Assessment of Structural Intolerance and Durability
General Structure Information 4en0 TNFSF14 crystal structure of light 2.59Å AUTH W.LIU,C.ZHAN,H.CHENG,P.R.KUMAR,J.B.BONANNO,S.G.NATHENSON,AUTH 2 S.C.ALMOTITL MECHANISTIC BASIS FOR FUNCTIONAL PROMISCUITY IN THE TNF ANDTITL 2 TNF RECEPTOR SUPERFAMILIES: STRUCTURE OF THE LIGHT:DCR3TITL 3 ASSEMBLY.REF STRUCTURE V. 22 1252 2014REFN ISSN 0969-2126PMID 25087510DOI 10.1016/J.STR.2014.06.013 Variant Set Distributions Mapped Variants
General Structure Information 1wyq SPTBN2 solution structure of the second ch domain of human spectrin beta chain, brain 2 -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND CH DOMAIN OFTITL 2 HUMAN SPECTRIN BETA CHAIN, BRAIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2e5n ELL2 solution structure of the ell_n2 domain of target of rna polymerase ii elongation factor ell2 -1.0Å AUTH W.DANG,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ELL_N2 DOMAIN OF TARGETTITL 2 OF RNA POLYMERASE II ELONGATION FACTOR ELL2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3b6u KIF3B crystal structure of the motor domain of human kinesin family member 3b in complex with adp 1.8Å AUTH H.ZHU,Y.SHEN,W.TEMPEL,R.LANDRY,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL MOTOR DOMAIN OF HUMAN KINESIN FAMILY MEMBER 3B INTITL 2 COMPLEX WITH ADP.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4hdo KRIT1 crystal structure of the binary complex of krit1 bound to the rap1 gtpase 1.67Å AUTH A.R.GINGRAS,W.PUZON-MCLAUGHLIN,M.H.GINSBERGTITL THE STRUCTURE OF THE TERNARY COMPLEX OF KREV INTERACTIONTITL 2 TRAPPED 1 (KRIT1) BOUND TO BOTH THE RAP1 GTPASE AND THETITL 3 HEART OF GLASS (HEG1) CYTOPLASMIC TAIL.REF J.BIOL.CHEM. V. 288 23639 2013REFN ISSN […]
General Structure Information 3tv0 DCTN6 structure of dynactin p27 subunit 2.15Å AUTH Z.S.DEREWENDA,U.DEREWENDA,A.KOWALSKA,M.ZHENGTITL DYNACTIN TARGETS POLO-LIKE KINASE 1 TO KINETOCHORESREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2cw9 TIMM44 crystal structure of human tim44 c-terminal domain 1.9Å AUTH N.HANDA,S.KISHISHITA,S.MORITA,R.AKASAKA,Z.JIN,AUTH 2 J.CHRZAS,L.CHEN,Z.J.LIU,B.C.WANG,S.SUGANO,A.TANAKA,AUTH 3 T.TERADA,M.SHIROUZU,S.YOKOYAMATITL STRUCTURE OF THE HUMAN TIM44 C-TERMINAL DOMAIN INTITL 2 COMPLEX WITH PENTAETHYLENE GLYCOL: LIGAND-BOUNDTITL 3 FORM.REF ACTA CRYSTALLOGR.,SECT.D V. 63 1225 2007REFN ISSN 0907-4449PMID 18084070DOI 10.1107/S0907444907051463 Variant Set Distributions Mapped Variants
General Structure Information 4kp5 CA12 crystal structure of catalytic domain of human carbonic anhydrase isozyme xii with 2-chloro-4-[(pyrimidin-2-ylsulfanyl) acetyl]benzenesulfonamide 1.45Å AUTH E.CAPKAUSKAITE,A.ZUBRIENE,A.SMIRNOV,J.TORRESAN,M.KISONAITE,AUTH 2 J.KAZOKAITE,J.GYLYTE,V.MICHAILOVIENE,V.JOGAITE,E.MANAKOVA,AUTH 3 S.GRAZULIS,S.TUMKEVICIUS,D.MATULISTITL BENZENESULFONAMIDES WITH PYRIMIDINE MOIETY AS INHIBITORS OFTITL 2 HUMAN CARBONIC ANHYDRASES I, II, VI, VII, XII, AND XIIIREF BIOORG.MED.CHEM. V. 21 6937 2013REFN ISSN 0968-0896PMID 24103428DOI 10.1016/J.BMC.2013.09.029 Variant Set […]
General Structure Information 3h11 CFLAR zymogen caspase-8:c-flipl protease domain complex 1.9Å AUTH J.W.YU,P.D.JEFFREY,Y.SHITITL MECHANISM OF PROCASPASE-8 ACTIVATION BY C-FLIPL.REF PROC.NATL.ACAD.SCI.USA V. 106 8169 2009REFN ISSN 0027-8424PMID 19416807DOI 10.1073/PNAS.0812453106 Variant Set Distributions Mapped Variants
General Structure Information 4a9c INPPL1 crystal structure of human ship2 in complex with biphenyl 2,3,4,5,6-pentakisphosphate 2.1Å AUTH S.J.MILLS,C.PERSSON,G.COZIER,M.P.THOMAS,L.TRESAUGUES,AUTH 2 C.ERNEUX,A.M.RILEY,P.NORDLUND,B.V.L.POTTERTITL A SYNTHETIC POLYPHOSPHOINOSITIDE HEADGROUP SURROGATE INTITL 2 COMPLEX WITH SHIP2 PROVIDES A RATIONALE FOR DRUG DISCOVERY.REF ACS CHEM.BIOL. V. 7 822 2012REFN ISSN 1554-8929PMID 22330088DOI 10.1021/CB200494D Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]