2BYE.A | PLCE1

General Structure Information

PDB ID	2bye
HGNC Gene Label(s)	PLCE1
Structure Name	nmr solution structure of phospholipase c epsilon ra 1 domain
Resolution	-1.0Å
Reference	AUTH T.D.BUNNEY,R.HARRIS,N.L.GANDARILLAS,M.B.JOSEPHS,AUTH 2 S.M.ROE,S.C.SORLI,H.F.PATERSON,F.RODRIGUES-LIMA,AUTH 3 D.ESPOSITO,C.P.PONTING,P.GIERSCHIK,L.H.PEARL,AUTH 4 P.C.DRISCOLL,M.KATANTITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO RASTITL 2 ASSOCIATION DOMAINS OF PHOSPHOLIPASE C EPSILON.REF MOL.CELL V. 21 495 2006REFN ISSN 1097-2765PMID 16483931DOI 10.1016/J.MOLCEL.2006.01.008

Variant Set Distributions

ExAC Variants

Number Of Residues	109
Number Of SNVs	27
Number Of Permutations	13482
Optimal Distance Threshold	12.0
K Statistic	0.179
p-value	0.897

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
10:96073026		E>Q	A:3	(-221.47, -12.42, 109.14)
10:96073057		T>M	A:13	(-245.11, -18.98, 100.81)
10:96073068	rs552752024	V>I	A:17	(-251.24, -12.88, 99.74)
10:96073080	rs371057938	E>Q	A:21	(-250.15, -13.93, 93.42)
10:96073092		V>I	A:25	(-243.21, -16.19, 98.73)
10:96073108	rs377038783 COSM3441869 COSM218286 COSM1159215	G>A	A:30	(-232.39, -9.75, 109.51)
10:96073136		Q>H	A:39	(-244.37, -4.42, 107.35)
10:96076313		N>H	A:44	(-247.50, -2.43, 97.72)
10:96076325		I>V	A:48	(-242.55, -0.15, 100.93)
10:96076335	rs202230448	V>A	A:51	(-254.58, -0.04, 103.54)
10:96076338		T>I	A:52	(-250.85, -1.54, 106.87)
10:96076340	rs374921875	T>P	A:53	(-255.38, -3.89, 108.03)
10:96076343	rs190025280	D>N	A:54	(-256.61, -5.82, 111.45)
10:96076344	rs372611082	D>V	A:54	(-256.61, -5.82, 111.45)
10:96076356	rs373329178	M>K	A:58	(-253.19, -18.72, 111.05)
10:96076359		E>A	A:59	(-249.17, -22.42, 112.01)
10:96076365		K>I	A:61	(-249.42, -27.61, 111.28)
10:96076373		I>V	A:64	(-249.39, -35.81, 110.14)
10:96076377	COSM466112 COSM1135072	S>C	A:65	(-253.03, -38.95, 112.92)
10:96076383		E>G	A:67	(-256.61, -40.27, 106.09)
10:96076405		Q>H	A:74	(-260.63, -29.21, 117.78)
10:96076419		A>V	A:79	(-252.78, -17.44, 115.65)
10:96076424		G>R	A:81	(-248.40, -13.04, 116.46)
10:96076425		G>D	A:81	(-248.40, -13.04, 116.46)
10:96076481		M>V	A:100	(-249.24, -31.46, 106.83)
10:96076483	rs538437231	M>I	A:100	(-249.24, -31.46, 106.83)
10:96076488		R>K	A:102	(-252.00, -24.05, 105.26)
10:96076491	rs375684891	I>T	A:103	(-247.76, -18.85, 106.60)
10:96076502		T>P	A:107	(-258.78, -10.60, 108.56)
10:96076510		Q>H	A:109	(-263.72, -10.70, 111.56)

2BYE.A | PLCE1.

2BYE.A | PLCE1

General Structure Information

Variant Set Distributions

Mapped Variants

[+] ExAC Missense Variants