Assessment of Structural Intolerance and Durability
General Structure Information 1lmj FBN1 nmr study of the fibrillin-1 cbegf12-13 pair of ca2+ binding epidermal growth factor-like domains -1.0Å AUTH R.S.SMALLRIDGE,P.WHITEMAN,J.M.WERNER,I.D.CAMPBELL,AUTH 2 P.A.HANDFORD,A.K.DOWNINGTITL SOLUTION STRUCTURE AND DYNAMICS OF A CALCIUMTITL 2 BINDING EPIDERMAL GROWTH FACTOR-LIKE DOMAIN PAIRTITL 3 FROM THE NEONATAL REGION OF HUMAN FIBRILLIN-1.REF J.BIOL.CHEM. V. 278 12199 2003REFN ISSN 0021-9258PMID 12511552DOI 10.1074/JBC.M208266200 […]
General Structure Information 2kax S100A5 solution structure and dynamics of s100a5 in the apo and ca2+ -bound states -1.0Å AUTH I.BERTINI,S.DAS GUPTA,X.HU,T.KARAVELAS,C.LUCHINAT,AUTH 2 G.PARIGI,J.YUANTITL SOLUTION STRUCTURE AND DYNAMICS OF S100A5 IN THETITL 2 APO AND CA2+-BOUND STATESREF J.BIOL.INORG.CHEM. V. 14 1097 2009REFN ISSN 0949-8257PMID 19536568DOI 10.1007/S00775-009-0553-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2ew9 ATP7B solution structure of apowln5-6 -1.0Å AUTH D.ACHILA,L.BANCI,I.BERTINI,J.BUNCE,S.CIOFI-BAFFONI,AUTH 2 D.L.HUFFMANTITL STRUCTURE OF HUMAN WILSON PROTEIN DOMAINS 5 AND 6TITL 2 AND THEIR INTERPLAY WITH DOMAIN 4 AND THE COPPERTITL 3 CHAPERONE HAH1 IN COPPER UPTAKE.REF PROC.NATL.ACAD.SCI.USA V. 103 5729 2006REFN ISSN 0027-8424PMID 16571664DOI 10.1073/PNAS.0504472103 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1wz9 SERPINB5 the 2.1 a structure of a tumour suppressing serpin 2.1Å AUTH R.H.LAW,J.A.IRVING,A.M.BUCKLE,K.RUZYLA,M.BUZZA,AUTH 2 T.A.BASHTANNYK-PUHALOVICH,T.C.BEDDOE,K.NGUYEN,AUTH 3 D.M.WORRALL,S.P.BOTTOMLEY,P.I.BIRD,J.ROSSJOHN,AUTH 4 J.C.WHISSTOCKTITL THE HIGH RESOLUTION CRYSTAL STRUCTURE OF THE HUMANTITL 2 TUMOR SUPPRESSOR MASPIN REVEALS A NOVELTITL 3 CONFORMATIONAL SWITCH IN THE G-HELIX.REF J.BIOL.CHEM. V. 280 22356 2005REFN ISSN 0021-9258PMID 15760906DOI 10.1074/JBC.M412043200 Variant Set […]
General Structure Information 1l4t CCKBR solution nmr structure of the cck2e3 -1.0Å AUTH C.GIRAGOSSIAN,D.F.MIERKETITL INTERMOLECULAR INTERACTIONS BETWEENTITL 2 CHOLECYSTOKININ-8 AND THE THIRD EXTRACELLULAR LOOPTITL 3 OF THE CHOLECYSTOKININ-2 RECEPTORREF BIOCHEMISTRY V. 41 4560 2002REFN ISSN 0006-2960PMID 11926817DOI 10.1021/BI0160009 Variant Set Distributions Mapped Variants
General Structure Information 3g81 SFTPD crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein d in complex with alpha methyl mannoside 1.8Å AUTH E.CROUCH,K.HARTSHORN,T.HORLACHER,B.MCDONALD,K.SMITH,AUTH 2 T.CAFARELLA,B.SEATON,P.H.SEEBERGER,J.HEADTITL RECOGNITION OF MANNOSYLATED LIGANDS AND INFLUENZA A VIRUS BYTITL 2 HUMAN SURFACTANT PROTEIN D: CONTRIBUTIONS OF AN EXTENDEDTITL 3 SITE AND RESIDUE 343.REF BIOCHEMISTRY […]
General Structure Information 4fl2 SYK structural and biophysical characterization of the syk activation switch 2.19Å AUTH U.GRADLER,D.SCHWARZ,V.DRESING,D.MUSIL,J.BOMKE,M.FRECH,AUTH 2 H.GREINER,S.JAKEL,T.RYSIOK,D.MULLER-POMPALLA,A.WEGENERTITL STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OF THE SYKTITL 2 ACTIVATION SWITCH.REF J.MOL.BIOL. V. 425 309 2013REFN ISSN 0022-2836PMID 23154170DOI 10.1016/J.JMB.2012.11.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3lmk GRM5 ligand binding domain of metabotropoc glutamate receptor mglur5 complexed with glutamate 2.44Å AUTH E.DOBROVETSKY,G.KHUTORESKAYA,A.SEITOVA,D.COSSAR,A.M.EDWARDS,AUTH 2 C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,A.BOCHKAREVTITL METABOTROPIC GLUTAMATE RECEPTOR MGLUR5 COMPLEXED WITHTITL 2 GLUTAMATEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ovl NR4A2 crystal structure of nurr1 lbd 2.2Å AUTH Z.WANG,G.BENOIT,J.LIU,S.PRASAD,P.AARNISALO,X.LIU,AUTH 2 H.XU,N.WALKER,T.PERLMANNTITL STRUCTURE AND FUNCTION OF NURR1 IDENTIFIES A CLASSTITL 2 OF LIGAND-INDEPENDENT NUCLEAR RECEPTORSREF NATURE V. 423 555 2003REFN ISSN 0028-0836PMID 12774125DOI 10.1038/NATURE01645 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1pkx ATIC crystal structure of human atic in complex with xmp 1.9Å AUTH D.W.WOLAN,C.G.CHEONG,S.E.GREASLEY,I.A.WILSONTITL STRUCTURAL INSIGHTS INTO THE HUMAN AND AVIAN IMPTITL 2 CYCLOHYDROLASE MECHANISM VIA CRYSTAL STRUCTURESTITL 3 WITH THE BOUND XMP INHIBITOR.REF BIOCHEMISTRY V. 43 1171 2004REFN ISSN 0006-2960PMID 14756553DOI 10.1021/BI030162I Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]