Assessment of Structural Intolerance and Durability
General Structure Information 3ews DDX19B human dead-box rna-helicase ddx19 in complex with adp 2.7Å AUTH R.COLLINS,T.KARLBERG,L.LEHTIO,P.SCHUTZ,AUTH 2 S.VAN DEN BERG,L.G.DAHLGREN,M.HAMMARSTROM,AUTH 3 J.WEIGELT,H.SCHULERTITL THE DEXD/H-BOX RNA HELICASE DDX19 IS REGULATED BYTITL 2 AN {ALPHA}-HELICAL SWITCH.REF J.BIOL.CHEM. V. 284 10296 2009REFN ISSN 0021-9258PMID 19244245DOI 10.1074/JBC.C900018200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ox6 CABP1 crystal structure of the calcium sensor calcium-binding protein 1 (cabp1) 2.4Å AUTH F.FINDEISEN,D.L.MINORTITL STRUCTURAL BASIS FOR THE DIFFERENTIAL EFFECTS OF CABP1 ANDTITL 2 CALMODULIN ON CA(V)1.2 CALCIUM-DEPENDENT INACTIVATION.REF STRUCTURE V. 18 1617 2010REFN ISSN 0969-2126PMID 21134641DOI 10.1016/J.STR.2010.09.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2oq5 TMPRSS11E crystal structure of desc1, a new member of the type ii transmembrane serine proteinases family 1.61Å AUTH O.J.P.KYRIELEIS,R.HUBER,E.ONG,R.OEHLER,M.HUNTER,AUTH 2 E.L.MADISON,U.JACOBTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OFTITL 2 DESC1, A NEW MEMBER OF THE TYPE II TRANSMEMBRANETITL 3 SERINE PROTEINASE FAMILY.REF FEBS J. V. 274 2148 2007REFN ISSN 1742-464XPMID 17388811DOI […]
General Structure Information 2w0u HAO1 crystal structure of human glycolate oxidase in complex with the inhibitor 5-[(4-chlorophenyl)sulfanyl]- 1,2,3-thiadiazole-4-carboxylate. 2.84Å AUTH J.M.BOURHIS,C.VIGNAUD,N.PIETRANCOSTA,F.GUERITTE,AUTH 2 D.GUENARD,F.LEDERER,Y.LINDQVISTTITL STRUCTURE OF HUMAN GLYCOLATE OXIDASE IN COMPLEXTITL 2 WITH THE INHIBITOR 4-CARBOXY-5-[(4-TITL 3 CHLOROPHENYL)SULFANYL]-1,2,3-THIADIAZOLE.REF ACTA CRYSTALLOGR.,SECT.F V. 65 1246 2009REFN ISSN 1744-3091PMID 20054120DOI 10.1107/S1744309109041670 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1w24 VPS29 crystal structure of human vps29 2.1Å AUTH D.WANG,M.GUO,Z.LIANG,J.FAN,Z.ZHU,J.ZANG,Z.ZHU,X.LI,AUTH 2 M.TENG,L.NIU,Y.DONG,P.LIUTITL CRYSTAL STRUCTURE OF HUMAN VACUOLAR PROTEINTITL 2 SORTING PROTEIN 29 REVEALS ATITL 3 PHOSPHODIESTERASE/NUCLEASE-LIKE FOLD AND TWOTITL 4 PROTEIN-PROTEIN INTERACTION SITES.REF J.BIOL.CHEM. V. 280 22962 2005REFN ISSN 0021-9258PMID 15788412DOI 10.1074/JBC.M500464200 Variant Set Distributions Mapped Variants
General Structure Information 2iwi PIM2 crystal structure of the human pim2 in complex with a ruthenium organometallic ligand ru1 2.8Å AUTH A.N.BULLOCK,S.RUSSO,A.AMOS,N.PAGANO,H.BREGMAN,AUTH 2 J.E.DEBRECZENI,W.H.LEE,F.VON DELFT,E.MEGGERS,AUTH 3 S.KNAPPTITL CRYSTAL STRUCTURE OF THE PIM2 KINASE IN COMPLEXTITL 2 WITH AN ORGANORUTHENIUM INHIBITOR.REF PLOS ONE V. 4 E7112 2009REFN ISSN 1932-6203PMID 19841674DOI 10.1371/JOURNAL.PONE.0007112 Variant Set Distributions Ripley’s K […]
General Structure Information 2mkd ZNF346 human jaz zf3 residues 168-227 -1.0Å AUTH R.G.BURGE,M.A.MARTINEZ-YAMOUT,H.J.DYSON,P.E.WRIGHTTITL STRUCTURAL CHARACTERIZATION OF INTERACTIONS BETWEEN THETITL 2 DOUBLE-STRANDED RNA-BINDING ZINC FINGER PROTEIN JAZ ANDTITL 3 NUCLEIC ACIDS.REF BIOCHEMISTRY V. 53 1495 2014REFN ISSN 0006-2960PMID 24521053DOI 10.1021/BI401675H Variant Set Distributions Mapped Variants
General Structure Information 1lg4 PRND nmr structure of the human doppel protein fragment 24-152 -1.0Å AUTH T.LUHRS,R.RIEK,P.GUNTERT,K.WUTHRICHTITL NMR STRUCTURE OF THE HUMAN DOPPEL PROTEINREF J.MOL.BIOL. V. 326 1549 2003REFN ISSN 0022-2836PMID 12595265DOI 10.1016/S0022-2836(02)01471-7 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2q13 APPL1 crystal structure of bar-ph domain of appl1 2.05Å AUTH G.ZHU,J.CHEN,J.LIU,J.S.BRUNZELLE,B.HUANG,N.WAKEHAM,AUTH 2 S.TERZYAN,X.LI,Z.RAO,G.LI,X.C.ZHANGTITL STRUCTURE OF THE APPL1 BAR-PH DOMAIN AND CHARACTERIZATION OFTITL 2 ITS INTERACTION WITH RAB5.REF EMBO J. V. 26 3484 2007REFN ISSN 0261-4189PMID 17581628DOI 10.1038/SJ.EMBOJ.7601771 Variant Set Distributions Mapped Variants
General Structure Information 3iei LCMT1 crystal structure of human leucine carboxylmethyltransferase-1 in complex with s-adenosyl homocysteine 1.9Å AUTH V.STANEVICH,L.JIANG,K.A.SATYSHUR,Y.LI,P.D.JEFFREY,Z.LI,AUTH 2 M.F.SEMMELHACK,Y.XINGTITL STRUCTURAL INSIGHTS INTO NOVEL FUNCTIONS OF A PRO-SURVIVALTITL 2 PP2A-SPECIFIC METHYLTRANSFERASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants