Assessment of Structural Intolerance and Durability
General Structure Information 1j0w DOK5 crystal structure analysis of the dok-5 ptb domain 2.5Å AUTH N.SHI,Y.DING,B.Q.QIANG,J.G.YUAN,Z.H.RAOTITL CRYSTAL STRUCTURE ANALYSIS OF THE DOK-5 PTB DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ss6 NSFL1C solution structure of sep domain from human p47 -1.0Å AUTH M.SOUKENIK,A.DIEHL,M.LEIDERT,V.SIEVERT,K.BUESSOW,AUTH 2 D.LEITNER,D.LABUDDE,L.J.BALL,A.LECHNER,D.K.NAGLER,AUTH 3 H.OSCHKINATTITL THE SEP DOMAIN OF P47 ACTS AS A REVERSIBLETITL 2 COMPETITIVE INHIBITOR OF CATHEPSIN LREF FEBS LETT. V. 576 358 2004REFN ISSN 0014-5793PMID 15498563DOI 10.1016/J.FEBSLET.2004.09.037 Variant Set Distributions Mapped Variants
General Structure Information 2xph SENP1 crystal structure of human senp1 with the bound cobalt 2.4Å AUTH V.RIMSA,T.EADSFORTH,R.T.HAY,W.N.HUNTERTITL THE ROLE OF CO2+ IN THE CRYSTALLIZATION OF HUMAN SENP1 ANDTITL 2 COMMENTS ON THE LIMITATIONS OF AUTOMATED REFINEMENTTITL 3 PROTOCOLSREF ACTA CRYSTALLOGR.,SECT.F V. 67 442 2011REFN ISSN 1744-3091PMID 21505236DOI 10.1107/S1744309111005835 Variant Set Distributions Mapped Variants
General Structure Information 1ln3 PCTP structure of human phosphatidylcholine transfer protein in complex with palmitoyl-linoleoyl phosphatidylcholine (seleno-met protein) 2.9Å AUTH S.L.RODERICK,W.W.CHAN,D.S.AGATE,L.R.OLSEN,AUTH 2 M.W.VETTING,K.R.RAJASHANKAR,D.E.COHENTITL STRUCTURE OF HUMAN PHOSPHATIDYLCHOLINE TRANSFERTITL 2 PROTEIN IN COMPLEX WITH ITS LIGAND.REF NAT.STRUCT.BIOL. V. 9 507 2002REFN ISSN 1072-8368PMID 12055623 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2ly9 ZHX1 solution nmr structure of homeobox 2 domain from human zhx1 repressor, northeast structural genomics consortium (nesg) target hr7907f -1.0Å AUTH X.XU,A.ELETSKY,J.L.MILLS,S.V.S.R.K.PULAVARTI,D.LEE,E.KOHAN,AUTH 2 H.JANJUA,R.XIAO,T.B.ACTON,J.K.EVERETT,G.T.MONTELIONE,AUTH 3 T.SZYPERSKITITL SOLUTION NMR STRUCTURE OF HOMEOBOX 2 DOMAIN FROM HUMAN ZHX1TITL 2 REPRESSOR, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG)TITL 3 TARGET HR7907FREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 1×51 MUTYH solution structure of the nudix domain from human a/g- specific adenine dna glycosylase alpha-3 splice isoform -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE NUDIX DOMAIN FROM HUMANTITL 2 A/G-SPECIFIC ADENINE DNA GLYCOSYLASE ALPHA-3TITL 3 SPLICE ISOFORMREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2rr3 VAPA solution structure of the complex between human vap-a msp domain and human osbp ffat motif -1.0Å AUTH K.FURUITA,J.JEE,H.FUKADA,M.MISHIMA,C.KOJIMATITL ELECTROSTATIC INTERACTION BETWEEN OXYSTEROL-BINDING PROTEINTITL 2 AND VAMP-ASSOCIATED PROTEIN A REVEALED BY NMR ANDTITL 3 MUTAGENESIS STUDIESREF J.BIOL.CHEM. V. 285 12961 2010REFN ISSN 0021-9258PMID 20178991DOI 10.1074/JBC.M109.082602 Variant Set Distributions Mapped Variants
General Structure Information 4i2x SIRPG crystal structure of signal regulatory protein gamma (sirp-gamma) in complex with fabox117 2.48Å AUTH J.E.NETTLESHIP,J.REN,D.J.SCOTT,N.RAHMAN,D.HATHERLEY,Y.ZHAO,AUTH 2 D.I.STUART,A.N.BARCLAY,R.J.OWENSTITL CRYSTAL STRUCTURE OF SIGNAL REGULATORY PROTEIN GAMMA (SIRPTITL 2 GAMMA) IN COMPLEX WITH AN ANTIBODY FAB FRAGMENT.REF BMC STRUCT.BIOL. V. 13 13 2013REFN ESSN 1472-6807PMID 23826770DOI 10.1186/1472-6807-13-13 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2ej8 APPL1 crystal structure of appl1 ptb domain at 1.8a 1.84Å AUTH H.TANABE,T.HOSAKA,K.MURAYAMA,T.TERADA,M.SHIROUZU,AUTH 2 S.YOKOYAMATITL CRYSTAL STRUCTURE OF APPL1 PTB DOMAIN AT 1.8AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2xd7 H2AFY2 crystal structure of the macro domain of human core histone h2a 2.09Å AUTH M.VOLLMAR,C.PHILLIPPS,E.P.CARPENTER,J.R.C.MUNIZ,AUTH 2 T.KROJER,E.UGOCHUKWU,F.VON DELFT,C.BOUNTRA,AUTH 3 C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,O.GILEADITITL CRYSTAL STRUCTURE OF THE MACRO DOMAIN OF HUMANTITL 2 CORE HISTONE H2AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants