Assessment of Structural Intolerance and Durability
General Structure Information 3ob9 MSL3 structure of the human msl3 chromo-barrel domain at 2.5 angstrom resolution 2.5Å AUTH S.A.MOORE,Y.FERHATOGLUTITL STRUCTURE OF THE HUMAN MSL3 CHROMO-BARREL DOMAIN AT 2.5TITL 2 ANGSTROM RESOLUTIONREF J.BIOL.CHEM. 2010REFN ESSN 1083-351X Variant Set Distributions Mapped Variants
General Structure Information 2h00 METTL16 human methyltransferase 10 domain containing protein 2.0Å AUTH H.WU,J.MIN,H.ZENG,P.LOPPNAU,J.WEIGELT,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN METHYLTRANSFERASETITL 2 10 DOMAIN CONTAINING PROTEIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2l76 NFATC2IP solution nmr structure of human nfatc2ip ubiquitin-like domain, nfatc2ip_244_338, nesg target ht65a/ocsp target hs00387_244_338/sgc- toronto -1.0Å AUTH R.DOHERTY,B.WU,A.YEE,A.LEMAK,S.HOULISTON,C.FARES,S.SRISALAM,AUTH 2 C.BULTER,A.M.EDWARDS,J.WEIGELT,S.DHE-PAGANON,C.H.ARROWSMITHTITL HUMAN NFATC2IP UBIQUITIN-LIKE DOMAINSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2xeq PATL1 human patl1 c-terminal domain 3.1Å AUTH J.E.BRAUN,F.TRITSCHLER,G.HAAS,C.IGREJA,V.TRUFFAULT,AUTH 2 O.WEICHENRIEDER,E.IZAURRALDETITL THE C-TERMINAL ALPHA-ALPHA SUPERHELIX OF PAT ISTITL 2 REQUIRED FOR MRNA DECAPPING IN METAZOA.REF EMBO J. V. 29 2368 2010REFN ISSN 0261-4189PMID 20543818DOI 10.1038/EMBOJ.2010.124 Variant Set Distributions Mapped Variants
General Structure Information 1zbu ERI1 crystal structure of full-length 3-exonuclease 3.0Å AUTH Y.CHENG,D.J.PATELTITL STRUCTURAL BASIS FOR 3-END SPECIFIC RECOGNITION OF HISTONETITL 2 MRNA STEM-LOOP BY 3-EXONUCLEASE, A HUMAN NUCLEASE THAT ALSOTITL 3 TARGETS SIRNAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ihy PIK3C3 human pik3c3 crystal structure 2.8Å AUTH M.I.SIPONEN,L.TRESAUGUES,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I JOHANSSON,AUTH 4 T.KARLBERG,T.KOTENYOVA,A.KOTZSCH,T.KRAGH NIELSEN,AUTH 5 M.MOCHE,T.NYMAN,C.PERSSON,A.K.ROOS,J.SAGEMARK,AUTH 6 H.SCHUELER,P.SCHUTZ,A.G.THORSELL,S.VAN DEN BERG,AUTH 7 J.WEIGELT,M.WELIN,M.WISNIEWSKA,P.NORDLUNDTITL HUMAN PIK3C3 CRYSTAL STRUCTUREREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3g07 MEPCE methyltransferase domain of human bicoid-interacting protein 3 homolog (drosophila) 2.65Å AUTH H.WU,L.DOMBROVSKI,W.TEMPEL,A.MCCARTHY,P.LOPPNAU,AUTH 2 J.MIN,A.N.PLOTNIKOV,H.PARKTITL METHYLTRANSFERASE DOMAIN OF HUMANTITL 2 BICOID-INTERACTING PROTEIN 3 HOMOLOG (DROSOPHILA)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2fmm C11orf30 crystal structure of emsy-hp1 complex 1.8Å AUTH Y.HUANG,M.P.MYERS,R.M.XUTITL CRYSTAL STRUCTURE OF THE HP1-EMSY COMPLEX REVEALS AN UNUSUALTITL 2 MODE OF HP1 BINDING.REF STRUCTURE V. 14 703 2006REFN ISSN 0969-2126PMID 16615912DOI 10.1016/J.STR.2006.01.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2f4w UBE2J2 human ubiquitin-conjugating enzyme e2 j2 2.0Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1wfm SYT13 the first c2 domain of human synaptotagmin xiii -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL THE FIRST C2 DOMAIN OF HUMAN SYNAPTOTAGMIN XIIIREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants