Assessment of Structural Intolerance and Durability
General Structure Information 2daw RWDD2A solution structure of the rwd domain of human rwd omain containing protein 2 -1.0Å AUTH M.YONEYAMA,T.KIGAWA,M.SATO,N.TOCHIO,S.KOSHIBA,AUTH 2 M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RWD DOMAIN OF HUMAN RWDTITL 2 OMAIN CONTAINING PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1zs9 ENOPH1 crystal structure of human enolase-phosphatase e1 1.7Å AUTH H.WANG,H.PANG,M.BARTLAM,Z.RAOTITL CRYSTAL STRUCTURE OF HUMAN E1 ENZYME AND ITSTITL 2 COMPLEX WITH A SUBSTRATE ANALOG REVEALS THETITL 3 MECHANISM OF ITS PHOSPHATASE/ENOLASEREF J.MOL.BIOL. V. 348 917 2005REFN ISSN 0022-2836PMID 15843022DOI 10.1016/J.JMB.2005.01.072 Variant Set Distributions Mapped Variants
General Structure Information 2dzm FAF1 solution structure of the ubiquitin-like domain in human fas-associated factor 1 (hfaf1) -1.0Å AUTH C.ZHAO,M.SATO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE UBIQUITIN-LIKE DOMAIN INTITL 2 HUMAN FAS-ASSOCIATED FACTOR 1 (HFAF1)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ec1 NUP50 solution structure of the ranbd1 domain from human nucleoporin 50 kda -1.0Å AUTH H.P.ZHANG,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RANBD1 DOMAIN FROM HUMANTITL 2 NUCLEOPORIN 50 KDAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1wi1 CADPS solution structure of the ph domain of human calcium- dependent activator protein for secretion (caps) -1.0Å AUTH M.YONEYAMA,K.IZUMI,M.YOSHIDA,N.TOCHIO,S.KOSHIBA,AUTH 2 M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF HUMANTITL 2 CALCIUM-DEPENDENT ACTIVATOR PROTEIN FOR SECRETIONTITL 3 (CAPS)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4fnw ALK crystal structure of the apo f1174l anaplastic lymphoma kinase catalytic domain 1.75Å AUTH L.F.EPSTEIN,H.CHEN,R.EMKEY,D.A.WHITTINGTONTITL THE R1275Q NEUROBLASTOMA MUTANT AND CERTAIN ATP-COMPETITIVETITL 2 INHIBITORS STABILIZE ALTERNATIVE ACTIVATION LOOPTITL 3 CONFORMATIONS OF ANAPLASTIC LYMPHOMA KINASE.REF J.BIOL.CHEM. V. 287 37447 2012REFN ISSN 0021-9258PMID 22932897DOI 10.1074/JBC.M112.391425 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4f9b DBF4 human cdc7 kinase in complex with dbf4 and pha767491 2.5Å AUTH S.HUGHES,F.ELUSTONDO,A.DI FONZO,F.G.LEROUX,A.C.WONG,AUTH 2 A.P.SNIJDERS,S.J.MATTHEWS,P.CHEREPANOVTITL CRYSTAL STRUCTURE OF HUMAN CDC7 KINASE IN COMPLEX WITH ITSTITL 2 ACTIVATOR DBF4.REF NAT.STRUCT.MOL.BIOL. V. 19 1101 2012REFN ISSN 1545-9993PMID 23064647DOI 10.1038/NSMB.2404 Variant Set Distributions Mapped Variants
General Structure Information 3wh2 CLEC4E human mincle in complex with citrate 1.3Å AUTH A.FURUKAWA,J.KAMISHIKIRYO,D.MORI,K.TOYONAGA,Y.OKABE,A.TOJI,AUTH 2 R.KANDA,Y.MIYAKE,T.OSE,S.YAMASAKI,K.MAENAKATITL STRUCTURAL ANALYSIS FOR GLYCOLIPID RECOGNITION BY THE C-TYPETITL 2 LECTINS MINCLE AND MCLREF PROC.NATL.ACAD.SCI.USA V. 110 17438 2013REFN ISSN 0027-8424PMID 24101491DOI 10.1073/PNAS.1312649110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3in5 POLK structure of human dna polymerase kappa inserting datp opposite an 8-oxog dna lesion 3.2Å AUTH R.VASQUEZ-DEL CARPIO,T.D.SILVERSTEIN,S.LONE,AUTH 2 M.K.SWAN,J.R.CHOUDHURY,R.E.JOHNSON,S.PRAKASH,AUTH 3 L.PRAKASH,A.K.AGGARWALTITL STRUCTURE OF HUMAN DNA POLYMERASE KAPPA INSERTINGTITL 2 DATP OPPOSITE AN 8-OXOG DNA LESIONREF PLOS ONE V. 4 E5766 2009REFN ESSN 1932-6203PMID 19492058DOI 10.1371/JOURNAL.PONE.0005766 Variant Set Distributions Pathogenic Proximity […]
General Structure Information 1d4b CIDEB cide-n domain of human cide-b -1.0Å AUTH A.A.LUGOVSKOY,P.ZHOU,J.J.CHOU,J.S.MCCARTY,P.LI,AUTH 2 G.WAGNERTITL SOLUTION STRUCTURE OF THE CIDE-N DOMAIN OF CIDE-BTITL 2 AND A MODEL FOR CIDE-N/CIDE-N INTERACTIONS IN THETITL 3 DNA FRAGMENTATION PATHWAY OF APOPTOSIS.REF CELL(CAMBRIDGE,MASS.) V. 99 747 1999REFN ISSN 0092-8674PMID 10619428DOI 10.1016/S0092-8674(00)81672-4 Variant Set Distributions Mapped Variants