Assessment of Structural Intolerance and Durability
General Structure Information 4irq B4GALT7 crystal structure of catalytic domain of human beta1, 4galactosyltransferase 7 in closed conformation in complex with manganese and udp 2.3Å AUTH Y.TSUTSUI,B.RAMAKRISHNAN,P.K.QASBATITL CRYSTAL STRUCTURES OF BETA-1,4-GALACTOSYLTRANSFERASE 7TITL 2 ENZYME REVEAL CONFORMATIONAL CHANGES AND SUBSTRATE BINDING.REF J.BIOL.CHEM. V. 288 31963 2013REFN ISSN 0021-9258PMID 24052259DOI 10.1074/JBC.M113.509984 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2cq1 PTBP2 solution structure of rna binding domain in ptb-like protein l -1.0Å AUTH K.TSUDA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF RNA BINDING DOMAIN INTITL 2 PTB-LIKE PROTEIN LREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3b94 TNFSF18 crystal structure of human gitrl 2.5Å AUTH X.M.SONG,Z.C.ZHOU,M.I.GREENETITL CRYSTAL STRUCTURE OF HUMAN GITRLREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3vro CBLC crystal structure of the tyrosine kinase binding domain of cbl-c in complex with phospho-src peptide 1.8Å AUTH K.TAKESHITA,T.TEZUKA,Y.ISOZAKI,E.YAMASHITA,M.SUZUKI,M.KIM,AUTH 2 Y.YAMANASHI,T.YAMAMOTO,A.NAKAGAWATITL STRUCTURAL FLEXIBILITY REGULATES PHOSPHOPEPTIDE-BINDINGTITL 2 ACTIVITY OF THE TYROSINE KINASE BINDING DOMAIN OF CBL-C.REF J.BIOCHEM. V. 152 487 2012REFN ISSN 0021-924XPMID 22888118DOI 10.1093/JB/MVS085 Variant Set Distributions Mapped Variants
General Structure Information 3ffl ANAPC7 crystal structure of the n-terminal domain of anaphase-promoting complex subunit 7 2.5Å AUTH D.HAN,K.KIM,Y.KIM,Y.KANG,Y.KIMTITL CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OFTITL 2 ANAPHASE-PROMOTING COMPLEX SUBUNIT 7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3pfs BRPF3 pwwp domain of human bromodomain and phd finger-containing protein 3 1.9Å AUTH H.WU,H.ZENG,R.LAM,W.TEMPEL,M.F.AMAYA,C.XU,L.DOMBROVSKI,AUTH 2 W.QIU,Y.WANG,J.MINTITL STRUCTURAL AND HISTONE BINDING ABILITY CHARACTERIZATIONS OFTITL 2 HUMAN PWWP DOMAINS.REF PLOS ONE V. 6 18919 2011REFN ESSN 1932-6203PMID 21720545DOI 10.1371/JOURNAL.PONE.0018919 Variant Set Distributions Mapped Variants
General Structure Information 2f57 PAK7 crystal structure of the human p21-activated kinase 5 1.8Å AUTH J.ESWARAN,W.H.LEE,J.E.DEBRECZENI,P.FILIPPAKOPOULOS,AUTH 2 A.TURNBULL,O.FEDOROV,S.W.DEACON,J.R.PETERSON,S.KNAPPTITL CRYSTAL STRUCTURES OF THE P21-ACTIVATED KINASES PAK4, PAK5,TITL 2 AND PAK6 REVEAL CATALYTIC DOMAIN PLASTICITY OF ACTIVE GROUPTITL 3 II PAKS.REF STRUCTURE V. 15 201 2007REFN ISSN 0969-2126PMID 17292838DOI 10.1016/J.STR.2007.01.001 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2xmq NDRG2 crystal structure of human ndrg2 protein provides insight into its role as a tumor suppressor 2.81Å AUTH J.HWANG,Y.KIM,H.B.KANG,L.JAROSZEWSKI,A.DEACON,AUTH 2 H.LEE,W.C.CHOI,K.J.KIM,C.H.KIM,B.S.KANG,J.O.LEE,AUTH 3 T.K.OH,J.W.KIM,I.A.WILSON,M.H.KIMTITL CRYSTAL STRUCTURE OF HUMAN NDRG2 PROTEIN PROVIDESTITL 2 INSIGHT INTO ITS ROLE AS A TUMOR SUPPRESSOR.REF J.BIOL.CHEM. V. 286 12450 2011REFN ISSN 0021-9258PMID 21247902DOI 10.1074/JBC.M110.170803 Variant Set Distributions […]
General Structure Information 1wjp ZBTB21 solution structure of zf-c2h2 domains from human zinc finger protein 295 -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,K.SAITO,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF ZF-C2H2 DOMAINS FROM HUMANTITL 2 ZINC FINGER PROTEIN 295REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1mhq GGA2 crystal structure of human gga2 vhs domain 2.2Å AUTH G.ZHU,X.HE,S.TERZYAN,P.ZHAI,J.TANG,X.C.ZHANGTITL CRYSTAL STRUCTURE OF GGA2 VHS DOMAIN AND ITSTITL 2 IMPLICATION IN PLASTICITY IN THE LIGAND BINDINGTITL 3 POCKETREF FEBS LETT. V. 537 171 2003REFN ISSN 0014-5793PMID 12606052DOI 10.1016/S0014-5793(03)00095-4 Variant Set Distributions Mapped Variants