Assessment of Structural Intolerance and Durability
General Structure Information 1y8r SAE1 sumo e1 activating enzyme sae1-sae2-sumo1-mg-atp complex 2.75Å AUTH L.M.LOIS,C.D.LIMATITL STRUCTURES OF THE SUMO E1 PROVIDE MECHANISTICTITL 2 INSIGHTS INTO SUMO ACTIVATION AND E2 RECRUITMENTTITL 3 TO E1REF EMBO J. V. 24 439 2005REFN ISSN 0261-4189PMID 15660128DOI 10.1038/SJ.EMBOJ.7600552 Variant Set Distributions Mapped Variants
General Structure Information 4afl ING4 the crystal structure of the ing4 dimerization domain reveals the functional organization of the ing family of chromatin binding proteins. 2.28Å AUTH S.CULURGIONI,I.G.MUNOZ,A.MORENO,A.PALACIOS,M.VILLATE,AUTH 2 I.PALMERO,G.MONTOYA,F.J.BLANCOTITL CRYSTAL STRUCTURE OF INHIBITOR OF GROWTH 4 (ING4)TITL 2 DIMERIZATION DOMAIN REVEALS FUNCTIONAL ORGANIZATION OF INGTITL 3 FAMILY OF CHROMATIN-BINDING PROTEINS.REF J.BIOL.CHEM. V. 287 10876 […]
General Structure Information 2boa CPA4 human procarboxypeptidase a4. 2.2Å AUTH R.GARCIA-CASTELLANOS,R.BONET-FIGUEREDO,I.PALLARES,AUTH 2 S.VENTURA,F.X.AVILES,J.VENDRELL,F.X.GOMIS-RUTHTITL DETAILED MOLECULAR COMPARISON BETWEEN THETITL 2 INHIBITION MODE OF A/B-TYPE CARBOXYPEPTIDASES INTITL 3 THE ZYMOGEN STATE AND BY THE ENDOGENOUS INHIBITORTITL 4 LATEXIN.REF CELL.MOL.LIFE SCI. V. 62 1996 2005REFN ISSN 1420-682XPMID 16091843DOI 10.1007/S00018-005-5174-4 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1deu CTSZ crystal structure of human procathepsin x: a cysteine protease with the proregion covalently linked to the active site cysteine 1.7Å AUTH J.SIVARAMAN,D.K.NAGLER,R.ZHANG,R.MENARD,M.CYGLERTITL CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN X: A CYSTEINETITL 2 PROTEASE WITH THE PROREGION COVALENTLY LINKED TO THE ACTIVETITL 3 SITE CYSTEINE.REF J.MOL.BIOL. V. 295 939 2000REFN ISSN 0022-2836PMID […]
General Structure Information 2rjq ADAMTS5 crystal structure of adamts5 with inhibitor bound 2.6Å AUTH L.MOSYAK,K.GEORGIADIS,T.SHANE,K.SVENSON,T.HEBERT,T.MCDONAGH,AUTH 2 S.MACKIE,S.OLLAND,L.LIN,X.ZHONG,R.KRIZ,E.L.REIFENBERG,AUTH 3 L.A.COLLINS-RACIE,C.CORCORAN,B.FREEMAN,R.ZOLLNER,T.MARVELL,AUTH 4 M.VERA,P.E.SUM,E.R.LAVALLIE,M.STAHL,W.SOMERSTITL CRYSTAL STRUCTURES OF THE TWO MAJOR AGGRECAN DEGRADINGTITL 2 ENZYMES, ADAMTS4 AND ADAMTS5.REF PROTEIN SCI. V. 17 16 2008REFN ISSN 0961-8368PMID 18042673DOI 10.1110/PS.073287008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3qc8 FAF1 crystal structure of faf1 ubx domain in complex with p97/vcp n domain reveals the conserved fcisp touch-turn motif of ubx domain suffering conformational change 2.2Å AUTH K.H.KIM,W.KANG,S.W.SUH,J.K.YANGTITL CRYSTAL STRUCTURE OF FAF1 UBX DOMAIN IN COMPLEX WITH P97/VCPTITL 2 N DOMAIN REVEALS A CONFORMATIONAL CHANGE IN THE CONSERVEDTITL 3 FCISP TOUCH-TURN […]
General Structure Information 1sgo GSKIP nmr structure of the human c14orf129 gene product, hspc210. northeast structural genomics target hr969. -1.0Å AUTH T.A.RAMELOT,J.R.CORT,R.XIAO,L.-Y.SHIH,L.-C.MA,AUTH 2 T.B.ACTON,G.T.MONTELIONE,M.A.KENNEDYTITL NMR STRUCTURE OF THE HUMAN C14ORF129 GENE PRODUCT,TITL 2 HSPC210. NORTHEAST STRUCTURAL GENOMICS TARGETTITL 3 HR969.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1rz4 EIF3K crystal structure of human eif3k 2.1Å AUTH Z.WEI,P.ZHANG,Z.ZHOU,Z.CHENG,M.WAN,W.GONGTITL CRYSTAL STRUCTURE OF HUMAN EIF3K, THE FIRST STRUCTURE OFTITL 2 EIF3 SUBUNITSREF J.BIOL.CHEM. V. 279 34983 2004REFN ISSN 0021-9258PMID 15180986DOI 10.1074/JBC.M405158200 Variant Set Distributions Mapped Variants
General Structure Information 4dxt SUN2 human sun2 (aa 522-717) 2.22Å AUTH B.A.SOSA,A.ROTHBALLER,U.KUTAY,T.U.SCHWARTZTITL LINC COMPLEXES FORM BY BINDING OF THREE KASH PEPTIDES TOTITL 2 DOMAIN INTERFACES OF TRIMERIC SUN PROTEINS.REF CELL(CAMBRIDGE,MASS.) V. 149 1035 2012REFN ISSN 0092-8674PMID 22632968DOI 10.1016/J.CELL.2012.03.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2oxc DDX20 human dead-box rna helicase ddx20, dead domain in complex with adp 1.3Å AUTH T.KARLBERG,D.OGG,C.H ARROWSMITH,H.BERGLUND,AUTH 2 R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,B.M.HALLBERG,AUTH 4 M.HAMMARSTROM,M.HOGBOM,I.JOHANSSON,T.KOTENYOVA,AUTH 5 L.LEHTIO,M.MOCHE,P.NORDLUND,T.NYMAN,C.PERSSON,AUTH 6 J.SAGEMARK,P.STENMARK,M.SUNDSTROM,A.G.THORSELL,AUTH 7 S.VAN DEN BERG,J.WEIGELT,L.HOLMBERG-SCHIAVONETITL HUMAN DEAD-BOX RNA HELICASE DDX20REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]