Assessment of Structural Intolerance and Durability
General Structure Information 1×61 TRIP6 solution structure of the first lim domain of thyroid receptor interacting protein 6 (trip6) -1.0Å AUTH X.R.QIN,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST LIM DOMAIN OFTITL 2 THYROID RECEPTOR INTERACTING PROTEIN 6 (TRIP6)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1×61 TRIP6 solution structure of the first lim domain of thyroid receptor interacting protein 6 (trip6) -1.0Å AUTH X.R.QIN,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST LIM DOMAIN OFTITL 2 THYROID RECEPTOR INTERACTING PROTEIN 6 (TRIP6)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lk2 TGIF1 solution nmr structure of homeobox domain (171-248) of human homeobox protein tgif1, northeast structural genomics consortium target hr4411b -1.0Å AUTH Y.YANG,T.A.RAMELOT,J.R.CORT,R.SHASTRY,C.CICCOSANTI,AUTH 2 K.HAMILTON,T.B.ACTON,R.XIAO,J.K.EVERETT,G.T.MONTELIONE,AUTH 3 M.A.KENNEDYTITL SOLUTION NMR STRUCTURE OF HOMEOBOX DOMAIN (171-248) OF HUMANTITL 2 HOMEOBOX PROTEIN TGIF1, NORTHEAST STRUCTURAL GENOMICSTITL 3 CONSORTIUM TARGET HR4411B.REF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 1i3n GALE molecular basis for severe epimerase-deficiency galactosemia: x-ray structure of the human v94m- substituted udp-galactose 4-epimerase 1.5Å AUTH J.B.THODEN,T.M.WOHLERS,J.L.FRIDOVICH-KEIL,AUTH 2 H.M.HOLDENTITL MOLECULAR BASIS FOR SEVERE EPIMERASE DEFICIENCYTITL 2 GALACTOSEMIA. X-RAY STRUCTURE OF THE HUMANTITL 3 V94M-SUBSTITUTED UDP-GALACTOSE 4-EPIMERASE.REF J.BIOL.CHEM. V. 276 20617 2001REFN ISSN 0021-9258PMID 11279193DOI 10.1074/JBC.M101304200 Variant Set Distributions Pathogenic […]
General Structure Information 2cur FHL1 solution structure of skeletal muscle lim-protein 1 -1.0Å AUTH T.N.NIRAULA,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF SKELETAL MUSCLE LIM-PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4b95 TCEB1 pvhl-elob-elob-elocc complex_(2s,4r)-1-(2-chlorophenyl)carbonyl-n-[ (4-chlorophenyl)methyl]-4-oxidanyl-pyrrolidine-2-carboxamide bound 2.8Å AUTH D.L.BUCKLEY,J.L.GUSTAFSON,I.VAN MOLLE,A.G.ROTH,H.S.TAE,AUTH 2 P.C.GAREISS,W.L.JORGENSEN,A.CIULLI,C.M.CREWSTITL SMALL-MOLECULE INHIBITORS OF THE INTERACTION BETWEEN THE E3TITL 2 LIGASE VHL AND HIF1ALPHAREF ANGEW.CHEM.INT.ED.ENGL. V. 51 11463 2012REFN ISSN 1433-7851PMID 23065727DOI 10.1002/ANIE.201206231 Variant Set Distributions Mapped Variants
General Structure Information 4b95 TCEB1 pvhl-elob-elob-elocc complex_(2s,4r)-1-(2-chlorophenyl)carbonyl-n-[ (4-chlorophenyl)methyl]-4-oxidanyl-pyrrolidine-2-carboxamide bound 2.8Å AUTH D.L.BUCKLEY,J.L.GUSTAFSON,I.VAN MOLLE,A.G.ROTH,H.S.TAE,AUTH 2 P.C.GAREISS,W.L.JORGENSEN,A.CIULLI,C.M.CREWSTITL SMALL-MOLECULE INHIBITORS OF THE INTERACTION BETWEEN THE E3TITL 2 LIGASE VHL AND HIF1ALPHAREF ANGEW.CHEM.INT.ED.ENGL. V. 51 11463 2012REFN ISSN 1433-7851PMID 23065727DOI 10.1002/ANIE.201206231 Variant Set Distributions Mapped Variants
General Structure Information 3dsh IRF5 crystal structure of dimeric interferon regulatory factor 5 (irf-5) transactivation domain 2.0Å AUTH W.CHEN,S.S.LAM,H.SRINATH,Z.JIANG,J.J.CORREIA,C.A.SCHIFFER,AUTH 2 K.A.FITZGERALD,K.LIN,W.E.ROYERTITL INSIGHTS INTO INTERFERON REGULATORY FACTOR ACTIVATION FROMTITL 2 THE CRYSTAL STRUCTURE OF DIMERIC IRF5.REF NAT.STRUCT.MOL.BIOL. V. 15 1213 2008REFN ISSN 1545-9993PMID 18836453DOI 10.1038/NSMB.1496 Variant Set Distributions Mapped Variants
General Structure Information 4dck SCN5A crystal structure of the c-terminus of voltage-gated sodium channel in complex with fgf13 and cam 2.2Å AUTH C.WANG,B.C.CHUNG,H.YAN,S.Y.LEE,G.S.PITTTITL CRYSTAL STRUCTURE OF THE TERNARY COMPLEX OF A NAV C-TERMINALTITL 2 DOMAIN, A FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR, ANDTITL 3 CALMODULIN.REF STRUCTURE V. 20 1167 2012REFN ISSN 0969-2126PMID 22705208DOI 10.1016/J.STR.2012.05.001 Variant Set […]
General Structure Information 4dck SCN5A crystal structure of the c-terminus of voltage-gated sodium channel in complex with fgf13 and cam 2.2Å AUTH C.WANG,B.C.CHUNG,H.YAN,S.Y.LEE,G.S.PITTTITL CRYSTAL STRUCTURE OF THE TERNARY COMPLEX OF A NAV C-TERMINALTITL 2 DOMAIN, A FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR, ANDTITL 3 CALMODULIN.REF STRUCTURE V. 20 1167 2012REFN ISSN 0969-2126PMID 22705208DOI 10.1016/J.STR.2012.05.001 Variant Set […]