,B.KNUCKLEY,P.EBRAHIMI,A.A.CHUMANEVICH,Y.LUO,AUTH 3 H.HASHIMOTO,M.SATO,L.J.HOFSETH,P.R.THOMPSONTITL THE DEVELOPMENT OFTITL 2 N-ALPHA-(2-CARBOXYL)BENZOYL-N(5)-(2-FLUORO-1-IMINOETHYL)-L-TITL 3 ORNITHINE AMIDE (O-F-AMIDINE) ANDTITL 4 N-ALPHA-(2-CARBOXYL)BENZOYL-N(5)-(2-CHLORO-1-IMINOETHYL)-L-TITL 5 ORNITHINE AMIDE (O-CL-AMIDINE) AS SECOND GENERATION PROTEINTITL 6 ARGININE DEIMINASE (PAD) INHIBITORSREF J.MED.CHEM. V. 54 6919 2011REFN ISSN […]