Assessment of Structural Intolerance and Durability
General Structure Information 3zkj ASB9 crystal structure of ankyrin repeat and socs box-containing protein 9 (asb9) in complex with elonginb and elonginc 2.58Å AUTH J.R.C.MUNIZ,K.GUO,N.J.KERSHAW,V.AYINAMPUDI,F.VON DELFT,AUTH 2 J.J.BABON,A.N.BULLOCKTITL MOLECULAR ARCHITECTURE OF THE ANKYRIN SOCS BOX FAMILY OFTITL 2 CUL5-DEPENDENT E3 UBIQUITIN LIGASESREF J.MOL.BIOL. V. 425 3166 2013REFN ISSN 0022-2836PMID 23806657DOI 10.1016/J.JMB.2013.06.015 Variant Set Distributions Ripley’s […]
General Structure Information 4jgh CUL5 structure of the socs2-elongin bc complex bound to an n-terminal fragment of cullin5 3.0Å AUTH Y.K.KIM,M.J.KWAK,B.KU,H.Y.SUH,K.JOO,J.LEE,J.U.JUNG,B.H.OHTITL STRUCTURAL BASIS OF INTERSUBUNIT RECOGNITION IN ELONGINTITL 2 BC-CULLIN 5-SOCS BOX UBIQUITIN-PROTEIN LIGASE COMPLEXES.REF ACTA CRYSTALLOGR.,SECT.D V. 69 1587 2013REFN ISSN 0907-4449PMID 23897481DOI 10.1107/S0907444913011220 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4fp9 NSUN4 human mterf4-nsun4 protein complex 2.9Å AUTH H.SPAHR,B.HABERMANN,C.M.GUSTAFSSON,N.G.LARSSON,B.M.HALLBERGTITL STRUCTURE OF THE HUMAN MTERF4-NSUN4 PROTEIN COMPLEX THATTITL 2 REGULATES MITOCHONDRIAL RIBOSOME BIOGENESIS.REF PROC.NATL.ACAD.SCI.USA V. 109 15253 2012REFN ISSN 0027-8424PMID 22949673DOI 10.1073/PNAS.1210688109 Variant Set Distributions Mapped Variants
General Structure Information 2fv2 RQCD1 crystal structure analysis of human rcd-1 conserved region 2.2Å AUTH R.G.GARCES,W.GILLON,E.F.PAITITL ATOMIC MODEL OF HUMAN RCD-1 REVEALS ANTITL 2 ARMADILLO-LIKE-REPEAT PROTEIN WITH IN VITROTITL 3 NUCLEIC ACID BINDING PROPERTIES.REF PROTEIN SCI. V. 16 176 2007REFN ISSN 0961-8368PMID 17189474DOI 10.1110/PS.062600507 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4n4f CREBBP crystal structure of the bromodomain-phd finger module of human transcriptional co-activator cbp in complex with di-acetylated histone 4 peptide (h412ack16ac). 1.83Å AUTH A.N.PLOTNIKOV,S.YANG,T.J.ZHOU,E.RUSINOVA,A.FRASCA,M.M.ZHOUTITL STRUCTURAL INSIGHTS INTO ACETYLATED-HISTONE H4 RECOGNITIONTITL 2 BY THE BROMODOMAIN-PHD FINGER MODULE OF HUMANTITL 3 TRANSCRIPTIONAL COACTIVATOR CBP.REF STRUCTURE V. 22 353 2014REFN ISSN 0969-2126PMID 24361270DOI 10.1016/J.STR.2013.10.021 […]
General Structure Information 4fjv OTUB2 crystal structure of human otubain2 and ubiquitin complex 2.05Å AUTH M.ALTUN,T.S.WALTER,H.B.KRAMER,P.HERR,A.IPHOFER,J.BOSTROM,AUTH 2 Y.DAVID,A.KOMSANY,N.TERNETTE,A.NAVON,D.I.STUART,J.REN,AUTH 3 B.M.KESSLERTITL THE HUMAN OTUBAIN2-UBIQUITIN STRUCTURE PROVIDES INSIGHTSTITL 2 INTO THE CLEAVAGE SPECIFICITY OF POLY-UBIQUITIN-LINKAGES.REF PLOS ONE V. 10 15344 2015REFN ESSN 1932-6203PMID 25590432DOI 10.1371/JOURNAL.PONE.0115344 Variant Set Distributions Mapped Variants
General Structure Information 2izv SOCS4 crystal structure of socs-4 in complex with elongin-b and elongin-c at 2.55a resolution 2.55Å AUTH A.N.BULLOCK,M.C.RODRIGUEZ,J.E.DEBRECZENI,Z.SONGYANG,S.KNAPPTITL STRUCTURE OF THE SOCS4-ELONGINB/C COMPLEX REVEALS ATITL 2 DISTINCT SOCS BOX INTERFACE AND THE MOLECULAR BASIS FORTITL 3 SOCS-DEPENDENT EGFR DEGRADATION.REF STRUCTURE V. 15 1493 2007REFN ISSN 0969-2126PMID 17997974DOI 10.1016/J.STR.2007.09.016 Variant Set Distributions Mapped […]
General Structure Information 2edi UBE2F solution structure of the uq_con domain from human nedd8- conjugating enzyme nce2 -1.0Å AUTH H.ENDO,K.IZUMI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE UQ_CON DOMAIN FROM HUMANTITL 2 NEDD8-CONJUGATING ENZYME NCE2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2wwm TTN crystal structure of the titin m10-obscurin like 1 ig complex in space group p1 2.3Å AUTH S.PERNIGO,A.FUKUZAWA,M.BERTZ,M.HOLT,M.RIEF,R.A.STEINER,AUTH 2 M.GAUTELTITL STRUCTURAL INSIGHT INTO M-BAND ASSEMBLY AND MECHANICS FROMTITL 2 THE TITIN-OBSCURIN-LIKE-1 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 107 2908 2010REFN ISSN 0027-8424PMID 20133654DOI 10.1073/PNAS.0913736107 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2i46 ACD crystal structure of human tpp1 2.7Å AUTH F.WANG,E.R.PODELL,A.J.ZAUG,Y.YANG,P.BACIU,T.R.CECH,AUTH 2 M.LEITITL THE POT1-TPP1 TELOMERE COMPLEX IS A TELOMERASETITL 2 PROCESSIVITY FACTOR.REF NATURE V. 445 506 2007REFN ISSN 0028-0836PMID 17237768DOI 10.1038/NATURE05454 Variant Set Distributions Mapped Variants