Assessment of Structural Intolerance and Durability
General Structure Information 2m59 KDR spatial structure of dimeric vegfr2 membrane domain in dpc micelles -1.0Å AUTH K.S.MINEEV,A.S.ARSENIEV,M.A.SHULEPKO,E.N.LYUKMANOVATITL SPATIAL STRUCTURE OF DIMERIC VEGFR2 MEMBRANE DOMAIN IN DPCTITL 2 MICELLESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ga7 SERPINB1 crystal structure of human serpinb1 mutant 2.9Å AUTH L.WANG,Q.LI,L.WU,S.LIU,Y.ZHANG,X.YANG,P.ZHU,H.ZHANG,K.ZHANG,AUTH 2 J.LOU,P.LIU,L.TONG,F.SUN,Z.FANTITL IDENTIFICATION OF SERPINB1 AS A PHYSIOLOGICAL INHIBITOR OFTITL 2 HUMAN GRANZYME HREF J.IMMUNOL. V. 190 1319 2013REFN ISSN 0022-1767PMID 23269243DOI 10.4049/JIMMUNOL.1202542 Variant Set Distributions Mapped Variants
General Structure Information 1hci ACTN2 crystal structure of the rod domain of alpha-actinin 2.8Å AUTH J.YLANNE,K.SCHEFFZEK,P.YOUNG,M.SARASTETITL CRYSTAL STRUCTURE OF THE ALPHA-ACTININ ROD REVEALSTITL 2 AN EXTENSIVE TORSIONAL TWISTREF STRUCTURE V. 9 597 2001REFN ISSN 0969-2126PMID 11470434DOI 10.1016/S0969-2126(01)00619-0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1qmv PRDX2 thioredoxin peroxidase b from red blood cells 1.7Å AUTH E.SCHRODER,J.A.LITTLECHILD,A.A.LEBEDEV,N.ERRINGTON,AUTH 2 A.A.VAGIN,M.N.ISUPOVTITL CRYSTAL STRUCTURE OF DECAMERIC 2-CYS PEROXIREDOXIN FROMTITL 2 HUMAN ERYTHROCYTES AT 1.7 A RESOLUTION.REF STRUCTURE V. 8 605 2000REFN ISSN 0969-2126PMID 10873855DOI 10.1016/S0969-2126(00)00147-7 Variant Set Distributions Mapped Variants
General Structure Information 2×57 VIPR2 crystal structure of the extracellular domain of human vasoactive intestinal polypeptide receptor 2 2.1Å AUTH A.C.W.PIKE,A.J.BARR,A.QUIGLEY,N.BURGESS BROWN,A.DE RISO,AUTH 2 A.BULLOCK,G.BERRIDGE,J.R.C.MUNIZ,A.CHAIKAUD,M.VOLLMAR,AUTH 3 T.KROJER,E.UGOCHUKWU,F.VON DELFT,A.EDWARDS,C.H.ARROWSMITH,AUTH 4 J.WEIGELT,C.BOUNTRA,E.P.CARPENTERTITL CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMANTITL 2 VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4igg CTNNA1 full-length human alpha-catenin crystal structure 3.66Å AUTH E.S.RANGARAJAN,T.IZARDTITL DIMER ASYMMETRY DEFINES ALPHA-CATENIN INTERACTIONS.REF NAT.STRUCT.MOL.BIOL. V. 20 188 2013REFN ISSN 1545-9993PMID 23292143DOI 10.1038/NSMB.2479 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1xfd DPP6 structure of a human a-type potassium channel accelerating factor dppx, a member of the dipeptidyl aminopeptidase family 3.0Å AUTH P.STROP,A.J.BANKOVICH,K.C.HANSEN,K.C.GARCIA,A.T.BRUNGERTITL STRUCTURE OF A HUMAN A-TYPE POTASSIUM CHANNEL INTERACTINGTITL 2 PROTEIN DPPX, A MEMBER OF THE DIPEPTIDYL AMINOPEPTIDASETITL 3 FAMILYREF J.MOL.BIOL. V. 343 1055 2004REFN ISSN 0022-2836PMID 15476821DOI 10.1016/J.JMB.2004.09.003 Variant Set […]
General Structure Information 3c59 GLP1R crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain 2.3Å AUTH S.RUNGE,H.THOGERSEN,K.MADSEN,J.LAU,R.RUDOLPHTITL CRYSTAL STRUCTURE OF THE LIGAND-BOUND GLUCAGON-LIKETITL 2 PEPTIDE-1 RECEPTOR EXTRACELLULAR DOMAINREF J.BIOL.CHEM. V. 283 11340 2008REFN ISSN 0021-9258PMID 18287102DOI 10.1074/JBC.M708740200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1j72 CAPG crystal structure of mutant macrophage capping protein (cap g) with actin-severing activity in the ca2+-free form 2.5Å AUTH S.M.VOROBIEV,F.S.SOUTHWICK,B.STOROKOPYTOV,S.C.ALMOTITL CRYSTAL STRUCTURE OF MUTANT HUMAN MACROPHAGE CAPPING PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2w86 FBN1 crystal structure of fibrillin-1 domains cbegf9hyb2cbegf10, calcium saturated form 1.8Å AUTH S.A.JENSEN,S.IQBAL,E.D.LOWE,C.REDFIELD,P.A.HANDFORDTITL STRUCTURE AND INTERDOMAIN INTERACTIONS OF A HYBRIDTITL 2 DOMAIN: A DISULPHIDE-RICH MODULE OF THETITL 3 FIBRILLIN/LTBP SUPERFAMILY OF MATRIX PROTEINS.REF STRUCTURE V. 17 759 2009REFN ISSN 0969-2126PMID 19446531DOI 10.1016/J.STR.2009.03.014 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants