Assessment of Structural Intolerance and Durability
General Structure Information 3o3i PIWIL1 crystal structure of human hiwi1 paz domain (residues 277-399) in complex with 14-mer rna (12-bp + 2-nt overhang) containing 2-oh at its 3-end 2.8Å AUTH Y.TIAN,D.K.SIMANSHU,J.B.MA,D.J.PATELTITL INAUGURAL ARTICLE: STRUCTURAL BASIS FOR PIRNATITL 2 2-O-METHYLATED 3-END RECOGNITION BY PIWI PAZTITL 3 (PIWI/ARGONAUTE/ZWILLE) DOMAINS.REF PROC.NATL.ACAD.SCI.USA V. 108 903 2011REFN ISSN 0027-8424PMID 21193640DOI […]
General Structure Information 3qp3 TTN crystal structure of titin domain m4, tetragonal form 2.0Å AUTH F.SAUER,A.KOLODZIEJCZYK,M.WILMANNSTITL CRYSTAL STRUCTURE OF TITIN DOMAIN M4, TETRAGONAL FORMREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3rjw EHMT2 crystal structure of histone lysine methyltransferase g9a with an inhibitor 2.56Å AUTH M.VEDADI,D.BARSYTE-LOVEJOY,F.LIU,S.RIVAL-GERVIER,AUTH 2 A.ALLALI-HASSANI,V.LABRIE,T.J.WIGLE,P.A.DIMAGGIO,G.A.WASNEY,AUTH 3 A.SIARHEYEVA,A.DONG,W.TEMPEL,S.C.WANG,X.CHEN,I.CHAU,AUTH 4 T.J.MANGANO,X.P.HUANG,C.D.SIMPSON,S.G.PATTENDEN,J.L.NORRIS,AUTH 5 D.B.KIREEV,A.TRIPATHY,A.EDWARDS,B.L.ROTH,W.P.JANZEN,AUTH 6 B.A.GARCIA,A.PETRONIS,J.ELLIS,P.J.BROWN,S.V.FRYE,AUTH 7 C.H.ARROWSMITH,J.JINTITL A CHEMICAL PROBE SELECTIVELY INHIBITS G9A AND GLPTITL 2 METHYLTRANSFERASE ACTIVITY IN CELLS.REF NAT.CHEM.BIOL. V. 7 566 2011REFN ISSN 1552-4450PMID 21743462DOI 10.1038/NCHEMBIO.599 Variant Set Distributions […]
General Structure Information 2uzc PDLIM5 structure of human pdlim5 in complex with the c-terminal peptide of human alpha-actinin-1 1.5Å AUTH J.M.ELKINS,C.GILEADI,L.SHRESTHA,C.PHILLIPS,J.WANG,AUTH 2 J.R.C.MUNIZ,D.A.DOYLETITL UNUSUAL BINDING INTERACTIONS IN PDZ DOMAIN CRYSTALTITL 2 STRUCTURES HELP EXPLAIN BINDING MECHANISMS.REF PROTEIN SCI. V. 19 731 2010REFN ISSN 0961-8368PMID 20120020DOI 10.1002/PRO.349 Variant Set Distributions Mapped Variants
General Structure Information 3aj4 PLEKHB2 crystal structure of the ph domain of evectin-2 from human complexed with o-phospho-l-serine 1.0Å AUTH Y.UCHIDA,J.HASEGAWA,D.CHINNAPEN,T.INOUE,S.OKAZAKI,R.KATO,AUTH 2 S.WAKATSUKI,R.MISAKI,M.KOIKE,Y.UCHIYAMA,S.IEMURA,T.NATSUME,AUTH 3 R.KUWAHARA,T.NAKAGAWA,K.NISHIKAWA,K.MUKAI,E.MIYOSHI,AUTH 4 N.TANIGUCHI,D.SHEFF,W.I.LENCER,T.TAGUCHI,H.ARAITITL INTRACELLULAR PHOSPHATIDYLSERINE IS ESSENTIAL FOR RETROGRADETITL 2 MEMBRANE TRAFFIC THROUGH ENDOSOMESREF PROC.NATL.ACAD.SCI.USA V. 108 15846 2011REFN ISSN 0027-8424PMID 21911378DOI 10.1073/PNAS.1109101108 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1bpv TTN titin module a71 from human cardiac muscle, nmr, 50 structures -1.0Å AUTH C.M.GOLL,A.PASTORE,M.NILGESTITL THE THREE-DIMENSIONAL STRUCTURE OF A TYPE I MODULETITL 2 FROM TITIN: A PROTOTYPE OF INTRACELLULARTITL 3 FIBRONECTIN TYPE III DOMAINS.REF STRUCTURE V. 6 1291 1998REFN ISSN 0969-2126PMID 9782056DOI 10.1016/S0969-2126(98)00129-4 Variant Set Distributions Mapped Variants
General Structure Information 2zme SNF8 integrated structural and functional model of the human escrt-ii complex 2.9Å AUTH Y.J.IM,J.H.HURLEYTITL INTEGRATED STRUCTURAL MODEL AND MEMBRANE TARGETING MECHANISMTITL 2 OF THE HUMAN ESCRT-II COMPLEXREF DEV.CELL V. 14 902 2008REFN ISSN 1534-5807PMID 18539118DOI 10.1016/J.DEVCEL.2008.04.004 Variant Set Distributions Mapped Variants
General Structure Information 2pd6 HSD17B8 structure of human hydroxysteroid dehydrogenase type 8, hsd17b8 2.0Å AUTH A.P.TURNBULL,E.SALAH,O.GILEADI,P.SAVITSKY,K.GUO,G.BUNKOCZI,AUTH 2 A.C.W.PIKE,E.UGOCHUKWU,C.UMEANO,F.VON DELFT,J.WEIGELT,AUTH 3 C.H.ARROWSMITH,M.SUNDSTROM,A.EDWARDS,U.OPPERMANN,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL STRUCTURE OF HUMAN HYDROXYSTEROID DEHYDROGENASE TYPE 8,TITL 2 HSD17B8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3siu PRPF31 structure of a hprp31-15.5k-u4atac 5 stem loop complex, monomeric form 2.63Å AUTH S.LIU,H.GHALEI,R.LUHRMANN,M.C.WAHLTITL STRUCTURAL BASIS FOR THE DUAL U4 AND U4ATAC SNRNA-BINDINGTITL 2 SPECIFICITY OF SPLICEOSOMAL PROTEIN HPRP31.REF RNA V. 17 1655 2011REFN ISSN 1355-8382PMID 21784869DOI 10.1261/RNA.2690611 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2f8v TTN structure of full length telethonin in complex with the n-terminus of titin 2.75Å AUTH N.PINOTSIS,M.PETOUKHOV,S.LANGE,D.SVERGUN,P.ZOU,M.GAUTEL,AUTH 2 M.WILMANNSTITL EVIDENCE FOR A DIMERIC ASSEMBLY OF TWO TITIN/TELETHONINTITL 2 COMPLEXES INDUCED BY THE TELETHONIN C-TERMINUS.REF J.STRUCT.BIOL. V. 155 239 2006REFN ISSN 1047-8477PMID 16713295DOI 10.1016/J.JSB.2006.03.028 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]