Assessment of Structural Intolerance and Durability
General Structure Information 2gl8 RXRG human retinoic acid receptor rxr-gamma ligand-binding domain 2.4Å AUTH A.SCHUETZ,J.R.MIN,P.LOPPNAU,J.WEIGELT,M.SUNDSTROM,AUTH 2 A.M.EDWARDS,C.H.ARROWSMITH,A.BOCHKAREV,A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN RETINOIC ACID RECEPTORTITL 2 RXR-GAMMA LIGAND-BINDING DOMAIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1n3l YARS crystal structure of a human aminoacyl-trna synthetase cytokine 1.18Å AUTH X.-L.YANG,R.J.SKENE,D.E.MCREE,P.SCHIMMELTITL CRYSTAL STRUCTURE OF A HUMAN AMINOACYL-TRNA SYNTHETASETITL 2 CYTOKINEREF PROC.NATL.ACAD.SCI.USA V. 99 15369 2002REFN ISSN 0027-8424PMID 12427973DOI 10.1073/PNAS.242611799 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3c7x MMP14 hemopexin-like domain of matrix metalloproteinase 14 1.7Å AUTH A.TOCHOWICZ,P.GOETTIG,R.EVANS,R.VISSE,Y.SHITOMI,R.PALMISANO,AUTH 2 N.ITO,K.RICHTER,K.MASKOS,D.FRANKE,D.SVERGUN,H.NAGASE,W.BODE,AUTH 3 Y.ITOHTITL THE DIMER INTERFACE OF THE MEMBRANE TYPE 1 MATRIXTITL 2 METALLOPROTEINASE HEMOPEXIN DOMAIN: CRYSTAL STRUCTURE ANDTITL 3 BIOLOGICAL FUNCTIONSREF J.BIOL.CHEM. V. 286 7587 2011REFN ISSN 0021-9258PMID 21193411DOI 10.1074/JBC.M110.178434 Variant Set Distributions Mapped Variants
General Structure Information 2a72 RGS7 structure of the regulator of g-protein signaling domain of rgs7 2.0Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2dm1 VAV2 solution structure of the second sh3 domain of human protein vav-2 -1.0Å AUTH H.ENDO,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND SH3 DOMAIN OFTITL 2 HUMAN PROTEIN VAV-2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1z29 SULT1A2 crystal structures of sult1a2 and sult1a1*3: implications in the bioactivation of n-hydroxy-2-acetylamino fluorine (oh-aaf) 2.4Å AUTH J.LU,H.LI,J.ZHANG,M.LI,M.Y.LIU,X.AN,M.C.LIU,W.CHANGTITL CRYSTAL STRUCTURES OF SULT1A2 AND SULT1A1 *3: INSIGHTS INTOTITL 2 THE SUBSTRATE INHIBITION AND THE ROLE OF TYR149 IN SULT1A2.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 396 429 2010REFN ISSN 0006-291XPMID 20417180DOI 10.1016/J.BBRC.2010.04.109 Variant Set Distributions Ripley’s […]
General Structure Information 2grc SMARCA4 1.5 a structure of bromodomain from human brg1 protein, a central atpase of swi/snf remodeling complex 1.5Å AUTH M.SINGH,G.M.POPOWICZ,M.KRAJEWSKI,T.A.HOLAKTITL STRUCTURAL RAMIFICATION FOR ACETYL-LYSINETITL 2 RECOGNITION BY THE BROMODOMAIN OF HUMAN BRG1TITL 3 PROTEIN, A CENTRAL ATPASE OF THE SWI/SNFTITL 4 REMODELING COMPLEX.REF CHEMBIOCHEM V. 8 1308 2007REFN ISSN 1439-4227PMID 17582821DOI […]
General Structure Information 3sxs BMX crystal structure of bmx non-receptor tyrosine kinase complexed with pp2 1.89Å AUTH J.MUCKELBAUER,J.S.SACK,N.AHMED,J.BURKE,C.Y.CHANG,M.GAO,AUTH 2 J.TINO,D.XIE,A.J.TEBBENTITL X-RAY CRYSTAL STRUCTURE OF BONE MARROW KINASE IN THE XTITL 2 CHROMOSOME: A TEC FAMILY KINASE.REF CHEM.BIOL.DRUG DES. V. 78 739 2011REFN ISSN 1747-0277PMID 21883956DOI 10.1111/J.1747-0285.2011.01230.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4h3b MAPK10 crystal structure of jnk3 in complex with sab peptide 2.08Å AUTH J.D.LAUGHLIN,J.C.NWACHUKWU,M.FIGUERA-LOSADA,L.CHERRY,AUTH 2 K.W.NETTLES,P.V.LOGRASSOTITL STRUCTURAL MECHANISMS OF ALLOSTERY AND AUTOINHIBITION IN JNKTITL 2 FAMILY KINASES.REF STRUCTURE V. 20 2174 2012REFN ISSN 0969-2126PMID 23142346DOI 10.1016/J.STR.2012.09.021 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4hab PLK1 crystal structure of plk1 polo-box domain in complex with pl-49 2.65Å AUTH R.N.MURUGAN,J.E.PARK,D.LIM,M.AHN,C.CHEONG,T.KWON,K.Y.NAM,AUTH 2 S.H.CHOI,B.Y.KIM,D.Y.YOON,M.B.YAFFE,D.Y.YU,K.S.LEE,J.K.BANGTITL DEVELOPMENT OF CYCLIC PEPTOMER INHIBITORS TARGETING THETITL 2 POLO-BOX DOMAIN OF POLO-LIKE KINASE 1.REF BIOORG.MED.CHEM. V. 21 2623 2013REFN ISSN 0968-0896PMID 23498919DOI 10.1016/J.BMC.2013.02.020 Variant Set Distributions Mapped Variants