Assessment of Structural Intolerance and Durability
General Structure Information 4m6t LEO1 structure of human paf1 and leo1 complex 2.5Å AUTH X.CHU,X.QIN,H.XU,L.LI,Z.WANG,F.LI,X.XIE,H.ZHOU,Y.SHEN,J.LONGTITL STRUCTURAL INSIGHTS INTO PAF1 COMPLEX ASSEMBLY AND HISTONETITL 2 BINDINGREF NUCLEIC ACIDS RES. V. 41 10619 2013REFN ISSN 0305-1048PMID 24038468DOI 10.1093/NAR/GKT819 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ff7 KLRG1 structure of nk cell receptor klrg1 bound to e-cadherin 1.8Å AUTH Y.LI,M.HOFMANN,Q.WANG,L.TENG,L.K.CHLEWICKI,AUTH 2 H.PIRCHER,R.A.MARIUZZATITL STRUCTURE OF NATURAL KILLER CELL RECEPTOR KLRG1TITL 2 BOUND TO E-CADHERIN REVEALS BASIS FORTITL 3 MHC-INDEPENDENT MISSING SELF RECOGNITION.REF IMMUNITY V. 31 35 2009REFN ISSN 1074-7613PMID 19604491DOI 10.1016/J.IMMUNI.2009.04.019 Variant Set Distributions Mapped Variants
General Structure Information 2yho MYLIP the idol-ube2d complex mediates sterol-dependent degradation of the ldl receptor 2.1Å AUTH L.ZHANG,L.FAIRALL,B.T.GOULT,A.C.CALKIN,C.HONG,C.J.MILLARD,AUTH 2 P.TONTONOZ,J.W.SCHWABETITL THE IDOL-UBE2D COMPLEX MEDIATES STEROL-DEPENDENTTITL 2 DEGRADATION OF THE LDL RECEPTOR.REF GENES DEV. V. 25 1262 2011REFN ISSN 0890-9369PMID 21685362DOI 10.1101/GAD.2056211 Variant Set Distributions Mapped Variants
General Structure Information 2jvz KHSRP solution nmr structure of the second and third kh domains of ksrp -1.0Å AUTH I.DIAZ-MORENO,D.HOLLINGWORTH,M.F.GARCIA-MAYORAL,AUTH 2 G.KELLY,S.MARTIN,C.Y.CHEN,A.RAMOSTITL SOLUTION NMR STRUCTURE OF THE SECOND AND THIRD KHTITL 2 DOMAINS OF KSRPREF TO BE PUBLISHED 2007REFN Variant Set Distributions Mapped Variants
General Structure Information 2ksn UBTD2 solution structure of the n-terminal domain of dc-ubp/ubtd2 -1.0Å AUTH A.SONG,C.ZHOU,X.GUAN,K.SZE,H.HUTITL SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF DC-UBP/UBTD2TITL 2 AND ITS INTERACTION WITH UBIQUITINREF PROTEIN SCI. V. 19 1104 2010REFN ISSN 0961-8368PMID 20440844DOI 10.1002/PRO.386 Variant Set Distributions Mapped Variants
General Structure Information 2ylm USP7 mechanism of usp7 (hausp) activation by its c-terminal ubiquitin-like domain (hubl) and allosteric regulation by gmp-synthetase. 2.7Å AUTH A.C.FAESEN,A.M.G.DIRAC,A.SHANMUGHAM,H.OVAA,A.PERRAKIS,AUTH 2 T.K.SIXMATITL MECHANISM OF USP7/HAUSP ACTIVATION BY ITS C- TERMINALTITL 2 UBIQUITIN-LIKE DOMAIN AND ALLOSTERIC REGULATION BYTITL 3 GMP-SYNTHETASEREF MOL.CELL V. 44 147 2011REFN ISSN 1097-2765PMID 21981925DOI 10.1016/J.MOLCEL.2011.06.034 Variant Set Distributions […]
General Structure Information 1ury CYGB cytoglobin cavities 2.4Å AUTH D.DE SANCTIS,S.DEWILDE,A.PESCE,L.MOENS,P.ASCENZI,AUTH 2 T.HANKELN,T.BURMESTER,M.BOLOGNESITITL CYTOGLOBIN CAVITIESREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 316 1217 2004REFN ISSN 0006-291XPMID 15044115DOI 10.1016/J.BBRC.2004.03.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2r0b STYX crystal structure of human tyrosine phosphatase-like serine/threonine/tyrosine-interacting protein 1.6Å AUTH S.C.ALMO,J.B.BONANNO,J.M.SAUDER,S.EMTAGE,T.P.DILORENZO,AUTH 2 V.MALASHKEVICH,S.R.WASSERMAN,S.SWAMINATHAN,S.ESWARAMOORTHY,AUTH 3 R.AGARWAL,D.KUMARAN,M.MADEGOWDA,S.RAGUMANI,Y.PATSKOVSKY,AUTH 4 J.ALVARADO,U.A.RAMAGOPAL,J.FABER-BARATA,M.R.CHANCE,A.SALI,AUTH 5 A.FISER,Z.Y.ZHANG,D.S.LAWRENCE,S.K.BURLEYTITL STRUCTURAL GENOMICS OF PROTEIN PHOSPHATASES.REF J.STRUCT.FUNCT.GENOM. V. 8 121 2007REFN ISSN 1345-711XPMID 18058037DOI 10.1007/S10969-007-9036-1 Variant Set Distributions Mapped Variants
General Structure Information 4hnm CTNNBL1 crystal structure of human catenin-beta-like 1 56 kda fragment 2.9Å AUTH X.HUANG,G.WANG,Y.WU,Z.DUTITL THE STRUCTURE OF FULL-LENGTH HUMAN CTNNBL1 REVEALS ATITL 2 DISTINCT MEMBER OF THE ARMADILLO-REPEAT PROTEIN FAMILY.REF ACTA CRYSTALLOGR.,SECT.D V. 69 1598 2013REFN ISSN 0907-4449PMID 23897482DOI 10.1107/S0907444913011360 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3nw0 NSMCE1 crystal structure of mageg1 and nse1 complex 2.92Å AUTH J.M.DOYLE,J.GAO,J.WANG,M.YANG,P.R.POTTSTITL MAGE-RING PROTEIN COMPLEXES COMPRISE A FAMILY OF E3TITL 2 UBIQUITIN LIGASES.REF MOL.CELL V. 39 963 2010REFN ISSN 1097-2765PMID 20864041DOI 10.1016/J.MOLCEL.2010.08.029 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants