Assessment of Structural Intolerance and Durability
General Structure Information 3uoa MALT1 crystal structure of the malt1 paracaspase (p21 form) 1.75Å AUTH J.W.YU,P.D.JEFFREY,J.Y.HA,X.YANG,Y.SHITITL CRYSTAL STRUCTURE OF THE MUCOSA-ASSOCIATED LYMPHOID TISSUETITL 2 LYMPHOMA TRANSLOCATION 1 (MALT1) PARACASPASE REGION.REF PROC.NATL.ACAD.SCI.USA V. 108 21004 2011REFN ISSN 0027-8424PMID 22158899DOI 10.1073/PNAS.1111708108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4cos ZMYND8 crystal structure of the phd-bromo-pwwp cassette of human prkcbp1 1.67Å AUTH P.FILIPPAKOPOULOSTITL CRYSTAL STRUCTURE OF THE PHD-BROMO-PWWP CASSETTE OF HUMANTITL 2 PRKCBP1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2m6n FBXO5 3d solution structure of emi1 (early mitotic inhibitor 1) -1.0Å AUTH J.J.FRYE,N.G.BROWN,G.PETZOLD,E.R.WATSON,C.R.GRACE,A.NOURSE,AUTH 2 M.A.JARVIS,R.W.KRIWACKI,J.M.PETERS,H.STARK,B.A.SCHULMANTITL ELECTRON MICROSCOPY STRUCTURE OF HUMAN APC/C(CDH1)-EMI1TITL 2 REVEALS MULTIMODAL MECHANISM OF E3 LIGASE SHUTDOWN.REF NAT.STRUCT.MOL.BIOL. V. 20 827 2013REFN ISSN 1545-9993PMID 23708605DOI 10.1038/NSMB.2593 Variant Set Distributions Mapped Variants
General Structure Information 3zrh ZRANB1 crystal structure of the lys29, lys33-linkage-specific trabid otu deubiquitinase domain reveals an ankyrin-repeat ubiquitin binding domain (ankubd) 2.23Å AUTH J.D.F.LICCHESI,J.MIESZCZANEK,T.E.T.MEVISSEN,T.J.RUTHERFORD,AUTH 2 M.AKUTSU,S.VIRDEE,F.E.OUALID,J.W.CHIN,H.OVAA,M.BIENZ,AUTH 3 D.KOMANDERTITL AN ANKYRIN-REPEAT UBIQUITIN-BINDING DOMAIN DETERMINESTITL 2 TRABIDS SPECIFICITY FOR ATYPICAL UBIQUITIN CHAINS.REF NAT.STRUCT.MOL.BIOL. V. 19 62 2011REFN ISSN 1545-9993PMID 22157957DOI 10.1038/NSMB.2169 Variant Set Distributions Ripley’s K […]
General Structure Information 1z0i RAB21 gdp-bound rab21 gtpase 2.33Å AUTH S.EATHIRAJ,X.PAN,C.RITACCO,D.G.LAMBRIGHTTITL STRUCTURAL BASIS OF FAMILY-WIDE RAB GTPASETITL 2 RECOGNITION BY RABENOSYN-5.REF NATURE V. 436 415 2005REFN ISSN 0028-0836PMID 16034420DOI 10.1038/NATURE03798 Variant Set Distributions Mapped Variants
General Structure Information 4lg8 PRPF19 crystal structure of prpf19 wd40 repeats 1.89Å AUTH C.XU,W.TEMPEL,H.HE,E.DOBROVETSKY,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,J.MIN,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF PRPF19 WD40 REPEATSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lgg CECR1 crystal structure of human adenosine deaminase growth factor, adenosine deaminase type 2 (ada2) complexed with transition state analogue, coformycin 2.5Å AUTH A.V.ZAVIALOV,X.YU,D.SPILLMANN,G.LAUVAU,A.V.ZAVIALOVTITL STRUCTURAL BASIS FOR THE GROWTH FACTOR ACTIVITY OF HUMANTITL 2 ADENOSINE DEAMINASE ADA2.REF J.BIOL.CHEM. V. 285 12367 2010REFN ISSN 0021-9258PMID 20147294DOI 10.1074/JBC.M109.083527 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2x7f TNIK crystal structure of the kinase domain of human traf2- and nck-interacting kinase with wee1chk1 inhibitor 2.8Å AUTH M.VOLLMAR,I.ALFANO,B.SHRESTHA,J.BRAY,J.R.C.MUNIZ,A.ROOS,AUTH 2 P.FILIPPAKOPOULOS,N.BURGESS-BROWN,E.UGOCHUKWU,O.GILEADI,AUTH 3 C.PHILLIPS,P.MAHAJAN,A.C.W.PIKE,O.FEDOROV,A.CHAIKUAD,AUTH 4 F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,AUTH 5 S.KNAPPTITL CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF HUMAN TRAF2- ANDTITL 2 NCK-INTERACTING KINASE WITH WEE1CHK1 INHIBITORREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s […]
General Structure Information 1fo3 MAN1B1 crystal structure of human class i alpha1,2-mannosidase in complex with kifunensine 1.75Å AUTH F.VALLEE,K.KARAVEG,A.HERSCOVICS,K.W.MOREMEN,AUTH 2 P.L.HOWELLTITL STRUCTURAL BASIS FOR CATALYSIS AND INHIBITION OFTITL 2 N-GLYCAN PROCESSING CLASS I ALPHA 1,2-MANNOSIDASES.REF J.BIOL.CHEM. V. 275 41287 2000REFN ISSN 0021-9258PMID 10995765DOI 10.1074/JBC.M006927200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2os6 ARHGEF12 solution structure of larg pdz domain in complex with c- terminal octa-peptide of plexin b1 -1.0Å AUTH J.LIU,H.HUANG,Y.YANGTITL SOLUTION STRUCTURE OF THE LARG PDZ DOMAIN INTITL 2 COMPLEX WITH C-TERMINAL PEPTIDE OF PLEXIN B1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants