General Structure Information
| PDB ID | 2h00 |
| HGNC Gene Label(s) | METTL16 |
| Structure Name | human methyltransferase 10 domain containing protein |
| Resolution | 2.0Å |
| Reference | AUTH H.WU,J.MIN,H.ZENG,P.LOPPNAU,J.WEIGELT,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN METHYLTRANSFERASETITL 2 10 DOMAIN CONTAINING PROTEIN.REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 225 |
| Number Of SNVs | 21 |
| Number Of Permutations | 3026 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.138 |
| p-value | 0.424 |
COSMIC
| Number Of Residues | 225 |
| Number Of SNVs | 4 |
| Number Of Permutations | 420 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.167 |
| p-value | 0.548 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 21 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.138 |
| p-value | 0.675 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
