Assessment of Structural Intolerance and Durability
General Structure Information 2d9d BAG5 solution structure of the bag domain (275-350) of bag-family molecular chaperone regulator-5 -1.0Å AUTH A.ARAKAWA,N.HANDA,N.OHSAWA,M.SHIDA,T.KIGAWA,AUTH 2 F.HAYASHI,M.SHIROUZU,S.YOKOYAMATITL THE C-TERMINAL BAG DOMAIN OF BAG5 INDUCESTITL 2 CONFORMATIONAL CHANGES OF THE HSP70TITL 3 NUCLEOTIDE-BINDING DOMAIN FOR ADP-ATP EXCHANGEREF STRUCTURE V. 18 309 2010REFN ISSN 0969-2126PMID 20223214DOI 10.1016/J.STR.2010.01.004 Variant Set Distributions Mapped Variants
General Structure Information 3q2g ADAMTS1 adamts1 in complex with a novel n-hydroxyformamide inhibitors 2.3Å AUTH C.DE SAVI,A.PAPE,J.G.CUMMING,A.TING,P.D.SMITH,J.N.BURROWS,AUTH 2 M.MILLS,C.DAVIES,S.LAMONT,D.MILNE,C.COOK,P.MOORE,Y.SAWYER,AUTH 3 S.GERHARDTTITL THE DESIGN AND SYNTHESIS OF NOVEL N-HYDROXYFORMAMIDETITL 2 INHIBITORS OF ADAM-TS4 FOR THE TREATMENT OF OSTEOARTHRITISREF BIOORG.MED.CHEM.LETT. V. 21 1376 2011REFN ISSN 0960-894XPMID 21300546DOI 10.1016/J.BMCL.2011.01.036 Variant Set Distributions Mapped Variants
General Structure Information 3maz STAP1 crystal structure of the human brdg1/stap-1 sh2 domain in complex with the ntal ptyr136 peptide 1.9Å AUTH T.KANEKO,H.HUANG,B.ZHAO,L.LI,H.LIU,C.K.VOSS,C.WU,AUTH 2 M.R.SCHILLER,S.S.LITITL LOOPS GOVERN SH2 DOMAIN SPECIFICITY BY CONTROLLING ACCESSTITL 2 TO BINDING POCKETS.REF SCI.SIGNAL. V. 3 RA34 2010REFN ESSN 1937-9145PMID 20442417DOI 10.1126/SCISIGNAL.2000796 Variant Set Distributions Mapped Variants
General Structure Information 3ose MARK1 structure of the kinase associated domain 1 (ka1) from mark1 kinase 1.7Å AUTH K.MORAVCEVIC,J.M.MENDROLA,K.R.SCHMITZ,Y.H.WANG,D.SLOCHOWER,AUTH 2 P.A.JANMEY,M.A.LEMMONTITL KINASE ASSOCIATED-1 DOMAINS DRIVE MARK/PAR1 KINASES TOTITL 2 MEMBRANE TARGETS BY BINDING ACIDIC PHOSPHOLIPIDS.REF CELL(CAMBRIDGE,MASS.) V. 143 966 2010REFN ISSN 0092-8674PMID 21145462DOI 10.1016/J.CELL.2010.11.028 Variant Set Distributions Mapped Variants
General Structure Information 2b1u CALML5 solution structure of calmodulin-like skin protein c terminal domain -1.0Å AUTH E.BABINI,I.BERTINI,F.CAPOZZI,E.CHIRIVINO,C.LUCHINATTITL A STRUCTURAL AND DYNAMIC CHARACTERIZATION OF THETITL 2 EF-HAND PROTEIN CLSP.REF STRUCTURE V. 14 1029 2006REFN ISSN 0969-2126PMID 16765896DOI 10.1016/J.STR.2006.04.004 Variant Set Distributions Mapped Variants
General Structure Information 1v83 B3GAT1 crystal structure of human glcat-p in complex with udp and mn2+ 1.9Å AUTH S.KAKUDA,T.SHIBA,M.ISHIGURO,H.TAGAWA,S.OKA,AUTH 2 Y.KAJIHARA,T.KAWASAKI,S.WAKATSUKI,R.KATOTITL STRUCTURAL BASIS FOR ACCEPTOR SUBSTRATETITL 2 RECOGNITION OF A HUMAN GLUCURONYLTRANSFERASE,TITL 3 GLCAT-P, AN ENZYME CRITICAL IN THE BIOSYNTHESIS OFTITL 4 THE CARBOHYDRATE EPITOPE HNK-1REF J.BIOL.CHEM. V. 279 22693 2004REFN ISSN 0021-9258PMID 14993226DOI 10.1074/JBC.M400622200 […]
General Structure Information 2nz0 KCND3 crystal structure of potassium channel kv4.3 in complex with its regulatory subunit kchip1 (casp target) 3.2Å AUTH H.WANG,Y.YAN,Q.LIU,Y.HUANG,Y.SHEN,L.CHEN,Y.CHEN,Q.YANG,AUTH 2 Q.HAO,K.WANG,J.CHAITITL STRUCTURAL BASIS FOR MODULATION OF KV4 K(+) CHANNELS BYTITL 2 AUXILIARY KCHIP SUBUNITS.REF NAT.NEUROSCI. V. 10 32 2007REFN ISSN 1097-6256PMID 17187064DOI 10.1038/NN1822 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4im0 TBK1 structure of tank-binding kinase 1 2.4Å AUTH D.TU,Z.ZHU,A.Y.ZHOU,C.YUN,K.LEE,A.V.TOMS,Y.LI,G.P.DUNN,AUTH 2 E.CHAN,T.THAI,S.YANG,S.B.FICARRO,J.A.MARTO,H.JEON,W.C.HAHN,AUTH 3 D.A.BARBIE,M.J.ECKTITL STRUCTURE OF TANK-BINDING KINASE 1REF CELL.REPORTS. 2013REFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1×67 DBNL solution structure of the cofilin homology domain of hip-55 (drebrin-like protein) -1.0Å AUTH A.K.GORONCY,S.KOSHIBA,N.TOCHIO,T.TOMIZAWA,M.SATO,AUTH 2 M.INOUE,S.WATANABE,Y.HAYASHIZAKI,A.TANAKA,T.KIGAWA,AUTH 3 S.YOKOYAMATITL NMR SOLUTION STRUCTURES OF ACTIN DEPOLYMERIZINGTITL 2 FACTOR HOMOLOGY DOMAINS.REF PROTEIN SCI. V. 18 2384 2009REFN ISSN 0961-8368PMID 19768801DOI 10.1002/PRO.248 Variant Set Distributions Mapped Variants
General Structure Information 4bld SUFU crystal structure of a human suppressor of fused (sufu)- gli3p complex 2.8Å AUTH A.L.CHERRY,C.FINTA,M.KARLSTROM,Q.JIN,T.SCHWEND,AUTH 2 J.ASTORGA-WELLS,R.A.ZUBAREV,M.DEL CAMPO,A.R.CRISWELL,AUTH 3 D.DE SANCTIS,L.JOVINE,R.TOFTGARDTITL STRUCTURAL BASIS OF SUFU-GLI INTERACTION IN HEDGEHOGTITL 2 SIGNALLING REGULATIONREF ACTA CRYSTALLOGR.,SECT.D V. 69 2579 2013REFN ISSN 0907-4449PMID 24311597DOI 10.1107/S0907444913028473 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]